The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.
Metabolic features of chronic fatigue syndrome
Open accessAbstract
Significance: Chronic fatigue syndrome is a multisystem disease that causes long-term pain and disability. It is difficult to diagnose because of its protean symptoms and the lack of a diagnostic laboratory test. We report that targeted, broad-spectrum metabolomics of plasma not only revealed a characteristic chemical signature but also revealed an unexpected underlying biology. Metabolomics showed that chronic fatigue syndrome is a highly concerted hypometabolic response to environmental stress that traces to mitochondria and was similar to the classically studied developmental state of dauer. This discovery opens a fresh path for the rational development of new therapeutics and identifies metabolomics as a powerful tool to identify the chemical differences that contribute to health and disease.
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Cites
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The Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study
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“It has recently been shown that mitochondrial MTHFD2L is responsible for producing 20–40% of cellular NADPH by the oxidation of methylene tetrahydrofolic acid to 10-formyl tetrahydrofolate (51).”
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Chronic viral infections in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
the European Network on ME/CFS (EUROMENE), Rasa, S., Nora-Krukle, Z., Henning, N., Eliassen, E., Shikova, E., Harrer, T., Scheibenbogen, C., Murovska, M., & Prusty, B. K. (2018) · Journal of Translational Medicine · doi:10.1186/s12967-018-1644-y · Cited by 312
Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome
Paul, B. D., Lemle, M. D., Komaroff, A. L., & Snyder, S. H. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2024358118 · Cited by 267
Will COVID-19 Lead to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?
Komaroff, A. L., & Bateman, L. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2020.606824 · Cited by 259
Komaroff, A. L., & Lipkin, W. I. (2021) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2021.06.002 · Cited by 259
Fluge, Ø., Mella, O., Bruland, O., Risa, K., Dyrstad, S. E., Alme, K., Rekeland, I. G., Sapkota, D., Røsland, G. V., Fosså, A., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.89376 · Cited by 209
Metadata
- Authors
- Naviaux, R. K., Naviaux, J. C., Li, K., Bright, A. T., Alaynick, W. A., Wang, L., Baxter, A., Nathan, N., Anderson, W., & Gordon, E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2016-08-29
- Volume
- 113
- Issue
- 37
- Pages
- E5472-80
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2509132807
- Cited by
- 391
- References
- 89
- FWCI
- 27.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Naviaux, R. K., Naviaux, J. C., Li, K., Bright, A. T., Alaynick, W. A., Wang, L., Baxter, A., Nathan, N., Anderson, W., & Gordon, E. (2016). Metabolic features of chronic fatigue syndrome. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1607571113
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