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Significantly Improved Analytical Sensitivity of Lateral Flow Immunoassays by Using Thermal Contrast
Open accessAbstract
Heat beyond visual: The thermal contrast from the heating of gold nanoparticles upon laser stimulation can improve the analytical sensitivity of lateral flow assays (LFAs; see picture). A 32-fold improvement in sensitivity of an approved LFA for cryptococcal antigen (purple diamond) was shown, with the potential for further improvement by optimizing the backing material and the properties of the antibody-coated nanoparticles (red circle with blue Y).
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Cited by
Diverse Applications of Nanomedicine
Pelaz, B., Alexiou, C., Alvarez-Puebla, R. A., Alves, F., Andrews, A. M., Ashraf, S., Balogh, L. P., Ballerini, L., Bestetti, A., Brendel, C., et al. (2017) · ACS Nano · doi:10.1021/acsnano.6b06040 · Cited by 1,350
Self-citationUltrasensitive and Highly Specific Lateral Flow Assays for Point-of-Care Diagnosis
Liu, Y., Zhan, L., Qin, Z., Sackrison, J., & Bischof, J. C. (2021) · ACS Nano · doi:10.1021/acsnano.0c10035 · Cited by 626
Self-citationDissecting the Molecular Mechanism of Apoptosis during Photothermal Therapy Using Gold Nanoprisms
Pérez-Hernández, M., del Pino, P., Mitchell, S. G., Moros, M., Stepien, G., Pelaz, B., Parak, W. J., Gálvez, E. M., Pardo, J., & de la Fuente, J. M. (2015) · ACS Nano · doi:10.1021/nn505468v · Cited by 398
Zangheri, M., Cevenini, L., Anfossi, L., Baggiani, C., Simoni, P., Di Nardo, F., & Roda, A. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2014.08.048 · Cited by 373
Metadata
- Authors
- Qin, Z., Chan, W. C. W., Boulware, D. R., Akkin, T., Butler, E. K., & Bischof, J. C.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2012-03-23
- Volume
- 51
- Issue
- 18
- Pages
- 4358-4361
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2159861516
- Cited by
- 221
- References
- 0
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- green
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- Qin, Z., Chan, W. C. W., Boulware, D. R., Akkin, T., Butler, E. K., & Bischof, J. C. (2012). Significantly Improved Analytical Sensitivity of Lateral Flow Immunoassays by Using Thermal Contrast. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201200997
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
