Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer

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Coregulator Function: A Key to Understanding Tissue Specificity of Selective Receptor Modulators

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IKK/NF- B signaling: balancing life and death - a new approach to cancer therapy

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Nrf2–Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species

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The tumour microenvironment as a target for chemoprevention

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PPAR and human metabolic disease

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Linked: How Everything Is Connected to Everything Else and What It Means

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High-Throughput Mapping of a Dynamic Signaling Network in Mammalian Cells

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Pharmacological activities of natural triterpenoids and their therapeutic implications

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A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR

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Yersinia YopJ Acetylates and Inhibits Kinase Activation by Blocking Phosphorylation

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Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists

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Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

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Celastrol, a Triterpene Extracted from the Chinese “Thunder of God Vine,” Is a Potent Proteasome Inhibitor and Suppresses Human Prostate Cancer Growth in Nude Mice

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Disruption of <i>Nrf2</i> enhances susceptibility to severe airway inflammation and asthma in mice

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Extremely potent triterpenoid inducers of the phase 2 response: Correlations of protection against oxidant and inflammatory stress

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Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid.

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A Systems Model of Signaling Identifies a Molecular Basis Set for Cytokine-Induced Apoptosis

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Nrf2, a multi‐organ protector?

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Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity.

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Apoptosis-targeted therapies for cancer

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Apoptosis as a Novel Target for Cancer Chemoprevention

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Inducible Nitric Oxide Synthase Binds, S-Nitrosylates, and Activates Cyclooxygenase-2

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The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress

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Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

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Redox-Dependent Transcriptional Regulation

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Biosynthetic diversity in plant triterpene cyclization

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Stat3 regulates genes common to both wound healing and cancer

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Retinoid X Receptor Heterodimers in the Metabolic Syndrome

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Chemoprevention: an essential approach to controlling cancer

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Synthesis and Structure-Activity Relationships of Novel Retinoid X Receptor-Selective Retinoids

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Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide

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Design and Synthesis of Potent Retinoid X Receptor Selective Ligands That Induce Apoptosis in Leukemia Cells

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Retinoids Selective for Retinoid X Receptor Response Pathways

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Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages.

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An Inducible Pathway for Degradation of FLIP Protein Sensitizes Tumor Cells to TRAIL-induced Apoptosis

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Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis

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The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling

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A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity.

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Inflammation and therapeutic vaccination in CNS diseases

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Synthetic oleanane and ursane triterpenoids with modified rings A and C: a series of highly active inhibitors of nitric oxide production in mouse macrophages

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Triterpenoid CDDO-Me Blocks the NF-κB Pathway by Direct Inhibition of IKKβ on Cys-179

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Radical medicine: treating ageing to cure disease

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Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor–β1

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Design and synthesis of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages

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Nrf2 as a target for cancer chemoprevention

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Potent Protection against Aflatoxin-Induced Tumorigenesis through Induction of Nrf2-Regulated Pathways by the Triterpenoid 1-[2-Cyano-3-,12-Dioxooleana-1,9(11)-Dien-28-Oyl]Imidazole

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Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia

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In vivo modulation of the Parkinsonian phenotype by Nrf2

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The triterpenoid CDDO induces apoptosis in refractory CLL B cells

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Activity loss and the onset of depressive symptoms: Do some activities matter more than others?

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Inhibition of the tumor-promoting action of 12-O-tetradecanoylphorbol-13-acetate by some oleanane-type triterpenoid compounds.

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A Synthetic Triterpenoid, 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic Acid (CDDO), Is a Ligand for the Peroxisome Proliferator-Activated Receptor γ

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c-Jun NH2-Terminal Kinase-Mediated Up-regulation of Death Receptor 5 Contributes to Induction of Apoptosis by the Novel Synthetic Triterpenoid Methyl-2-Cyano-3,12-Dioxooleana-1, 9-Dien-28-Oate in Human Lung Cancer Cells

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Mast cells in autoimmune disease

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The retinoid X receptor-selective retinoid, LGD1069, prevents the development of estrogen receptor-negative mammary tumors in transgenic mice.

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Cancer chemoprevention: scientific promise, clinical uncertainty

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Beyond tamoxifen: the retinoid X receptor-selective ligand LGD1069 (TARGRETIN) causes complete regression of mammary carcinoma.

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Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), inhibit activation of nuclear factor-κB by inhibiting both its nuclear localization and ability to bind DNA

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A Synthetic Triterpenoid, CDDO-Me, Inhibits IκBα Kinase and Enhances Apoptosis Induced by TNF and Chemotherapeutic Agents through Down-Regulation of Expression of Nuclear Factor κB–Regulated Gene Products in Human Leukemic Cells

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The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo.

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15-Deoxy-Δ12,14-prostaglandin J2 as a potential endogenous regulator of redox-sensitive transcription factors

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Activation of peroxisome proliferator-activated receptor gamma by a novel synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest and apoptosis in breast cancer cells.

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A novel dicyanotriterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile, active at picomolar concentrations for inhibition of nitric oxide production

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Suppression of mammary tumorigenesis in transgenic mice by the RXR-selective retinoid, LGD1069.

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The Synthetic Triterpenoids CDDO-Methyl Ester and CDDO-Ethyl Amide Prevent Lung Cancer Induced by Vinyl Carbamate in A/J Mice

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The novel triterpenoid CDDO induces apoptosis and differentiation of human osteosarcoma cells by a caspase-8 dependent mechanism

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The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti–multiple myeloma (MM) activity and overcome bortezomib resistance

Chauhan, D., Li, G., Podar, K., Hideshima, T., Shringarpure, R., Catley, L. P., Mitsiades, C. S., Munshi, N. C., Tai, Y., Suh, N., et al. (2003) · Blood · doi:10.1182/blood-2003-08-2873 · Cited by 131 · see citing works

Synthetic Triterpenoids Cooperate with Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand to Induce Apoptosis of Breast Cancer Cells

Hyer, M. L., Croxton, R., Krajewska, M., Krajewski, S., Kress, C. L., Lü, M., Suh, N., Sporn, M. B., Cryns, V. L., Zapata, J. M., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3319 · Cited by 128 · see citing works

The novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid induces apoptosis of human myeloid leukemia cells by a caspase-8-dependent mechanism.

Ito, Y., Pandey, P., Place, A., Sporn, M. B., Gribble, G. W., Honda, T., Kharbanda, S. M., & Kufe, D. W. (2000) · PubMed · Cited by 126 · see citing works

Multi-Institutional Phase I/II Trial of Oral Bexarotene in Combination With Cisplatin and Vinorelbine in Previously Untreated Patients With Advanced Non–Small-Cell Lung Cancer

Khuri, F. R., Rigas, J. R., Figlin, R. A., Gralla, R. J., Shin, D. M., Munden, R. F., Fox, N., Huyghe, M. R., Kean, Y., Reich, S. D., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.10.2626 · Cited by 121 · see citing works

Olive Fruit Extracts Inhibit Proliferation and Induce Apoptosis in HT-29 Human Colon Cancer Cells

Juan, M. E., Wenzel, U., Ruíz-Gutiérrez, V., Daniel, H., & Planas, J. M. (2006) · Journal of Nutrition · doi:10.1093/jn/136.10.2553 · Cited by 119 · see citing works

The Synthetic Triterpenoid CDDO-Imidazolide Suppresses STAT Phosphorylation and Induces Apoptosis in Myeloma and Lung Cancer Cells

Liby, K. T., Voong, N., Williams, C. R., Risingsong, R., Royce, D. B., Honda, T., Gribble, G. W., Sporn, M. B., & Letterio, J. J. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0215 · Cited by 118 · see citing works

Novel Synthetic Oleanane and Ursane Triterpenoids with Various Enone Functionalities in Ring A as Inhibitors of Nitric Oxide Production in Mouse Macrophages

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Multicenter Phase II Study of Oral Bexarotene for Patients With Metastatic Breast Cancer

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Rexinoid-Triggered Differentiation and Tumor-Selective Apoptosis of Acute Myeloid Leukemia by Protein Kinase A–Mediated Desubordination of Retinoid X Receptor

Altucci, L., Rossin, A., Hirsch, O., Nebbioso, A., Vitoux, D., Wilhelm, E., Guidez, F., Simone, M. D., Schiavone, E. M., Grimwade, D. J., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3569 · Cited by 113 · see citing works

Transcriptional regulation via cysteine thiol modification: A novel molecular strategy for chemoprevention and cytoprotection

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The novel triterpenoid CDDO and its derivatives induce apoptosis by disruption of intracellular redox balance.

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The synthetic triterpenoid 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole blocks nuclear factor-κB activation through direct inhibition of IκB kinase β

Yore, M. M., Liby, K. T., Honda, T., Gribble, G. W., & Sporn, M. B. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0444 · Cited by 109 · see citing works

Studies on the reactivity of CDDO, a promising new chemopreventive and chemotherapeutic agent: implications for a molecular mechanism of action

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2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) Directly Targets Mitochondrial Glutathione to Induce Apoptosis in Pancreatic Cancer

Samudio, I. J., Konopleva, M. Y., Hail, N., Shi, Y.-X., McQueen, T. J., Hsu, T., Evans, R. L., Honda, T., Gribble, G. W., Sporn, M. B., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507518200 · Cited by 102 · see citing works

Human Immunodeficiency Virus Type 1-Induced Macrophage Gene Expression Includes the p21 Gene, a Target for Viral Regulation

Vázquez, N., Greenwell‐Wild, T., Marinos, N. J., Swaim, W. D., Nares, S., Ott, D. E., Schubert, U., Henklein, P., Orenstein, J. M., Sporn, M. B., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.7.4479-4491.2005 · Cited by 102 · see citing works

A retinoid X receptor (RXR)-selective retinoid reveals that RXR-α is potentially a therapeutic target in breast cancer cell lines, and that it potentiates antiproliferative and apoptotic responses to peroxisome proliferator-activated receptor ligands

Crowe, D. L., & Chandraratna, R. A. S. (2004) · Breast Cancer Research · doi:10.1186/bcr913 · Cited by 101 · see citing works

The Novel Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) Potently Enhances Apoptosis Induced by Tumor Necrosis Factor in Human Leukemia Cells

Stadheim, T. A., Suh, N., Ganju, N., Sporn, M. B., & Eastman, A. R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108974200 · Cited by 91 · see citing works

Synthetic triterpenoids enhance transforming growth factor beta/Smad signaling.

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Synthetic triterpenoids activate a pathway for apoptosis in AML cells involving downregulation of FLIP and sensitization to TRAIL

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BRCA1 Transcriptionally Regulates Damaged DNA Binding Protein (DDB2) In the DNA Repair Response Following UV-Irradiation

Takimoto, R., MacLachlan, T. K., Dicker, D. T., Niitsu, Y., Mori, T., & El‐Deiry, W. S. (2002) · Cancer Biology & Therapy · doi:10.4161/cbt.65 · Cited by 84 · see citing works

2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid and Related Compounds Inhibit Growth of Colon Cancer Cells through Peroxisome Proliferator-Activated Receptor γ-Dependent and -Independent Pathways

Chintharlapalli, S. R., Papineni, S., Konopleva, M. Y., Andreef, M., Samudio, I. J., & Safe, S. H. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.011437 · Cited by 83 · see citing works

Induction of redox imbalance and apoptosis in multiple myeloma cells by the novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid

Ikeda, T., Nakata, Y., Kimura, F., Sato, K., Anderson, K. C., Motoyoshi, K., Sporn, M. B., & Kufe, D. W. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.39.3.1 · Cited by 81 · see citing works

Enantioselective Syntheses of Potent Retinoid X Receptor Ligands: Differential Biological Activities of Individual Antipodes

Vuligonda, V., Thacher, S. M., & Chandraratna, R. A. S. (2001) · Journal of Medicinal Chemistry · doi:10.1021/jm0100584 · Cited by 79 · see citing works

TGF-β signaling in T cells: roles in lymphoid and epithelial neoplasia

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The Rexinoid LG100754 Is a Novel RXR:PPARγ Agonist and Decreases Glucose Levelsin Vivo

Cesario, R. M., Klausing, K., Razzaghi, H., Crombie, D. L., Rungta, D. K., Heyman, R. A., & Lala, D. S. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.8.0677 · Cited by 71 · see citing works

Biological Characterization of a Heterodimer-Selective Retinoid X Receptor Modulator: Potential Benefits for the Treatment of Type 2 Diabetes

Leibowitz, M. D., Ardecky, R., Boehm, M. F., Broderick, C. L., Carfagna, M. A., Crombie, D. L., D’Arrigo, J., Etgen, G. J., Faul, M. M., Grese, T. A., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0690 · Cited by 71 · see citing works

Identification of a novel synthetic triterpenoid, methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate, that potently induces caspase-mediated apoptosis in human lung cancer cells.

Kim, K. B., Lotan, R., Yue, P., Sporn, M. B., Suh, N., Gribble, G. W., Honda, T., Wu, G. S., Hong, W. K., & Sun, S. Y. (2002) · PubMed · Cited by 70 · see citing works

Synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest in HER2-overexpressing breast cancer cells

Konopleva, M. Y., Zhang, W., Shi, Y.-X., McQueen, T. J., Tsao, T., Abdelrahim, M., Munsell, M. F., Johansen, M. J., Yu, D., Madden, T. L., et al. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0350 · Cited by 70 · see citing works

Effect of the Retinoid X Receptor-Selective Ligand LGD1069 on Mammary Carcinoma After Tamoxifen Failure

Bischoff, E. D., Heyman, R. A., & Lamph, W. W. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.24.2118 · Cited by 66 · see citing works

Prevention and treatment of experimental breast cancer with the combination of a new selective estrogen receptor modulator, arzoxifene, and a new rexinoid, LG 100268.

Suh, N., Lamph, W. W., Glasebrook, A. L., Grese, T. A., Palkowitz, A. D., Williams, C. R., Risingsong, R., Farris, M. R., Heyman, R. A., & Sporn, M. B. (2002) · PubMed · Cited by 65 · see citing works

The novel triterpenoid CDDO-Me suppresses MAPK pathways and promotes p38 activation in acute myeloid leukemia cells

Konopleva, M. Y., Contractor, R., Kurinna, S. M., Chen, W., Andreeff, M., & Ruvolo, P. P. (2005) · Leukemia · doi:10.1038/sj.leu.2403828 · Cited by 65 · see citing works

Effects of Rexinoids on Thyrotrope Function and the Hypothalamic-Pituitary-Thyroid Axis

Sharma, V., Hays, W. R., Wood, W. M., Pugazhenthi, U., Germain, D. L. S., Bianco, A. C., Krężel, W., Chambon, P., & Haugen, B. R. (2005) · Endocrinology · doi:10.1210/en.2005-0706 · Cited by 64 · see citing works

The Retinoid X Receptor-Selective Retinoid, LGD1069, Down-regulates Cyclooxygenase-2 Expression in Human Breast Cells through Transcription Factor Crosstalk: Implications for Molecular-Based Chemoprevention

Kong, G., Kim, H.-T., Wu, K., DeNardo, D. G., Hilsenbeck, S. G., Xu, X.-C., Lamph, W. W., Bissonnette, R. P., Dannenberg, A. J., & Brown, P. H. (2005) · Cancer Research · doi:10.1158/0008-5472.can-03-2912 · Cited by 63 · see citing works

Specific Chemopreventive Agents Trigger Proteasomal Degradation of G1 Cyclins: Implications for Combination Therapy

Dragnev, K. H., Pitha, I., Ma, Y., Petty, W. J., Sekula, D., O’Sullivan-Murphy, B., Rendi, M. H., Suh, N., Desai, N. B., Sporn, M. B., et al. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0271 · Cited by 62 · see citing works

The Combination of the Rexinoid, LG100268, and a Selective Estrogen Receptor Modulator, Either Arzoxifene or Acolbifene, Synergizes in the Prevention and Treatment of Mammary Tumors in an Estrogen Receptor–Negative Model of Breast Cancer

Liby, K. T., Rendi, M. H., Suh, N., Royce, D. B., Risingsong, R., Williams, C. R., Lamph, W. W., Labrie, F., Krajewski, S., Xu, X., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1119 · Cited by 60 · see citing works

The Selective Estrogen Receptor Modulator Arzoxifene and the Rexinoid LG100268 Cooperate to Promote Transforming Growth Factor β-Dependent Apoptosis in Breast Cancer

Rendi, M. H., Suh, N., Lamph, W. W., Krajewski, S., Reed, J. C., Heyman, R. A., Berchuck, A., Liby, K. T., Risingsong, R., Royce, D. B., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0234 · Cited by 60 · see citing works

Bexarotene and Erlotinib for Aerodigestive Tract Cancer

Dragnev, K. H., Petty, W. J., Shah, S. J., Biddle, A., Desai, N. B., Memoli, V. A., Rigas, J. R., & Dmitrovsky, E. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.01.9521 · Cited by 59 · see citing works

A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate: direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis

Samudio, I., Konopleva, M., Pelicano, H., Huang, P., Frolova, O., Bornmann, W., Ying, Y., Evans, R., Contractor, R., & Andreeff, M. (2006) · Molecular Pharmacology · doi:10.1124/mol.105.018051 · Cited by 58 · see citing works

Design, Synthesis, and Biological Evaluation of Biotin Conjugates of 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic Acid for the Isolation of the Protein Targets

Honda, T., Janosik, T., Honda, Y., Han, J., Liby, K. T., Williams, C. R., Couch, R. D., Anderson, A. C., Sporn, M. B., & Gribble, G. W. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm049727e · Cited by 56 · see citing works

CDDO induces apoptosis via the intrinsic pathway in lymphoid cells

Inoue, S., Snowden, R. T., Dyer, M. J. S., & Cohen, G. M. (2004) · Leukemia · doi:10.1038/sj.leu.2403328 · Cited by 56 · see citing works

A selective retinoid X receptor agonist bexarotene (LGD1069, targretin) inhibits angiogenesis and metastasis in solid tumours

Yen, W.-C., Prudente, R. Y., Corpuz, M., Negro-Vilar, A. F., & Lamph, W. W. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6602995 · Cited by 56 · see citing works

Novel (2E,4E,6Z)-7-(2-Alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic Acid Retinoid X Receptor Modulators Are Active in Models of Type 2 Diabetes

Michellys, P., Ardecky, R., Chen, J. H., Crombie, D. L., Etgen, G. J., Faulkner, A. L., Faul, M. M., Grese, T. A., Heyman, R. A., Karanewsky, D. S., et al. (2003) · Journal of Medicinal Chemistry · doi:10.1021/jm020340q · Cited by 52 · see citing works

Evidence Supporting a Role for Calcium in Apoptosis Induction by the Synthetic Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic Acid (CDDO)

Hail, N., Konopleva, M. Y., Sporn, M. B., Lotan, R., & Andreeff, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312758200 · Cited by 51 · see citing works

Generation of mutator mutants during carcinogenesis

Venkatesan, R. N., Bielas, J. H., & Loeb, L. A. (2005) · DNA repair · doi:10.1016/j.dnarep.2005.10.012 · Cited by 49 · see citing works

Depletion of ntracellular Glutathione Contributes to JNK-Mediated Death Receptor 5 Upregulation and Apoptosis Induction by the Novel Synthetic Triterpenoid Methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me)1

Yue, P., Zhou, Z., Khuri, F. R., & Sun, S. (2006) · Cancer Biology & Therapy · doi:10.4161/cbt.5.5.2565 · Cited by 49 · see citing works

Structure-Based Design of Potent Retinoid X Receptor α Agonists

Haffner, C. D., Lenhard, J. M., Miller, A. B., McDougald, D. L., Dwornik, K. A., Ittoop, O. R. R., Robert T. Gampe, Xu, H. E., Blanchard, S., Montana, V. G., et al. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm030565g · Cited by 49 · see citing works

Growth-inhibitory effect of a novel synthetic triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, on ovarian carcinoma cell lines not dependent on peroxisome proliferator-activated receptor-γ expression

Melichar, B., Konopleva, M. Y., Hu, W., Melicharová, K., Andreeff, M., & Freedman, R. S. (2004) · Gynecologic Oncology · doi:10.1016/j.ygyno.2004.01.008 · Cited by 48 · see citing works

Design, synthesis, and anti-inflammatory activity both in vitro and in vivo of new betulinic acid analogues having an enone functionality in ring A

Honda, T., Liby, K. T., Su, X., Sundararajan, C., Honda, Y., Suh, N., Risingsong, R., Williams, C. R., Royce, D. B., Sporn, M. B., et al. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.09.012 · Cited by 48 · see citing works

Isopentenoids and Other Natural Products

Nes, W. D. (1994) · ACS symposium series · doi:10.1021/bk-1994-0562 · Cited by 47 · see citing works

The selective retinoid X receptor agonist bexarotene (LGD1069, Targretin) prevents and overcomes multidrug resistance in advanced breast carcinoma

Yen, W.-C., & Lamph, W. W. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0018 · Cited by 46 · see citing works

Synergistic effect of a retinoid X receptor-selective ligand bexarotene (LGD1069, Targretin) and paclitaxel (Taxol) in mammary carcinoma

Yen, W.-C., Prudente, R. Y., & Lamph, W. W. (2004) · Breast Cancer Research and Treatment · doi:10.1007/s10549-004-1426-5 · Cited by 46 · see citing works

A selective retinoid X receptor agonist bexarotene (LGD1069, Targretin) prevents and overcomes multidrug resistance in advanced prostate cancer

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The triterpenoid CDDO inhibits expression of matrix metalloproteinase-1, matrix metalloproteinase-13 and Bcl-3 in primary human chondrocytes

Elliott, S. F., Hays, E., Mayor, M. B., Sporn, M. B., & Vincenti, M. P. (2003) · Arthritis Research & Therapy · doi:10.1186/ar792 · Cited by 46 · see citing works

Identification of Biomarkers Modulated by the Rexinoid LGD1069 (Bexarotene) in Human Breast Cells Using Oligonucleotide Arrays

Kim, H.-T., Kong, G., DeNardo, D. G., Li, Y., Uray, I. P., Pal, S., Mohsin, S. K., Hilsenbeck, S. G., Bissonnette, R. P., Lamph, W. W., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2515 · Cited by 44 · see citing works

The synthetic triterpenoid CDDO-imidazolide induces monocytic differentiation by activating the Smad and ERK signaling pathways in HL60 leukemia cells

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Efficacy of Targretin on methylnitrosourea-induced mammary cancers: prevention and therapy dose-response curves and effects on proliferation and apoptosis

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Receptor-selective retinoids inhibit the growth of normal and malignant breast cells by inducing G1 cell cycle blockade

Wu, K., Dupre, E., Kim, H., Tin-U, C., Bissonnette, R. P., Lamph, W. W., & Brown, P. H. (2005) · Breast Cancer Research and Treatment · doi:10.1007/s10549-005-9071-1 · Cited by 39 · see citing works

Redox Modulation of Chemotherapy-Induced Tumor Cell Killing and Normal Tissue Toxicity

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Induction of adipocyte-specific gene expression is correlated with mammary tumor regression by the retinoid X receptor-ligand LGD1069 (targretin).

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Suppression of human pancreatic cancer cell proliferation by AGN194204, an RXR-selective retinoid

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Design, Synthesis, and Structure−Activity Relationship Studies of Novel 6,7-Locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic Acids

Michellys, P., Ardecky, R., Chen, J., D’Arrigo, J., Grese, T. A., Karanewsky, D. S., Leibowitz, M. D., Liu, S., Mais, D. E., Mapes, C. M., et al. (2003) · Journal of Medicinal Chemistry · doi:10.1021/jm020401k · Cited by 34 · see citing works

Prevention of lung cancer progression by bexarotene in mouse models

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The retinoid X receptor agonist bexarotene (Targretin) synergistically enhances the growth inhibitory activity of cytotoxic drugs in non-small cell lung cancer cells

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Triterpenoids

Connolly, J. D., & Hill, R. A. (2005) · Natural Product Reports · doi:10.1039/b501301c · Cited by 34 · see citing works

Peroxisome Proliferator-Activated Receptor-γ-Independent Repression of Collagenase Gene Expression by 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic Acid and Prostaglandin 15-Deoxy-Δ(12,14) J2: A Role for Smad Signaling

Mix, K. S., Coon, C. I., Rosen, E. D., Suh, N., Sporn, M. B., & Brinckerhoff, C. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.2.309 · Cited by 31 · see citing works

The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) induces apoptosis of human diffuse large B-cell lymphoma cells through a peroxisome proliferator-activated receptor γ-independent pathway

Ray, D. M., Morse, K. M., Hilchey, S. P., Garcia, T. M., Felgar, R. E., Maggirwar, S. B., Phipps, R. P., & Bernstein, S. H. (2006) · Experimental Hematology · doi:10.1016/j.exphem.2006.04.026 · Cited by 30 · see citing works

Dichotomies in cancer research: some suggestions for a new synthesis

Sporn, M. B. (2006) · Nature Clinical Practice Oncology · doi:10.1038/ncponc0536 · Cited by 29 · see citing works

Prevention of mouse lung tumors by targretin

Pereira, M. A., Kramer, P. M., Nines, R. G., Liu, Y., Alyaqoub, F. S., Gunning, W. T., Steele, V. E., & Lubet, R. A. (2005) · International Journal of Cancer · doi:10.1002/ijc.21618 · Cited by 27 · see citing works

The Novel Synthetic Oleanane Triterpenoid CDDO (2-cyano-3, 12-dioxoolean-1, 9-dien-28-oic acid) Induces Apoptosis in Mycosis Fungoides/Sézary Syndrome Cells

Zhang, C., Ni, X., Konopleva, M. Y., Andreeff, M., & Duvic, M. A. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.23207.x · Cited by 26 · see citing works

Design, synthesis and structure–activity relationship of novel RXR-selective modulators

Michellys, P., D’Arrigo, J., Grese, T. A., Karanewsky, D. S., Leibowitz, M. D., Mais, D. E., Mapes, C. M., Reifel-Miller, A. E., Rungta, D. K., & Boehm, M. F. (2004) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2003.12.089 · Cited by 26 · see citing works

A novel triterpenoid induces transforming growth factor β production by intraepithelial lymphocytes to prevent ileitis

Minns, L. A., Buzoni–Gatel, D., Ely, K. H., Rachinel, N., Luangsay, S., & Kasper, L. H. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.03.053 · Cited by 21 · see citing works

Nonclassical Retinoids and Lung Carcinogenesis

Dragnev, K. H., Petty, W. J., Ma, Y., Rigas, J. R., & Dmitrovsky, E. (2005) · Clinical Lung Cancer · doi:10.3816/clc.2005.n.003 · Cited by 19 · see citing works

2-Cyano-3,12-dioxooleana-1,9(11)-diene-28-oic Acid Disrupts Microtubule Polymerization: A Possible Mechanism Contributing to Apoptosis

Couch, R. D., Ganem, N. J., Zhou, M., Popov, V. M., Honda, T., Veenstra, T. D., Sporn, M. B., & Anderson, A. C. (2006) · Molecular Pharmacology · doi:10.1124/mol.105.018572 · Cited by 19 · see citing works

Triterpenoid CDDO-Im downregulates PML/RARα expression in acute promyelocytic leukemia cells

Ikeda, T., Kimura, F., Nakata, Y., Sato, K., Ogura, K., Motoyoshi, K., Sporn, M., & Kufe, D. W. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401574 · Cited by 19 · see citing works

Prospects for Plant-Derived Chemopreventive Agents Exhibiting Multiple Mechanisms of Action

Howells, L. M., & Manson, M. M. (2005) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1568011053765921 · Cited by 16 · see citing works

533 POSTER RTA 401 (CDDO) and RTA 402 (CDDO-Me), promising new anti-cancer agents that also prevent oral mucositis

Meyer, C., Ferguson, D. J. P., Watkins, B. A., Fey, E. G., & Sonis, S. T. (2006) · European Journal of Cancer Supplements · doi:10.1016/s1359-6349(06)70538-9 · Cited by 4 · see citing works

The synthetic triterpenoid, CDDO-Imidazolide blocks nuclear factor-κB activation through direct inhibition of IκB kinase-beta.

Yore, M. M., Liby, K. T., Honda, T., Gribble, G. T., & Sporn, M. B. (2006) · Cancer Epidemiology and Prevention Biomarkers · Cited by 4 · see citing works

The triterpenoid, CDDO-methyl ester, and the rexinoid, LG100268, synergize in the prevention of mammary tumors in a mouse model of estrogen receptor-negative breast cancer.

Liby, K. T., Royce, D. B., Risingsong, R., Williams, C. R., Honda, T., Gribble, G. W., Lamph, W. W., & Sporn, M. B. (2006) · Cancer Epidemiology and Prevention Biomarkers · Cited by 1 · see citing works

Role of nrf2 in oxidative stress and toxicity

Ma, Q. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140320 · Cited by 4,903 · see citing works

Reactive Oxygen Species in Inflammation and Tissue Injury

Mittal, M., Siddiqui, M. R., Tran, K., Reddy, S. P., & Malik, A. B. (2014) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2012.5149 · Cited by 4,897 · see citing works

Targeting mitochondria for cancer therapy

Fulda, S., Galluzzi, L., & Kroemer, G. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3137 · Cited by 1,638 · see citing works

NRF2 and cancer: the good, the bad and the importance of context

Sporn, M. B., & Liby, K. T. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3278 · Cited by 1,067 · see citing works

Natural products to drugs: natural product-derived compounds in clinical trials

Butler, M. S. (2008) · Natural Product Reports · doi:10.1039/b514294f · Cited by 1,075 · see citing works

Nrf2–ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases

Buendía, I., Michalska, P., Navarro, E., Gameiro‐Ros, I., Egea, J., & Leon, R. M. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.11.003 · Cited by 683 · see citing works

Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene

Saleem, M. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.04.033 · Cited by 641 · see citing works

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554 · see citing works

Metabolic and functional diversity of saponins, biosynthetic intermediates and semi-synthetic derivatives

Moses, T., Papadopoulou, K. Κ., & Osbourn, A. (2014) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2014.953628 · Cited by 559 · see citing works

Proteasome Inhibitors: An Expanding Army Attacking a Unique Target

Kisselev, A. F., van der Linden, W. A., & Overkleeft, H. S. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.01.003 · Cited by 528 · see citing works

RAR and RXR modulation in cancer and metabolic disease

Altucci, L., Leibowitz, M. D., Ogilvie, K. M., de Lera, A. R., & Gronemeyer, H. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2397 · Cited by 517 · see citing works

Oleanolic acid

Pollier, J., & Goossens, A. (2012) · Phytochemistry · doi:10.1016/j.phytochem.2011.12.022 · Cited by 505 · see citing works

Nrf2: friend or foe for chemoprevention?

Kensler, T. W., & Wakabayashi, N. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp231 · Cited by 487 · see citing works

The complexity of the Nrf2 pathway: beyond the antioxidant response

Huang, Y. S., Li, W., Su, Z., & Kong, A. T. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.08.001 · Cited by 449 · see citing works

Metabolic Diversification—Independent Assembly of Operon-Like Gene Clusters in Different Plants

Field, B., & Osbourn, A. (2008) · Science · doi:10.1126/science.1154990 · Cited by 425 · see citing works

Synthetic Oleanane Triterpenoids: Multifunctional Drugs with a Broad Range of Applications for Prevention and Treatment of Chronic Disease

Liby, K. T., & Sporn, M. B. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.004846 · Cited by 410 · see citing works

Neuroprotective strategies involving ROS in Alzheimer disease

Dumont, M., & Beal, M. F. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.11.026 · Cited by 402 · see citing works

Triterpenoids as new promising anticancer drugs

Petronelli, A., Pannitteri, G., & Testa, U. (2009) · Anti-Cancer Drugs · doi:10.1097/cad.0b013e328330fd90 · Cited by 382 · see citing works

Role of Polyphenols and Other Phytochemicals on Molecular Signaling

Upadhyay, S., & Dixit, M. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/504253 · Cited by 382 · see citing works

Beneficial health effects of lupeol triterpene: A review of preclinical studies

Siddique, H. R., & Saleem, M. (2010) · Life Sciences · doi:10.1016/j.lfs.2010.11.020 · Cited by 370 · see citing works

Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice

Lu, T., Ramakrishnan, R., Altiok, S., Youn, J. I., Cheng, P., Celis, E., Писарев, В. М., Sherman, S., Sporn, M. B., & Gabrilovich, D. I. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45862 · Cited by 365 · see citing works

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

Kell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361 · see citing works

Terpenoids as potential chemopreventive and therapeutic agents in liver cancer

Thoppil, R. J. (2011) · World Journal of Hepatology · doi:10.4254/wjh.v3.i9.228 · Cited by 354 · see citing works

Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

Sussan, T. E., Rangasamy, T., Blake, D. J., Malhotra, D., El-Haddad, H., Bedja, D., Yates, M. S., Kombairaju, P., Yamamoto, M., Liby, K. T., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804333106 · Cited by 346 · see citing works

Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea

Sato, H., Genet, C., Strehle, A., Thomas, C., Lobstein, A., Wagner, A., Mioskowski, C., Auwerx, J. H., & Saladin, R. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.06.130 · Cited by 341 · see citing works

Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer

Bishayee, A. (2010) · Frontiers in bioscience · doi:10.2741/3730 · Cited by 332 · see citing works

Ursolic acid in cancer prevention and treatment: Molecular targets, pharmacokinetics and clinical studies

Shanmugam, M. K., Dai, X., Kumar, A. P., Tan, B. K. H., Sethi, G., & Bishayee, A. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.03.006 · Cited by 329 · see citing works

Molecular Basis of Electrophilic and Oxidative Defense: Promises and Perils of Nrf2

Ma, Q., & He, X. (2012) · Pharmacological Reviews · doi:10.1124/pr.110.004333 · Cited by 317 · see citing works

Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

Bharadwaj, U., Kasembeli, M. M., Robinson, P., & Tweardy, D. J. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018440 · Cited by 314 · see citing works

New Synthetic Triterpenoids: Potent Agents for Prevention and Treatment of Tissue Injury Caused by Inflammatory and Oxidative Stress

Sporn, M. B., Liby, K. T., Yore, M. M., Fu, L., Lopchuk, J. M., & Gribble, G. W. (2011) · Journal of Natural Products · doi:10.1021/np100826q · Cited by 312 · see citing works

Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

Wang, X. J., Hayes, J. D., Henderson, C. J., & Wolf, C. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709483104 · Cited by 310 · see citing works

Betulin and betulinic acid: triterpenoids derivatives with a powerful biological potential

Hordyjewska, A., Ostapiuk, A., Horecka, A., & Kurzepa, J. (2019) · Phytochemistry Reviews · doi:10.1007/s11101-019-09623-1 · Cited by 301 · see citing works

Mitochondrial Approaches for Neuroprotection

Chaturvedi, R. K., & Beal, M. F. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.027 · Cited by 294 · see citing works

Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases

Sheng, H., & Sun, H. (2011) · Natural Product Reports · doi:10.1039/c0np00059k · Cited by 290 · see citing works

N-acetylcysteine, reactive oxygen species and beyond

Sun, S. (2010) · Cancer Biology & Therapy · doi:10.4161/cbt.9.2.10583 · Cited by 290 · see citing works

Anti-inflammatory Triterpenoid Blocks Immune Suppressive Function of MDSCs and Improves Immune Response in Cancer

Nagaraj, S., Youn, J., Weber, H., Iclozan, C., Lu, L. D., Cotter, M. J., Meyer, C. J., Becerra, C. R., Fishman, M., Antonia, S. J., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-3272 · Cited by 286 · see citing works

The saponins – polar isoprenoids with important and diverse biological activities

Osbourn, A., Goss, R. J. M., & Field, R. A. (2011) · Natural Product Reports · doi:10.1039/c1np00015b · Cited by 282 · see citing works

Myeloid derived suppressor cells—An overview of combat strategies to increase immunotherapy efficacy

Draghiciu, O., Lubbers, J. M., Nijman, H. W., & Daemen, T. (2014) · OncoImmunology · doi:10.4161/21624011.2014.954829 · Cited by 274 · see citing works

An Overview of Potential Seaweed-Derived Bioactive Compounds for Pharmaceutical Applications

Lomartire, S., & Gonçalves, A. M. M. (2022) · Marine Drugs · doi:10.3390/md20020141 · Cited by 290 · see citing works

Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice

Yates, M. S., Tran, Q. T., Dolan, P. M., Osburn, W. O., Shin, S., McCulloch, C. C., Silkworth, J. B., Taguchi, K., Yamamoto, M. P., Williams, C. R., et al. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp100 · Cited by 269 · see citing works

Mitochondrial Quality Control as a Therapeutic Target

Suliman, H. B., & Piantadosi, C. A. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.011502 · Cited by 265 · see citing works

Functions, Therapeutic Applications, and Synthesis of Retinoids and Carotenoids

Álvarez, R., Vaz, B., Gronemeyer, H., & de Lera, Á. R. (2014) · Chemical Reviews · doi:10.1021/cr400126u · Cited by 260 · see citing works

Bioengineering of plant (tri)terpenoids: from metabolic engineering of plants to synthetic biology <i>in vivo</i> and <i>in vitro</i>

Moses, T., Pollier, J., Thevelein, J. M., & Goossens, A. (2013) · New Phytologist · doi:10.1111/nph.12325 · Cited by 245 · see citing works

Molecular mechanisms of natural products in chemoprevention: Induction of cytoprotective enzymes by Nrf2

Eggler, A. L., Gay, K. A., & Mesecar, A. D. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700249 · Cited by 234 · see citing works

Terpenoids and breast cancer chemoprevention

Rabi, T., & Bishayee, A. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-008-0118-y · Cited by 235 · see citing works

Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties

Zhou, S.-F., Wang, Y., Zhe, H., Yang, Y., & He, Z. (2014) · Drug Design Development and Therapy · doi:10.2147/dddt.s68872 · Cited by 230 · see citing works

Myeloid-Derived Suppressor Cells in Human Cancer

Nagaraj, S., & Gabrilovich, D. I. (2010) · The Cancer Journal · doi:10.1097/ppo.0b013e3181eb3358 · Cited by 222 · see citing works

Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer

Shanmugam, M. K., Nguyen, A. H., Kumar, A. P., Tan, B. K. H., & Sethi, G. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.02.037 · Cited by 220 · see citing works

Nrf2: control of sensitivity to carcinogens

Slocum, S. L., & Kensler, T. W. (2011) · Archives of Toxicology · doi:10.1007/s00204-011-0675-4 · Cited by 219 · see citing works

Recent progress in the antiviral activity and mechanism study of pentacyclic triterpenoids and their derivatives

Xiao, S., Tian, Z., Wang, Y., Si, L., Zhang, L., & Zhou, D. (2018) · Medicinal Research Reviews · doi:10.1002/med.21484 · Cited by 212 · see citing works

Modulation of Apoptosis by Natural Products for Cancer Therapy

Fulda, S. (2010) · Planta Medica · doi:10.1055/s-0030-1249961 · Cited by 213 · see citing works

Targeting mitochondrial apoptosis by betulinic acid in human cancers

Fulda, S., & Kroemer, G. (2009) · Drug Discovery Today · doi:10.1016/j.drudis.2009.05.015 · Cited by 199 · see citing works

Betulinic acid, a natural compound with potent anticancer effects

Mullauer, F. B., Kessler, J. H., & Medema, J. P. (2010) · Anti-Cancer Drugs · doi:10.1097/cad.0b013e3283357c62 · Cited by 198 · see citing works

Naturally Occurring Pentacyclic Triterpenes as Inhibitors of Glycogen Phosphorylase: Synthesis, Structure−Activity Relationships, and X-ray Crystallographic Studies

Wen, X., Sun, H., Liu, J., Cheng, K., Zhang, P., Zhang, L., Jia, H., Zhang, L., Ni, P., Zographos, S. E., et al. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm8000949 · Cited by 191 · see citing works

Cancer prevention and treatment using combination therapy with natural compounds

Sauter, E. R. (2020) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2020.1738218 · Cited by 187 · see citing works

Nrf2 links epidermal barrier function with antioxidant defense

Schäfer, M., Farwanah, H., Willrodt, A., Huebner, A. J., Sandhoff, K., Roop, D. R., Hohl, D., Bloch, W., & Werner, S. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201200219 · Cited by 186 · see citing works

Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration

Cano, M., Thimmalappula, R., Fujihara, M., Nagai, N., Sporn, M. B., Wang, A. L., Neufeld, A. H., Biswal, S. S., & Handa, J. T. (2009) · Vision Research · doi:10.1016/j.visres.2009.08.018 · Cited by 185 · see citing works

The Nrf2/ARE Pathway: A Promising Target to Counteract Mitochondrial Dysfunction in Parkinson's Disease

Tüfekçi, K. U., Bayin, E. C., Genç, Ş., & Genç, K. (2011) · Parkinson s Disease · doi:10.4061/2011/314082 · Cited by 181 · see citing works

A Comprehensive Review of the Structure Elucidation and Biological Activity of Triterpenoids from Ganoderma spp.

Xia, Q., Zhang, H., Sun, X., Zhao, H., Wu, L., Zhu, D., Yang, G., Shao, Y., Zhang, X., Mao, X., et al. (2014) · Molecules · doi:10.3390/molecules191117478 · Cited by 181 · see citing works

NADPH Oxidase Limits Innate Immune Responses in the Lungs in Mice

Segal, B. H., Han, W., Bushey, J. J., Joo, M., Bhatti, Z., Feminella, J., Dennis, C. G., Vethanayagam, R. R., Yull, F. E., Capitano, M. L., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009631 · Cited by 180 · see citing works

Molecular Mechanism of Inhibition of the Human Protein Complex Hsp90–Cdc37, a Kinome Chaperone–Cochaperone, by Triterpene Celastrol

Sreeramulu, S., Gande, S. L., Göbel, M., & Schwalbe, H. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200900929 · Cited by 179 · see citing works

Discovery and development of natural product oridonin-inspired anticancer agents

Ding, Y., Ding, C., Ye, N., Liu, Z., Wold, E. A., Chen, H., Wild, C., Shen, Q., & Zhou, J. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.06.015 · Cited by 178 · see citing works

Neuroprotective Effects of the Triterpenoid, CDDO Methyl Amide, a Potent Inducer of Nrf2-Mediated Transcription

Yang, L., Calingasan, N. Y., Thomas, B., Chaturvedi, R. K., Kiaei, M., Wille, E. J., Liby, K. T., Williams, C. R., Royce, D. B., Risingsong, R., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005757 · Cited by 172 · see citing works

A Serine Carboxypeptidase-Like Acyltransferase Is Required for Synthesis of Antimicrobial Compounds and Disease Resistance in Oats

Mugford, S. T., Qi, X., Bakht, S., Hill, L. M., Wegel, E., Hughes, R. K., Papadopoulou, K. Κ., Melton, R. E., Philo, M. R., Sainsbury, F., et al. (2009) · The Plant Cell · doi:10.1105/tpc.109.065870 · Cited by 172 · see citing works

Targeting the Nrf2 pathway against cardiovascular disease

Li, J., Ichikawa, T., Janicki, J. S., & Cui, T. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903025762 · Cited by 168 · see citing works

Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease

Stack, C., Ho, D. J., Wille, E. J., Calingasan, N. Y., Williams, C. R., Liby, K. T., Sporn, M. B., Dumont, M., & Beal, M. F. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.03.017 · Cited by 171 · see citing works

Targeting Nrf2-Mediated Gene Transcription by Extremely Potent Synthetic Triterpenoids Attenuate Dopaminergic Neurotoxicity in the MPTP Mouse Model of Parkinson's Disease

Kaidery, N. A., Banerjee, R., Yang, L., Smirnova, N. A., Hushpulian, D. M., Liby, K. T., Williams, C. R., Yamamoto, M. P., Kensler, T. W., Ratan, R. R., et al. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4491 · Cited by 172 · see citing works

Plant-derived triterpenoids and analogues as antitumor and anti-HIV agents

Kuo, R.-Y., Qian, K., Morris-Natschke, S. L., & Lee, K. (2009) · Natural Product Reports · doi:10.1039/b810774m · Cited by 169 · see citing works

How does the macula protect itself from oxidative stress?

Handa, J. T. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.03.006 · Cited by 154 · see citing works

Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment

Salvador, J. A. R., Leal, A. S., Valdeira, A. S. C., Gonçalves, B. M. F., Alho, D. P. S., Figueiredo, S. A. C., Silvestre, S., & Mendes, V. I. S. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.07.013 · Cited by 160 · see citing works

Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARγ, and HO-1

Wu, Q., Wang, Y., Senitko, M., Meyer, C. J., Wigley, W. C., Ferguson, D. A., Grossman, E. B., Chen, J., Zhou, X. J., Hartono, J. R., et al. (2011) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00353.2010 · Cited by 158 · see citing works

Using the Heat-Shock Response To Discover Anticancer Compounds that Target Protein Homeostasis

Santagata, S., Xu, Y.-M., Wijeratne, E. M. K., Kontnik, R., Rooney, C., Perley, C. C., Kwon, H., Clardy, J., Kesari, S., Whitesell, L. J., et al. (2011) · ACS Chemical Biology · doi:10.1021/cb200353m · Cited by 147 · see citing works

Modulation of RXR function through ligand design

Pérez, E., Bourguet, W., Gronemeyer, H., & de Lera, A. R. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.04.003 · Cited by 169 · see citing works

Nrf2 has a protective role against neuronal and capillary degeneration in retinal ischemia–reperfusion injury

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Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function

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