The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Challenge of Atropisomerism in Drug Discovery
Abstract
A twist in the tale: Recent reports have highlighted solutions to the problems encountered when drug candidates exist as slowly interconverting conformers or atropisomers (see scheme). This Minireview brings together the various strategies that have been adopted and proposes a general approach to handling an aspect of stereochemistry which has received little attention from drug regulatory agencies.
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Citations
Cites
Putting chirality to work: the strategy of chiral switches
Agranat, I., Caner, H., & Caldwell, J. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd915 · Cited by 637
Cited by
Johnson, T. W., Richardson, P. F., Bailey, S., Brooun, A., Burke, B. J., Collins, M. R., Cui, J. J., Deal, J. G., Deng, Y.-L., Dinh, D., et al. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm500261q · Cited by 594
General Enantioselective C−H Activation with Efficiently Tunable Cyclopentadienyl Ligands
Jia, Z., Merten, C., Gontla, R., Daniliuc, C. G., Antonchick, A. P., & Waldmann, H. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201611981 · Cited by 336
Metadata
- Authors
- Clayden, J., Moran, W. J., Edwards, P. J., & LaPlante, S. R.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2009-08-12
- Volume
- 48
- Issue
- 35
- Pages
- 6398-6401
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2122839730
- Cited by
- 783
- References
- 1
- FWCI
- 9.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Challenge of Atropisomerism in Drug Discovery. https://app.cochat.ai/papers/10.1002/anie.200901719
- The paper
- Clayden, J., Moran, W. J., Edwards, P. J., & LaPlante, S. R. (2009). The Challenge of Atropisomerism in Drug Discovery. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.200901719
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
