Multifunctional magnetic nanoparticles for targeted imaging and therapy
Open accessAbstract
Magnetic nanoparticles have become important tools for the imaging of prevalent diseases, such as cancer, atherosclerosis, diabetes, and others. While first generation nanoparticles were fairly nonspecific, newer generations have been targeted to specific cell types and molecular targets via affinity ligands. Commonly, these ligands emerge from phage or small molecule screens, or are based on antibodies or aptamers. Secondary reporters and combined therapeutic molecules have further opened potential clinical applications of these materials. This review summarizes some of the recent biomedical applications of these newer magnetic nanomaterials.
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Upon surface modification, superparamagnetic iron oxide nanoparticles (SPION) can be employed for magnetic resonance imaging, magnetic particle imaging, targeted delivery of drugs, proteins, antibodies and nucleic acids, hyperthermia, biosensing, tissue repair, and separation of biomolecules.
“Upon surface-modification, the resulting superparamagnetic iron oxide nanoparticles (SPION) can be employed for magnetic resonance imaging (MRI) [4–8], magnetic particle imaging (MPI) [9–12], targeted delivery of drugs, proteins, antibodies, and nucleic acids [6, 7, 13, 14], hyperthermia [15–17], biosensing [18], tissue repair [19], and separation of biomolecules [20].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [7]
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- Authors
- MCCARTHY, J., & WEISSLEDER, R.
- Affiliations
- Harvard University (US)
- Corresponding author
- MCCARTHY, J
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2008-08-17
- Volume
- 60
- Issue
- 11
- Pages
- 1241-1251
- ISSN
- 0169-409X (ISSN-L)
- PMC
- PMC2583936
- OpenAlex
- W2154964751
- Cited by
- 892
- References
- 92
- Citations by year
- 2026: 14 · 2025: 13 · 2024: 22 · 2023: 20 · 2022: 24 · 2021: 33 · 2020: 40 · 2019: 45 · 2018: 57 · 2017: 56 · 2016: 57 · 2015: 55 · 2014: 71 · 2013: 88 · 2012: 83
- FWCI
- 46.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Institutes of Health (5u54ca119349-05)
- National Heart, Lung, and Blood Institute (U01HL080731)
- National Cancer Institute (U54CA126515, U54 CA-119349)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- magnetic nanoparticles, targeted imaging, theranostics, MRI contrast agents, affinity ligands, phage display, aptamers, immunoglobulins, tumor imaging, atherosclerosis, diabetes mellitus, multifunctional nanomaterials
- MeSH terms
- Animals, Biocompatible Materials, Diagnostic Imaging, Ferric Compounds, Humans, Magnetics, Neoplasms, Drug Delivery Systems, Atherosclerosis, Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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