Cited by 644Analytical Chemistry and ChromatographyChemistry and Stereochemistry StudiesAsymmetric Synthesis and Catalysis

Putting chirality to work: the strategy of chiral switches

Agranat, Israel, Caner, Hava, Caldwell, John·2002·Nature Reviews Drug Discovery

Abstract

Most of the new drugs reaching the market today are single enantiomers, rather than the racemic mixtures that dominated up to ten years ago. Many of the new single-enantiomer drugs were developed as such, but there are also important examples of new single-enantiomer drugs derived from 'chiral switches' of established racemates. Indeed, a well-timed chiral switch can offer enhanced therapy and further profitability as a 'line extension' of a major racemic drug with patents that are expiring.

Integrity signals

Registry

Crossref · 10.1038/nrd915

Cites

77 of 77 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

23 of the 100 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Agranat, I., Caner, H., & Caldwell, J.
Affiliations
  • Hebrew University of Jerusalem (IL)
  • Imperial College London (GB)
Corresponding author
Agranat, Israel
Venue
Nature Reviews Drug Discovery
Published
2002-10
Volume
1
Issue
10
Pages
753-768
ISSN
  • 1474-1776 (ISSN-L)
  • 1474-1784
OpenAlex
W1991998089
Cited by
637
References
100
Citations by year
2026: 32 · 2025: 31 · 2024: 43 · 2023: 29 · 2022: 31 · 2021: 36 · 2020: 33 · 2019: 32 · 2018: 32 · 2017: 31 · 2016: 15 · 2015: 31 · 2014: 25 · 2013: 22 · 2012: 32
FWCI
1.67
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Drug Discovery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Chemistry › Spectroscopy › Analytical Chemistry and Chromatography
  • Physical Sciences › Chemistry › Organic Chemistry › Chemistry and Stereochemistry Studies
  • Physical Sciences › Chemistry › Organic Chemistry › Asymmetric Synthesis and Catalysis
Keywords
chiral switch, racemic drugs, enantiomers, drug development strategy, line extension, patent expiry, pharmaceutical patents
MeSH terms
Animals, Chemistry, Pharmaceutical, Humans, Stereoisomerism, Technology, Pharmaceutical

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review