The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Targeted Metabolomics for Biomarker Discovery
Abstract
Metabolomics is a truly interdisciplinary field of science, which combines analytical chemistry, platform technology, mass spectrometry, and NMR spectroscopy with sophisticated data analysis. Applied to biomarker discovery, it includes aspects of pathobiochemistry, systems biology/medicine, and molecular diagnostics and requires bioinformatics and multivariate statistics. While successfully established in the screening of inborn errors in neonates, metabolomics is now widely used in the characterization and diagnostic research of an ever increasing number of diseases. In this Review we highlight important technical prerequisites as well as recent developments in metabolomics and metabolomics data analysis with special emphasis on their utility in biomarker identification and qualification, as well as targeted metabolomics by employing high‐throughput mass spectrometry.
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Cites
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Cited by
Zhou, B., Xiao, J. F., Tuli, L., & Ressom, H. W. (2011) · Molecular BioSystems · doi:10.1039/c1mb05350g · Cited by 639
Metabolite identification and quantitation in LC-MS/MS-based metabolomics
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Mass spectrometric based approaches in urine metabolomics and biomarker discovery
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Botticelli, A., Vernocchi, P., Marini, F., Quagliariello, A., Cerbelli, B., Reddel, S., Del Chierico, F., Di Pietro, F., Giusti, R., Tomassini, A., et al. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02231-0 · Cited by 209
Biomarkers intersect with the exposome
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Metadata
- Authors
- Griffiths, W. J., Koal, T., Wang, Y., Kohl, M., Enot, D. P., & Deigner, H.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2010-07-22
- Volume
- 49
- Issue
- 32
- Pages
- 5426-5445
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2006691834
- Cited by
- 415
- References
- 13
- FWCI
- 8.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Griffiths, W. J., Koal, T., Wang, Y., Kohl, M., Enot, D. P., & Deigner, H. (2010). Targeted Metabolomics for Biomarker Discovery. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.200905579
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