The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
A smart and versatile theranostic nanomedicine platform based on nanoporphyrin
Open accessAbstract
Multifunctional nanoparticles with combined diagnostic and therapeutic functions show great promise towards personalized nanomedicine. However, attaining consistently high performance of these functions in vivo in one single nanoconstruct remains extremely challenging. Here we demonstrate the use of one single polymer to develop a smart ‘all-in-one’ nanoporphyrin platform that conveniently integrates a broad range of clinically relevant functions. Nanoporphyrins can be used as amplifiable multimodality nanoprobes for near-infrared fluorescence imaging (NIRFI), magnetic resonance imaging (MRI), positron emission tomography (PET) and dual modal PET-MRI. Nanoporphyrins greatly increase the imaging sensitivity for tumour detection through background suppression in blood, as well as preferential accumulation and signal amplification in tumours. Nanoporphyrins also function as multiphase nanotransducers that can efficiently convert light to heat inside tumours for photothermal therapy (PTT), and light to singlet oxygen for photodynamic therapy (PDT). Furthermore, nanoporphyrins act as programmable releasing nanocarriers for targeted delivery of drugs or therapeutic radio-metals into tumours. Nanoparticles can be used for therapeutic and diagnostic purposes. Here, the authors report that nanoparticles made of a single chemical building block, called nanoporphyrins, incorporate eight different functionalities, including various types of imaging, drug delivery and cancer therapy.
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Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
Michalet, X., Pinaud, F. F., Bentolila, L. A., Tsay, J. M., Doose, S., Li, J. J., Sundaresan, G., Wu, A. M., Gambhir, S. S., & Weiss, S. (2005) · Science · doi:10.1126/science.1104274 · Cited by 7,790
Laurent, S., Forge, D., Port, M., Roch, A., Robic, C., Vander Elst, L., & Muller, R. N. (2008) · Chemical Reviews · doi:10.1021/cr068445e · Cited by 6,852
Photodynamic therapy of cancer: An update
Agostinis, P., Berg, K., Cengel, K. A., Foster, T. H., Girotti, A. W., Gollnick, S. O., Hahn, S. M., Hamblin, M. R., Juzeniene, A., Kessel, D., et al. (2011) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20114 · Cited by 5,145
Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
Cabral, H., Matsumoto, Y., Mizuno, K., Chen, Q., Murakami, M., Kimura, M., Terada, Y., Kano, M. R., Miyazono, K., Uesaka, M., et al. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.166 · Cited by 2,429
Mahmoudi, M., Sant, S., Wang, B., Laurent, S., & Sen, T. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.05.006 · Cited by 1,881
Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles
O'Neal, D. P., Hirsch, L. R., Halas, N. J., Payne, J. D., & West, J. L. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.02.004 · Cited by 1,849
In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers
Idris, N. M., Gnanasammandhan, M. K., Zhang, J., Ho, P. C., Mahendran, R., & Zhang, Y. (2012) · Nature Medicine · doi:10.1038/nm.2933 · Cited by 1,464
Nanoparticle-based theranostic agents
Xie, J., Lee, S., & Chen, X. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.07.009 · Cited by 1,422
Multifunctional nanoparticles for multimodal imaging and theragnosis
Lee, D.-E., Koo, H., Sun, I.-C., Ryu, J. H., Kim, K., & Kwon, I. C. (2012) · Chem. Soc. Rev. · doi:10.1039/c2cs15261d · Cited by 1,410
Lovell, J. F., Jin, C. S., Huynh, E., Jin, H., Kim, C., Rubinstein, J. L., Chan, W. C. W., Cao, W., Wang, L. V., & Zheng, G. (2011) · Nature Materials · doi:10.1038/nmat2986 · Cited by 1,362
Cited by
Polymer–drug conjugate therapeutics: advances, insights and prospects
Ekladious, I., Colson, Y. L., & Grinstaff, M. W. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-018-0005-0 · Cited by 855
Espinosa, A., Di Corato, R., Kolosnjaj-Tabi, J., Flaud, P., Pellegrino, T., & Wilhelm, C. (2016) · ACS Nano · doi:10.1021/acsnano.5b07249 · Cited by 788
Wang, S., Li, X., Chen, Y., Cai, X., Yao, H., Gao, W., Zheng, Y., An, X., Shi, J., & Chen, H. (2015) · Advanced Materials · doi:10.1002/adma.201500870 · Cited by 438
Supramolecular cancer nanotheranostics
Zhou, J., Rao, L., Yu, G., Cook, T. R., Chen, X., & Huang, F. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00011f · Cited by 411
Metadata
- Authors
- Li, Y., Lin, T.-Y., Luo, Y., Liu, Q., Xiao, W., Guo, W., Lac, D., Zhang, H., Feng, C., Wachsmann-Hogiu, S., Walton, J. H., Cherry, S. R., Rowland, D. J., Kukis, D., Pan, C., & Lam, K. S.
- Venue
- Nature Communications
- Published
- 2014-08-26
- Volume
- 5
- Issue
- 1
- Pages
- 4712-4712
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W1999313400
- Cited by
- 414
- References
- 51
- FWCI
- 22.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Li, Y., Lin, T.-Y., Luo, Y., Liu, Q., Xiao, W., Guo, W., Lac, D., Zhang, H., Feng, C., Wachsmann-Hogiu, S., Walton, J. H., Cherry, S. R., Rowland, D. J., Kukis, D., Pan, C., & Lam, K. S. (2014). A smart and versatile theranostic nanomedicine platform based on nanoporphyrin. Nature Communications. https://doi.org/10.1038/ncomms5712
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