The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Continuous‐Flow Synthesis of the Anti‐Malaria Drug Artemisinin
Abstract
Malaria is a serious global health issue. Artemisinin combination treatments are the first-line drugs, but supplies are limited because artemisinin is obtained solely by extraction from Artemisia annua. A continuous-flow process that converts dihydroartemisinic acid into artemisinin (see scheme) was shown to be an inexpensive and scalable process that can ensure a steady, affordable supply of artemisinin.
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Citations
Cites
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
Ro, D.-K., Paradise, E. M., Ouellet, M., Fisher, K. J., Newman, K. L., Ndungu, J. M., Ho, K. A., Eachus, R. A., Ham, T. S., Kirby, J., et al. (2006) · Nature · doi:10.1038/nature04640 · Cited by 2,805
Physical Mechanisms of Generation and Deactivation of Singlet Oxygen
Schweitzer, C., & Schmidt, R. (2003) · Chemical Reviews · doi:10.1021/cr010371d · Cited by 2,123
Photochemical Reactions as Key Steps in Organic Synthesis
Hoffmann, N. (2008) · Chemical Reviews · doi:10.1021/cr0680336 · Cited by 1,445
Deciding Whether To Go with the Flow: Evaluating the Merits of Flow Reactors for Synthesis
Hartman, R. L., McMullen, J. P., & Jensen, K. F. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201004637 · Cited by 999
Qinghaosu (Artemisinin): The Price of Success
White, N. J. (2008) · Science · doi:10.1126/science.1155165 · Cited by 954
Microreactors: New Technology for Modern Chemistry
Ehrfeld, W., Hessel, V., & Löwe, H. (2000) · Wiley eBooks · doi:10.1002/3527601953 · Cited by 778
Ten key issues in modern flow chemistry
Wegner, J., Ceylan, S., & Kirschning, A. (2011) · Chemical Communications · doi:10.1039/c0cc05060a · Cited by 641
A Practical Flow Reactor for Continuous Organic Photochemistry
Hook, B. D. A., Dohle, W., Hirst, P. R., Pickworth, M., Berry, M. B., & Booker-Milburn, K. I. (2005) · The Journal of Organic Chemistry · doi:10.1021/jo050705p · Cited by 381
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Cited by
High-level semi-synthetic production of the potent antimalarial artemisinin
Paddon, C. J., Westfall, P. J., Pitera, D. J., Benjamin, K., Fisher, K., McPhee, D., Leavell, M. D., Tai, A., Main, A., Eng, D., et al. (2013) · Nature · doi:10.1038/nature12051 · Cited by 2,060
The Hitchhiker’s Guide to Flow Chemistry
Plutschack, M. B., Pieber, B., Gilmore, K., & Seeberger, P. H. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00183 · Cited by 1,995
Self-citationCambié, D., Bottecchia, C., Straathof, N. J. W., Hessel, V., & Noël, T. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00707 · Cited by 1,502
Using Singlet Oxygen to Synthesize Natural Products and Drugs
Ghogare, A. A., & Greer, A. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00726 · Cited by 719
Flow chemistry syntheses of natural products
Pastre, J. C., Browne, D. L., & Ley, S. V. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60246j · Cited by 658
Metadata
- Authors
- Lévesque, F., & Seeberger, P. H.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2012-01-16
- Volume
- 51
- Issue
- 7
- Pages
- 1706-1709
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2035045727
- Cited by
- 516
- References
- 20
- FWCI
- 34.70
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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