Cited by 892Characterization and Applications of Magnetic NanoparticlesNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranostics

Multifunctional magnetic nanoparticles for targeted imaging and therapy

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MCCARTHY, J, WEISSLEDER, R·2008·Advanced Drug Delivery Reviews

Abstract

Magnetic nanoparticles have become important tools for the imaging of prevalent diseases, such as cancer, atherosclerosis, diabetes, and others. While first generation nanoparticles were fairly nonspecific, newer generations have been targeted to specific cell types and molecular targets via affinity ligands. Commonly, these ligands emerge from phage or small molecule screens, or are based on antibodies or aptamers. Secondary reporters and combined therapeutic molecules have further opened potential clinical applications of these materials. This review summarizes some of the recent biomedical applications of these newer magnetic nanomaterials.

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Crossref · 10.1016/j.addr.2008.03.014

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  • Upon surface modification, superparamagnetic iron oxide nanoparticles (SPION) can be employed for magnetic resonance imaging, magnetic particle imaging, targeted delivery of drugs, proteins, antibodies and nucleic acids, hyperthermia, biosensing, tissue repair, and separation of biomolecules.

    “Upon surface-modification, the resulting superparamagnetic iron oxide nanoparticles (SPION) can be employed for magnetic resonance imaging (MRI) [4–8], magnetic particle imaging (MPI) [9–12], targeted delivery of drugs, proteins, antibodies, and nucleic acids [6, 7, 13, 14], hyperthermia [15–17], biosensing [18], tissue repair [19], and separation of biomolecules [20].”

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Authors
MCCARTHY, J., & WEISSLEDER, R.
Affiliations
Harvard University (US)
Corresponding author
MCCARTHY, J
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
2008-08-17
Volume
60
Issue
11
Pages
1241-1251
ISSN
0169-409X (ISSN-L)
OpenAlex
W2154964751
Cited by
892
References
92
Citations by year
2026: 14 · 2025: 13 · 2024: 22 · 2023: 20 · 2022: 24 · 2021: 33 · 2020: 40 · 2019: 45 · 2018: 57 · 2017: 56 · 2016: 57 · 2015: 55 · 2014: 71 · 2013: 88 · 2012: 83
FWCI
46.90
Type
journal article
Language
en
Open access
Locations
  • Advanced Drug Delivery Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders
  • National Institutes of Health (5u54ca119349-05)
  • National Heart, Lung, and Blood Institute (U01HL080731)
  • National Cancer Institute (U54CA126515, U54 CA-119349)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords
magnetic nanoparticles, targeted imaging, theranostics, MRI contrast agents, affinity ligands, phage display, aptamers, immunoglobulins, tumor imaging, atherosclerosis, diabetes mellitus, multifunctional nanomaterials
MeSH terms
Animals, Biocompatible Materials, Diagnostic Imaging, Ferric Compounds, Humans, Magnetics, Neoplasms, Drug Delivery Systems, Atherosclerosis, Nanoparticles

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