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Synthesis of 64CuII–Bis(dithiocarbamatebisphosphonate) and Its Conjugation with Superparamagnetic Iron Oxide Nanoparticles: In Vivo Evaluation as Dual‐Modality PET–MRI Agent
Open accessAbstract
A novel bifunctional chelator combines a dithiocarbamate group for binding the positron-emitter 64Cu (red spheres) for PET imaging and a bisphosphonate group (green ellipsoids) for strong binding to several inorganic materials, such as MRI contrast agents based on superparamagnetic iron oxide nanoparticles and rare-earth metal oxides. The dual PET–MR imaging capabilities of this approach are demonstrated in vivo by imaging lymph nodes using both imaging modalities.
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MCCARTHY, J., & WEISSLEDER, R. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.03.014 · Cited by 892
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Smith, B. R., & Gambhir, S. S. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00073 · Cited by 1,075
Covalent Surface Modification of Oxide Surfaces
Pujari, S. P., Scheres, L., Marcelis, A. T. M., & Zuilhof, H. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201306709 · Cited by 934
Surface Modification Using Phosphonic Acids and Esters
Queffélec, C., Petit, M., Janvier, P., Knight, D. A., & Bujoli, B. (2012) · Chemical Reviews · doi:10.1021/cr2004212 · Cited by 868
A smart and versatile theranostic nanomedicine platform based on nanoporphyrin
Li, Y., Lin, T.-Y., Luo, Y., Liu, Q., Xiao, W., Guo, W., Lac, D., Zhang, H., Feng, C., Wachsmann-Hogiu, S., et al. (2014) · Nature Communications · doi:10.1038/ncomms5712 · Cited by 414
Precise nanomedicine for intelligent therapy of cancer
Chen, H., Gu, Z., An, H., Chen, C., Chen, J., Cui, R., Chen, S., Chen, W., Chen, X., Chen, X., et al. (2018) · Science China Chemistry · doi:10.1007/s11426-018-9397-5 · Cited by 409
Metadata
- Authors
- Torres Martin de Rosales, R., Tavaré, R., Paul, R. L., Jauregui‐Osoro, M., Protti, A., Glaria, A., Varma, G., Szanda, I., & Blower, P. J.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2011-05-04
- Volume
- 50
- Issue
- 24
- Pages
- 5509-5513
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2115141253
- Cited by
- 181
- References
- 2
- FWCI
- 10.57
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Synthesis of 64CuII–Bis(dithiocarbamatebisphosphonate) and Its Conjugation with Superparamagnetic Iron Oxide Nanoparticles: In Vivo Evaluation as Dual‐Modality PET–MRI Agent. https://app.cochat.ai/papers/10.1002/anie.201007894
- The paper
- Torres Martin de Rosales, R., Tavaré, R., Paul, R. L., Jauregui‐Osoro, M., Protti, A., Glaria, A., Varma, G., Szanda, I., & Blower, P. J. (2011). Synthesis of 64CuII–Bis(dithiocarbamatebisphosphonate) and Its Conjugation with Superparamagnetic Iron Oxide Nanoparticles: In Vivo Evaluation as Dual‐Modality PET–MRI Agent. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201007894
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