The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Molecular Mechanism of Inhibition of the Human Protein Complex Hsp90–Cdc37, a Kinome Chaperone–Cochaperone, by Triterpene Celastrol
Abstract
The correct target: The cell division cycle protein 37 (Cdc37) and the heat shock protein (Hsp90) are molecular chaperones crucial for the folding and stabilization of protein kinases including the oncogenic kinases. NMR studies show that celastrol, a recently identified triterpene targeting Hsp90, in fact binds to Cdc37 and disrupts the Cdc37–Hsp90 complex. Celastrol inactivates Cdc37 through a thiol-mediated mechanism.
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Citations
Cites
Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer
Liby, K. T., Yore, M. M., & Sporn, M. B. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2129 · Cited by 637
Cited by
Celastrol-loaded PEG- b -PPS nanocarriers as an anti-inflammatory treatment for atherosclerosis
Allen, S. D., Liu, Y.-G., Kim, T., Bobbala, S., Yi, S., Zhang, X., Choi, J., & Scott, E. A. (2019) · Biomaterials Science · doi:10.1039/c8bm01224e · Cited by 95
Chadli, A., Felts, S. J., Wang, Q., Sullivan, W. P., Botuyan, M. V., Fauq, A., Ramirez-Alvarado, M., & Mer, G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.081018 · Cited by 94
Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids
Wang, H., Teriete, P., Hu, A., Raveendra-Panickar, D., Pendelton, K., Lazo, J. S., Eiseman, J., Holien, T., Misund, K., Oliynyk, G., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6116 · Cited by 53
Metadata
- Authors
- Sreeramulu, S., Gande, S. L., Göbel, M., & Schwalbe, H.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2009-07-22
- Volume
- 48
- Issue
- 32
- Pages
- 5853-5855
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2148065722
- Cited by
- 178
- References
- 1
- FWCI
- 5.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sreeramulu, S., Gande, S. L., Göbel, M., & Schwalbe, H. (2009). Molecular Mechanism of Inhibition of the Human Protein Complex Hsp90–Cdc37, a Kinome Chaperone–Cochaperone, by Triterpene Celastrol. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.200900929
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