Collagen‐Targeted MRI Contrast Agent for Molecular Imaging of Fibrosis
Abstract
A cyclic peptide specific for type I collagen is derivatized with three {Gd(dtpa)} moieties to create a molecular MRI contrast agent for fibrosis imaging. In a mouse model of myocardial infarction (heart attack), collagen levels are elevated in the infarct zone. MRI after injection of the contrast agent selectively enhances and delineates the infarct zone (see preinjection and postinjection images); dtpa=diethylenetriaminepentaacetate.
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Hybrid systems like PET/CT and PET/MRI integrate molecular and anatomical data, enhancing diagnostic precision.
“Hybrid systems like PET/CT and PET/MRI integrate molecular and anatomical data, enhancing diagnostic precision”
From Biomarker-Guided Imaging and AI-Augmented Diagnosis of Degenerative Joint Disease (2025) · cites this paper as [169]
Emerging technologies like photoacoustic imaging and multiparametric MRI further expand capabilities.
“while emerging technologies like photoacoustic imaging and multiparametric MRI further expand capabilities [169,170].”
From Biomarker-Guided Imaging and AI-Augmented Diagnosis of Degenerative Joint Disease (2025) · cites this paper as [169]
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Carlier, P. G., Marty, B., Scheidegger, O., Loureiro de Sousa, P., Baudin, P.-Y., Snezhko, E., & Vlodavets, D. (2016) · Journal of Neuromuscular Diseases · doi:10.3233/jnd-160145 · Cited by 186 · see citing works
Leuschner, F., & Nahrendorf, M. (2011) · Circulation Research · doi:10.1161/circresaha.110.232678 · Cited by 110 · see citing works
Small animal cardiovascular MR imaging and spectroscopy
Bakermans, A. J., Abdurrachim, D., Moonen, R. P. M., Motaal, A. G., Prompers, J. J., Strijkers, G. J., Vandoorne, K., & Nicolay, K. (2015) · Progress in Nuclear Magnetic Resonance Spectroscopy · doi:10.1016/j.pnmrs.2015.03.001 · Cited by 35 · see citing works
Collagen-targeted molecular imaging in diffuse liver diseases
Zhou, I. Y., Tanabe, K. K., Fuchs, B. C., & Caravan, P. (2020) · Abdominal Radiology · doi:10.1007/s00261-020-02677-2 · Cited by 14 · see citing works
Self-citationBiomarker-Guided Imaging and AI-Augmented Diagnosis of Degenerative Joint Disease
Kumar, R., Sporn, K., Borole, A., Khanna, A., Gowda, C., Paladugu, P., Ngo, A., Jagadeesan, R., Zaman, N., & Tavakkoli, A. (2025) · Diagnostics · doi:10.3390/diagnostics15111418 · Cited by 10 · see citing works
“Hybrid systems like PET/CT and PET/MRI integrate molecular and anatomical data, enhancing diagnostic precision, while emerging technologies like photoacoustic imaging and multiparametric MRI further expand capabilities [169,170].”
- Authors
- Caravan, P., Das, B., Dumas, S., Epstein, F. H., Helm, P. A., Jacques, V., Koerner, S., Kolodziej, A., Shen, L., Sun, W., & Zhang, Z.
- Affiliations
- Massachusetts General Hospital (US)
- Epix Pharmaceuticals (United States) (US)
- University of Virginia (US)
- Corresponding author
- Caravan, Peter
- ORCID
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2007-10-26
- Volume
- 46
- Issue
- 43
- Pages
- 8171-8173
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2167991331
- Cited by
- 268
- References
- 0
- Citations by year
- 2026: 8 · 2025: 20 · 2024: 16 · 2023: 9 · 2022: 13 · 2021: 11 · 2020: 21 · 2019: 20 · 2018: 13 · 2017: 18 · 2016: 15 · 2015: 18 · 2014: 4 · 2013: 19 · 2012: 15
- FWCI
- 6.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Lanthanide and Transition Metal Complexes
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- type I collagen, cyclic peptides, gadolinium-based contrast agents, MRI contrast agents, fibrosis imaging, myocardial infarction, molecular imaging, diethylenetriaminepentaacetate
- MeSH terms
- Animals, Collagen, Contrast Media, Fibrosis, Humans, Magnetic Resonance Imaging, Mice
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