Cited by 110Cardiac Imaging and DiagnosticsMedical Imaging Techniques and ApplicationsAtherosclerosis and Cardiovascular Diseases

Molecular Imaging of Coronary Atherosclerosis and Myocardial Infarction: Considerations for the Bench and Perspectives for the Clinic

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Leuschner, Florian, Nahrendorf, Matthias·2011·Circulation Research

Abstract

Motivated by the promise to transform preclinical research and clinical care, cardiovascular molecular imaging has made advances toward targeting coronary atherosclerosis and heart failure. Here, we discuss recent progress in the field, highlight how molecular imaging may facilitate preventive patient care, and review specific challenges associated with coronary and heart failure imaging. Practical considerations stress the potential of fluorescence imaging for basic research and discuss hybrid protocols such as FMT-CT and PET-MRI.

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Crossref · 10.1161/circresaha.110.232678

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  • MRI and CT were initially considered to lack sufficient sensitivity for molecular imaging agents, but with new nanoparticulate agents they are increasingly explored for this purpose.

    “For molecular imaging purposes both techniques were initially considered to lack sufficient sensitivity for the detection of exogenously administered molecular imaging agents, but with the rise of new and potent nanoparticulate agents MRI and CT are increasingly being explored for this purpose119.”

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Authors
Leuschner, F., & Nahrendorf, M.
Affiliations
Harvard University (US)
Venue
Circulation Research
Published
2011-03-04
Volume
108
Issue
5
Pages
593-606
ISSN
  • 0009-7330 (ISSN-L)
  • 1524-4571
OpenAlex
W2061136178
Cited by
110
References
119
Citations by year
2026: 2 · 2025: 3 · 2024: 5 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 6 · 2016: 9 · 2015: 12 · 2014: 17 · 2013: 16 · 2012: 21
FWCI
2.95
Type
journal article
Language
en
Open access
Locations
  • Circulation Research (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Circulation Research
Funders
  • American Heart Association
  • Deutsche Herzstiftung
  • National Heart, Lung, and Blood Institute (HHSN268201000044C, R01HL095629, R01HL096576)
  • National Institute of Biomedical Imaging and Bioengineering (R01EB006432)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords
coronary artery disease, myocardial infarction, fluorescence imaging, PET/MR imaging, atherosclerosis imaging, preventive cardiology
MeSH terms
Coronary Artery Disease, Humans, Magnetic Resonance Imaging, Myocardial Infarction, Tomography, X-Ray Computed, Positron-Emission Tomography, Molecular Imaging

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