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Cited by 460

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Polymeric Multilayer Capsules in Drug Delivery

De Cock, Liesbeth J., De Koker, Stefaan, De Geest, Bruno G., Grooten, Johan, Vervaet, Chris, Remon, Jean Paul, Sukhorukov, Gleb B., Antipina, Maria N.·2010·Angewandte Chemie International Edition

Abstract

Recent advances in medicine and biotechnology have prompted the need to develop nanoengineered delivery systems that can encapsulate a wide variety of novel therapeutics such as proteins, chemotherapeutics, and nucleic acids. Moreover, these delivery systems should be “intelligent”, such that they can deliver their payload at a well‐defined time, place, or after a specific stimulus. Polymeric multilayer capsules, made by layer‐by‐layer (LbL) coating of a sacrificial template followed by dissolution of the template, allow the design of microcapsules in aqueous conditions by using simple building blocks and assembly procedures, and provide a previously unmet control over the functionality of the microcapsules. Polymeric multilayer capsules have recently received increased interest from the life science community, and many interesting systems have appeared in the literature with biodegradable components and biospecific functionalities. In this Review we give an overview of the recent breakthroughs in their application for drug delivery.

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Metadata

Authors
De Cock, L. J., De Koker, S., De Geest, B. G., Grooten, J., Vervaet, C., Remon, J. P., Sukhorukov, G. B., & Antipina, M. N.
Venue
Angewandte Chemie International Edition
Publisher
Wiley
Published
2010-07-19
Volume
49
Issue
39
Pages
6954-6973
ISSN
  • 1433-7851 (ISSN-L)
  • 1521-3773
OpenAlex
W2145479159
Cited by
460
References
1
FWCI
18.19
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Polymeric Multilayer Capsules in Drug Delivery. https://app.cochat.ai/papers/10.1002/anie.200906266
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De Cock, L. J., De Koker, S., De Geest, B. G., Grooten, J., Vervaet, C., Remon, J. P., Sukhorukov, G. B., & Antipina, M. N. (2010). Polymeric Multilayer Capsules in Drug Delivery. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.200906266

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