Towards a Fully Synthetic Carbohydrate‐Based Anticancer Vaccine: Synthesis and Immunological Evaluation of a Lipidated Glycopeptide Containing the Tumor‐Associated Tn Antigen
Abstract
A spoonful of sugar …︁ A carbohydrate-based fully synthetic vaccine 1, composed of a tumor-associated Tn antigen, a peptide T epitope, and a lipopeptide (see structure), shows potential as a candidate against cancer. Incorporation of the glycolipopeptide into liposomes gave a formulation that was able to elicit a T cell dependent antibody response in mice.
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Recent Development in Carbohydrate-Based Cancer Vaccines
Guo, Z., & Wang, Q. (2009) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2009.08.010 · Cited by 149 · see citing works
Mishra, N., Tiwari, V. K., & Schmidt, R. R. (2020) · Carbohydrates in Drug Discovery and Development · doi:10.1016/b978-0-12-816675-8.00001-4 · Cited by 17 · see citing works
- Authors
- Buskas, T., Ingale, S., & Boons, G.
- Affiliations
- University of Georgia (US)
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2005-09-14
- Volume
- 44
- Issue
- 37
- Pages
- 5985-5988
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2167991675
- Cited by
- 145
- References
- 0
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 1 · 2023: 5 · 2022: 5 · 2021: 7 · 2020: 7 · 2019: 1 · 2018: 6 · 2017: 7 · 2016: 6 · 2015: 4 · 2014: 7 · 2013: 9 · 2012: 11
- FWCI
- 6.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (R01CA088986)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- carbohydrate-based vaccines, Tn antigen, glycopeptides, lipopeptides, tumor-associated antigens, T cell epitopes, liposomes, T cell-dependent antibody response, cancer immunotherapy, synthetic vaccines
- MeSH terms
- Amino Acid Sequence, Carbohydrate Conformation, Carbohydrates, Drug Evaluation, Preclinical, Glycopeptides, Lipids, Molecular Sequence Data, Antigens, Tumor-Associated, Carbohydrate, Cancer Vaccines
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