Recent Development in Carbohydrate-Based Cancer Vaccines

Chemical Glycobiology

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The Immunogenicity of the Tumor‐Associated Antigen Lewisy May Be Suppressed by a Bifunctional Cross‐Linker Required for Coupling to a Carrier Protein

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Fully Synthetic Carbohydrate-Based Vaccines in Biochemically Relapsed Prostate Cancer: Clinical Trial Results With α-N-Acetylgalactosamine-O-Serine/Threonine Conjugate Vaccine

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Carbohydrate vaccines as immunotherapy for cancer

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Towards a Fully Synthetic Carbohydrate‐Based Anticancer Vaccine: Synthesis and Immunological Evaluation of a Lipidated Glycopeptide Containing the Tumor‐Associated Tn Antigen

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A Fully Synthetic Therapeutic Vaccine Candidate Targeting Carcinoma-Associated Tn Carbohydrate Antigen Induces Tumor-Specific Antibodies in Nonhuman Primates

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Vaccination with Theratope® (STn-KLH) as treatment for breast cancer

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New trends in carbohydrate-based vaccines

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Synthesis and Immunological Properties of N-Modified GM3 Antigens as Therapeutic Cancer Vaccines

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Thomsen-Friedenreich (TF) antigen as a target for prostate cancer vaccine: clinical trial results with TF cluster (c)-KLH plus QS21 conjugate vaccine in patients with biochemically relapsed prostate cancer

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Carbohydrate antigens as targets for active specific immunotherapy

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Anti-Tumor Immunity Provided by a Synthetic Multiple Antigenic Glycopeptide Displaying a Tri-Tn Glycotope

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Toward optimized carbohydrate-based anticancer vaccines: Epitope clustering, carrier structure, and adjuvant all influence antibody responses to Lewis y conjugates in mice

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Photodynamic therapy of vulvar intraepithelial neoplasia using 5-aminolevulinic acid

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Pursuit of Optimal Carbohydrate-Based Anticancer Vaccines: Preparation of a Multiantigenic Unimolecular Glycopeptide Containing the Tn, MBr1, and Lewisy Antigens

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Synthetic Vaccines Consisting of Tumor‐Associated MUC1 Glycopeptide Antigens and a T‐Cell Epitope for the Induction of a Highly Specific Humoral Immune Response

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Chemoselective Assembly and Immunological Evaluation of Multiepitopic Glycoconjugates Bearing Clustered Tn Antigen as Synthetic Anticancer Vaccines

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Comparison of antigen constructs and carrier molecules for augmenting the immunogenicity of the monosaccharide epithelial cancer antigen Tn

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Immunogenicity of synthetic TF-KLH (keyhole limpet hemocyanin) and sTn-KLH conjugates in colorectal carcinoma patients

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Consistent antibody response against ganglioside GD2 induced in patients with melanoma by a GD2 lactone-keyhole limpet hemocyanin conjugate vaccine plus immunological adjuvant QS-21.

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Towards a Self‐Adjuvanting Multivalent B and T cell Epitope Containing Synthetic Glycolipopeptide Cancer Vaccine

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Induction of antibodies against GM2 ganglioside by immunizing melanoma patients using GM2-keyhole limpet hemocyanin + QS21 vaccine: a dose-response study.

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Prospects for total synthesis: A vision for a totally synthetic vaccine targeting epithelial tumors

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Increasing the Antigenicity of Synthetic Tumor‐Associated Carbohydrate Antigens by Targeting Toll‐Like Receptors

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Experimental vaccine strategies for cancer immunotherapy

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Synthetic vaccines: synthesis of a dimeric Tn antigen-lipopeptide conjugate that elicits immune responses against Tn-expressing glycoproteins

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Immune sera and monoclonal antibodies define two configurations for the sialyl Tn tumor antigen.

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Biochemical Engineering of Surface α2–8 Polysialic Acid for Immunotargeting Tumor Cells

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Sialylation and malignant potential in tumour cell glycosylation mutants

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Antitumor activity of a self-adjuvanting glyco-lipopeptide vaccine bearing B cell, CD4+ and CD8+ T cell epitopes

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Efficient Metabolic Engineering of GM3 on Tumor Cells by N-Phenylacetyl- d -mannosamine

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Cancer vaccines: An update with special focus on ganglioside antigens (Review)

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Improving the Antigenicity of sTn Antigen by Modification of Its Sialic Acid Residue for Development of Glycoconjugate Cancer Vaccines

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Biologics through Chemistry: Total Synthesis of a Proposed Dual-Acting Vaccine Targeting Ovarian Cancer by Orchestration of Oligosaccharide and Polypeptide Domains

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Synthetic and Immunological Studies of 5′ - N -Phenylacetyl sTn to Develop Carbohydrate-Based Cancer Vaccines and to Explore the Impacts of Linkage between Carbohydrate Antigens and Carrier Proteins

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Bioengineering of Surface GD3 Ganglioside for Immunotargeting Human Melanoma Cells

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A preclinical study comparing approaches for augmenting the immunogenicity of a heptavalent KLH-conjugate vaccine against epithelial cancers

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Glycoconjugates in Cancer Therapy

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Comparison of antibody titers after immunization with monovalent or tetravalent KLH conjugate vaccines

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Efficient glycoengineering of GM3 on melanoma cell and monoclonal antibody-mediated selective killing of the glycoengineered cancer cell

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Synthetic Glycoconjugates as Human Vaccines

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Carbohydrate Antigens: Synthesis Aspects and Immunological Applications in Cancer

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Glycoconjugates facing the outside world

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The unfulfilled promise of melanoma vaccines.

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Synthetic Glycopeptide-Based Vaccines

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Short synthetic glycopeptides successfully induce antibody responses to carcinoma‐associated Tn antigen

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Induction of a Melanoma‐Specific Antibody Response by a Monovalent, but not a Divalent, Synthetic GM2 Neoglycopeptide

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Glycoconjugates As Vaccines for Cancer Immunotherapy: Clinical Trials and Future Directions

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GANAB and N-Glycans Substrates Are Relevant in Human Physiology, Polycystic Pathology and Multiple Sclerosis: A Review

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Recent trends and challenges on carbohydrate-based molecular scaffolding: general consideration toward impact of carbohydrates in drug discovery and development

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Deciphering the structure–immunogenicity relationship of anti- Candida glycoconjugate vaccines

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Supplementary Figure 1 from Exosome Targeting of Tumor Antigens Expressed by Cancer Vaccines Can Improve Antigen Immunogenicity and Therapeutic Efficacy

Rountree, R. B., Mandl, S. J., Nachtwey, J. M., et al. (2023) · doi:10.1158/0008-5472.22387743

Supplementary Figure 2 from Exosome Targeting of Tumor Antigens Expressed by Cancer Vaccines Can Improve Antigen Immunogenicity and Therapeutic Efficacy

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Dendritic cells-based cancer vaccine : Cancer immunotherapy with tumor/dendritic cell fusions

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