Molecular Imaging of Coronary Atherosclerosis and Myocardial Infarction: Considerations for the Bench and Perspectives for the Clinic
Open accessAbstract
Motivated by the promise to transform preclinical research and clinical care, cardiovascular molecular imaging has made advances toward targeting coronary atherosclerosis and heart failure. Here, we discuss recent progress in the field, highlight how molecular imaging may facilitate preventive patient care, and review specific challenges associated with coronary and heart failure imaging. Practical considerations stress the potential of fluorescence imaging for basic research and discuss hybrid protocols such as FMT-CT and PET-MRI.
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MRI and CT were initially considered to lack sufficient sensitivity for molecular imaging agents, but with new nanoparticulate agents they are increasingly explored for this purpose.
“For molecular imaging purposes both techniques were initially considered to lack sufficient sensitivity for the detection of exogenously administered molecular imaging agents, but with the rise of new and potent nanoparticulate agents MRI and CT are increasingly being explored for this purpose119.”
From Perspectives and opportunities for nanomedicine in the management of atherosclerosis (2011) · cites this paper as [119]
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- Authors
- Leuschner, F., & Nahrendorf, M.
- Affiliations
- Harvard University (US)
- Venue
- Circulation Research
- Published
- 2011-03-04
- Volume
- 108
- Issue
- 5
- Pages
- 593-606
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC3397211
- OpenAlex
- W2061136178
- Cited by
- 110
- References
- 119
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 6 · 2016: 9 · 2015: 12 · 2014: 17 · 2013: 16 · 2012: 21
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Circulation Research
- Funders
- American Heart Association
- Deutsche Herzstiftung
- National Heart, Lung, and Blood Institute (HHSN268201000044C, R01HL095629, R01HL096576)
- National Institute of Biomedical Imaging and Bioengineering (R01EB006432)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- coronary artery disease, myocardial infarction, fluorescence imaging, PET/MR imaging, atherosclerosis imaging, preventive cardiology
- MeSH terms
- Coronary Artery Disease, Humans, Magnetic Resonance Imaging, Myocardial Infarction, Tomography, X-Ray Computed, Positron-Emission Tomography, Molecular Imaging
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