The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Nano-Flares: Probes for Transfection and mRNA Detection in Living Cells
Open accessAbstract
We demonstrate that novel oligonucleotide-modified gold nanoparticle probes hybridized to fluorophore-labeled complements can be used as both transfection agents and cellular “nano-flares” for detecting mRNA in living cells. Nano-flares take advantage of the highly efficient fluorescence quenching properties of gold, cellular uptake of oligonucleotide nanoparticle conjugates without the use of transfection agents, and the enzymatic stability of such conjugates, thus overcoming many of the challenges to creating sensitive and effective intracellular probes. Nano-flares exhibit high signaling, have low background fluorescence, and are sensitive to changes in the number of RNA transcripts present in cells.
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Cites
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Self-citationMolecular Beacons: Probes that Fluoresce upon Hybridization
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Self-citationNanoparticle-Based Bio-Barcodes for the Ultrasensitive Detection of Proteins*
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Self-citationOligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation
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Self-citationVisualization of Single RNA Transcripts in Situ
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Cited by
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164
Programmable materials and the nature of the DNA bond
Jones, M. R., Seeman, N. C., & Mirkin, C. A. (2015) · Science · doi:10.1126/science.1260901 · Cited by 1,347
Self-citationColloidal Gold and Silver Triangular Nanoprisms
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Self-citationNanotechnology in cancer diagnosis: progress, challenges and opportunities
Zhang, Y., Li, M., Gao, X., Chen, Y., & Liu, T. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0833-3 · Cited by 510
Rational Engineering of a Dynamic, Entropy‐Driven DNA Nanomachine for Intracellular MicroRNA Imaging
Liang, C., Ma, P., Liu, H., Guo, X., Yin, B., & Ye, B. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201704147 · Cited by 389
Metadata
- Authors
- Seferos, D. S., Giljohann, D. A., Hill, H. D., Prigodich, A. E., & Mirkin, C. A.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-11-23
- Volume
- 129
- Issue
- 50
- Pages
- 15477-15479
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1977569722
- Cited by
- 710
- References
- 36
- FWCI
- 8.50
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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