The DOI matches its Crossref record; 142 of the 142 references it cites were found in a registry or an index.
Drugging Membrane Protein Interactions
Open accessAbstract
The majority of therapeutics target membrane proteins, accessible on the surface of cells, to alter cellular signaling. Cells use membrane proteins to transduce signals into cells, transport ions and molecules, bind cells to a surface or substrate, and catalyze reactions. Newly devised technologies allow us to drug conventionally “undruggable” regions of membrane proteins, enabling modulation of protein–protein, protein–lipid, and protein–nucleic acid interactions. In this review, we survey the state of the art of high-throughput screening and rational design in drug discovery, and we evaluate the advances in biological understanding and technological capacity that will drive pharmacotherapy forward against unorthodox membrane protein targets.
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Cites
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How many drug targets are there?
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Cited by
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Metadata
- Authors
- Yin, H., & Flynn, A. D.
- Venue
- Annual Review of Biomedical Engineering
- Publisher
- Annual Reviews
- Published
- 2016-07-11
- Volume
- 18
- Issue
- 1
- Pages
- 51-76
- ISSN
- 1523-9829 (ISSN-L)
- 1545-4274
- OpenAlex
- W2244890058
- Cited by
- 339
- References
- 142
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- green
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