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Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

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Sletten, Ellen M., Bertozzi, Carolyn R.·2009·Angewandte Chemie International Edition

DOI 10.1002/anie.200900942PMC PMC2864149

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Abstract

The study of biomolecules in their native environments is a challenging task because of the vast complexity of cellular systems. Technologies developed in the last few years for the selective modification of biological species in living systems have yielded new insights into cellular processes. Key to these new techniques are bioorthogonal chemical reactions, whose components must react rapidly and selectively with each other under physiological conditions in the presence of the plethora of functionality necessary to sustain life. Herein we describe the bioorthogonal chemical reactions developed to date and how they can be used to study biomolecules.

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Authors: Sletten, E. M., & Bertozzi, C. R.
Affiliations: University of California, Berkeley (US)
Howard Hughes Medical Institute (US)
Corresponding author: Bertozzi, Carolyn R.
ORCID: Sletten, Ellen M.
Bertozzi, Carolyn R.
Venue: Angewandte Chemie International Edition
Publisher: Wiley
Published: 2009-09
Volume: 48
Issue: 38
Pages: 6974-6998
ISSN: 1433-7851 (ISSN-L)
1521-3773
DOI: 10.1002/anie.200900942
PMC: PMC2864149
OpenAlex: W2151709132
Cited by: 3,165
References: 362
Citations by year: 2026: 160 · 2025: 174 · 2024: 189 · 2023: 223 · 2022: 173 · 2021: 192 · 2020: 185 · 2019: 200 · 2018: 230 · 2017: 196 · 2016: 193 · 2015: 200 · 2014: 233 · 2013: 194 · 2012: 143
FWCI: 68.06
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Angewandte Chemie International Edition (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
National Institute of General Medical Sciences (R37GM058867)
Topics: Physical Sciences › Chemistry › Organic Chemistry › Click Chemistry and Applications
Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Biotin and Related Studies
Keywords: bioorthogonal chemistry, bioorthogonal reactions, biological systems, cellular processes
MeSH terms: Alkynes, Animals, Azides, Biochemical Phenomena, Biochemistry, Fluorescent Dyes, Humans, Indicators and Reagents, Molecular Sequence Data, Staining and Labeling, Molecular Structure, Cellular Structures, Green Fluorescent Proteins

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Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

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