The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Strategies for Targeting Protein–Protein Interactions With Synthetic Agents
Abstract
The development of small‐molecule modulators of protein–protein interactions is a formidable goal, albeit one that possesses significant potential for the discovery of novel therapeutics. Despite the daunting challenges, a variety of examples exists for the inhibition of two large protein partners with low‐molecular‐weight ligands. This review discusses the strategies for targeting protein–protein interactions and the state of the art in the rational design of molecules that mimic the structures and functions of their natural targets.
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Cited by
Inhibition of α-helix-mediated protein–protein interactions using designed molecules
Azzarito, V., Long, K., Murphy, N. S., & Wilson, A. J. (2013) · Nature Chemistry · doi:10.1038/nchem.1568 · Cited by 727
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Drugging Membrane Protein Interactions
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Self-citationTanada, M., Tamiya, M., Matsuo, A., Chiyoda, A., Takano, K., Ito, T., Irie, M., Kotake, T., Takeyama, R., Kawada, H., et al. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c03886 · Cited by 188
Protein–protein interactions as targets for small-molecule therapeutics in cancer
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Metadata
- Authors
- Yin, H., & Hamilton, A. D.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2005-06-23
- Volume
- 44
- Issue
- 27
- Pages
- 4130-4163
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2154382529
- Cited by
- 453
- References
- 18
- FWCI
- 11.06
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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