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Colorimetric Screening of DNA‐Binding Molecules with Gold Nanoparticle Probes
Abstract
Nanoparticle assemblies interconnected with DNA can be used to screen for DNA-binding molecules colorimetrically. The melting temperature of the nanoparticle assembly increases in the presence of strong-DNA-binding molecules. Thus, the strength of the DNA binding can be determined by the change in this sharp melting transition, which is observable by a blue-to-red color change (see picture).
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Citations
Cited by
Applications of Nanoparticles in Biology
De, M., Ghosh, P. S., & Rotello, V. M. (2008) · Advanced Materials · doi:10.1002/adma.200703183 · Cited by 1,547
Gold Nanomaterials at Work in Biomedicine
Yang, X., Yang, M., Pang, B., Vara, M., & Xia, Y. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00193 · Cited by 1,162
Mendes, B. B., Conniot, J., Avital, A., Yao, D., Jiang, X., Zhou, X., Sharf-Pauker, N., Xiao, Y., Adir, O., Liang, H., et al. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00104-y · Cited by 719
Nano-Flares: Probes for Transfection and mRNA Detection in Living Cells
Seferos, D. S., Giljohann, D. A., Hill, H. D., Prigodich, A. E., & Mirkin, C. A. (2007) · Journal of the American Chemical Society · doi:10.1021/ja0776529 · Cited by 710
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Metadata
- Authors
- Han, M. S., Lytton‐Jean, A. K. R., Oh, B., Heo, J., & Mirkin, C. A.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2006-03
- Volume
- 45
- Issue
- 11
- Pages
- 1807-1810
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2101818306
- Cited by
- 229
- References
- 0
- FWCI
- 10.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Han, M. S., Lytton‐Jean, A. K. R., Oh, B., Heo, J., & Mirkin, C. A. (2006). Colorimetric Screening of DNA‐Binding Molecules with Gold Nanoparticle Probes. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.200504277
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