The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Terpene Biosynthesis: Modularity Rules
Open accessAbstract
Terpenes are the largest class of small‐molecule natural products on earth, and the most abundant by mass. Here, we summarize recent developments in elucidating the structure and function of the proteins involved in their biosynthesis. There are six main building blocks or modules (α, β, γ, δ, ε, and ζ) that make up the structures of these enzymes: the αα and αδ head‐to‐tail trans‐prenyl transferases that produce trans‐isoprenoid diphosphates from C 5 precursors; the ε head‐to‐head prenyl transferases that convert these diphosphates into the tri‐ and tetraterpene precursors of sterols, hopanoids, and carotenoids; the βγ di‐ and triterpene synthases; the ζ head‐to‐tail cis‐prenyl transferases that produce the cis‐isoprenoid diphosphates involved in bacterial cell wall biosynthesis; and finally the α, αβ, and αβγ terpene synthases that produce plant terpenes, with many of these modular enzymes having originated from ancestral α and β domain proteins. We also review progress in determining the structure and function of the two 4Fe‐4S reductases involved in formation of the C 5 diphosphates in many bacteria, where again, highly modular structures are found.
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Cited by
Masyita, A., Mustika Sari, R., Dwi Astuti, A., Yasir, B., Rahma Rumata, N., Emran, T. B., Nainu, F., & Simal-Gandara, J. (2022) · Food Chemistry: X · doi:10.1016/j.fochx.2022.100217 · Cited by 1,052
Review on plant antimicrobials: a mechanistic viewpoint
Khameneh, B., Iranshahy, M., Soheili, V., & Fazly Bazzaz, B. S. (2019) · Antimicrobial Resistance & Infection Control · doi:10.1186/s13756-019-0559-6 · Cited by 891
Triterpene Biosynthesis in Plants
Thimmappa, R., Geisler, K., Louveau, T., O'Maille, P., & Osbourn, A. (2014) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-050312-120229 · Cited by 803
Functions, Therapeutic Applications, and Synthesis of Retinoids and Carotenoids
Álvarez, R., Vaz, B., Gronemeyer, H., & de Lera, Á. R. (2014) · Chemical Reviews · doi:10.1021/cr400126u · Cited by 260
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Berthelot, K., Estevez, Y., Deffieux, A., & Peruch, F. (2012) · Biochimie · doi:10.1016/j.biochi.2012.03.021 · Cited by 180
Metadata
- Authors
- Oldfield, E., & Lin, F.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2011-11-21
- Volume
- 51
- Issue
- 5
- Pages
- 1124-1137
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2148532595
- Cited by
- 391
- References
- 72
- FWCI
- 7.05
- Type
- journal article
- Language
- en
- Open access
- green
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