Collagen-targeted molecular imaging in diffuse liver diseases
Open accessAbstract
Liver fibrosis is a common pathway shared by all progressive chronic liver diseases (CLD) regardless of the underlying etiologies. With liver biopsy being the gold standard in assessing fibrosis degree, there is a large unmet clinical need to develop non-invasive imaging tools that can directly and repeatedly quantify fibrosis throughout the liver for a more accurate assessment of disease burden, progression, and treatment response. Type I collagen is a particularly attractive target for molecular imaging as its excessive deposition is specific to fibrosis, and it is present in concentrations suitable for many imaging modalities. Novel molecular MRI contrast agents designed to bind with collagen provide direct quantification of collagen deposition, which have been validated across animal species and liver injury models. Collagen-targeted molecular imaging probes hold great promise not only as a tool for initial staging and surveillance of fibrosis progression, but also as a marker of fibrosis regression in drug trials.
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MRI contrast agents or probes that quantify ECM components in liver show promise.
“Most recently, imaging tests using magnetic resonance imaging (MRI) contrast agents or probes that quantify components of extracellular matrix in liver show promise (301, 302).”
From Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH) (2023) · cites this paper as [302]
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- Authors
- Zhou, I. Y., Tanabe, K. K., Fuchs, B. C., & Caravan, P.
- Affiliations
- Harvard University (US)
- Ferring Research Institute (United States) (US)
- Corresponding author
- Caravan, Peter
- Venue
- Abdominal Radiology
- Published
- 2020-07-31
- Volume
- 45
- Issue
- 11
- Pages
- 3545-3556
- ISSN
- 2366-004X (ISSN-L)
- 2366-0058
- PMC
- PMC7606709
- OpenAlex
- W3046557702
- Cited by
- 14
- References
- 70
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 2
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Abdominal Radiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK104956, DK104302, DK121789)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- liver fibrosis, type I collagen, chronic liver disease, fibrosis regression, liver injury model
- MeSH terms
- Animals, Collagen, Liver, Liver Cirrhosis, Liver Diseases, Molecular Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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