The Multiple Roles of PTEN in Tumor Suppression
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The most likely enzyme to generate Ins(1,4,5,6)P4 is PTEN, a well-known tumour suppressor gene that is active in the nucleus and plays a role in chromosome stability.
“The most likely enzyme is the well-known tumour suppressor gene PTEN42,43, which is known to be active in the nucleus and to play a role in chromosome stability (reviewed in44).”
From Structure of Hdac3 Bound to Co-Repressor and Inositol Tetraphosphate (2012) · cites this paper as [44]
The citation to this review is attached to the statement that PTEN is active in the nucleus and plays a role in chromosome stability. Our copy instead says that very little is known about PTEN’s subcellular localization (Abstract, page unavailable); searches for nuclear activity and chromosome stability found no passage addressing either point. The review does identify PTEN as a tumor suppressor, but that is not the part attributed to this citation. (LLM, conf=0.74)
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- Authors
- Di Cristofano, A., & Pandolfi, P. P.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Pandolfi, Pier Paolo
- ORCID
- Pandolfi, Pier Paolo
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2000-02
- Volume
- 100
- Issue
- 4
- Pages
- 387-390
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1973577899
- Cited by
- 1,182
- References
- 20
- Citations by year
- 2026: 4 · 2025: 14 · 2024: 14 · 2023: 19 · 2022: 19 · 2021: 24 · 2020: 53 · 2019: 46 · 2018: 40 · 2017: 39 · 2016: 34 · 2015: 49 · 2014: 44 · 2013: 44 · 2012: 47
- FWCI
- 28.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Keywords
- PTEN, tumor suppression, tumor suppressor, programmed cell death, apoptosis, cell cycle arrest, cell adhesion, cell migration, cell differentiation, phosphatase, cancer
- MeSH terms
- Animals, Cell Adhesion, Cell Cycle, Humans, Neoplasms, Phosphoric Monoester Hydrolases, Signal Transduction, Genes, Tumor Suppressor, Apoptosis, Germ-Line Mutation, Tumor Suppressor Proteins, PTEN Phosphohydrolase
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