Unraveling hot spots in binding interfaces: progress and challenges

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Dissection of a Nuclear Localization Signal

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An Analysis of the Interactions between the Sem−5 SH3 Domain and Its Ligands Using Molecular Dynamics, Free Energy Calculations, and Sequence Analysis

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Energetic Determinants of Internal Motif Recognition by PDZ Domains

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Protein functional epitopes: hot spots, dynamics and combinatorial libraries

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Evidence that a protein‐protein interaction ‘hot spot’ on heterotrimeric G protein βγ subunits is used for recognition of a subclass of effectors

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The peroxisomal membrane protein Pex13p shows a novel mode of SH3 interaction

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Improved Scoring of Ligand−Protein Interactions Using OWFEG Free Energy Grids

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Similarity-driven flexible ligand docking

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Protein structural alignments and functional genomics

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Improving the performance of rosetta using multiple sequence alignment information and global measures of hydrophobic core formation

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Computer simulations of protein folding by targeted molecular dynamics

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Functional Significance of the β-Hairpin in the Insecticidal Neurotoxin ω-Atracotoxin-Hv1a

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Lysine 322 in the human IgG3 CH2 domain is crucial for antibody dependent complement activation

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Single Amino Acid Substitutions in κ-Conotoxin PVIIA Disrupt Interaction with the Shaker K+ Channel

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Identification of the ligand-binding site of the BMP type IA receptor for BMP-4

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Analysis of the interactions of human ribonuclease inhibitor with angiogenin and ribonuclease A by mutagenesis: importance of inhibitor residues inside versus outside the C-terminal “hot spot” 1 1Edited by J. Wells

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A Novel Family of Hairpin Peptides That Inhibit IgE Activity by Binding to the High-Affinity IgE Receptor

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Epitope mapping for four monoclonal antibodies against human plasminogen activator inhibitor type‐1

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Fast Transient Cytokine–Receptor Interactions Monitored in Real Time by Reflectometric Interference Spectroscopy

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May the driving force be with you--whatever it is.

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Scanning Mutagenesis Identifies Amino Acid Side Chains in Transmembrane Domain 5 of the M1Muscarinic Receptor that Participate in Binding the Acetyl Methyl Group of Acetylcholine

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Structure−Function Analysis of a Phage Display-Derived Peptide That Binds to Insulin-like Growth Factor Binding Protein 1

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N-terminal Residues of Plasmatocyte-spreading Peptide Possess Specific Determinants Required for Biological Activity

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Evaluation of protein–protein association energies by free energy perturbation calculations

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Theoretical Studies Suggest a New Antifolate as a More Potent Inhibitor of Thymidylate Synthase

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Structural consequences of an amino acid deletion in the B1 domain of protein G

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Alanine Scanning Mutants of Rat Proinsulin I Show Functional Diversity of Anti-Insulin Monoclonal Antibodies

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Crystal structure of tropomyosin at 7 �ngstroms resolution

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Small-molecule inhibitors of protein–protein interactions: progressing towards the dream

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Hot spots—A review of the protein–protein interface determinant amino‐acid residues

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Protein–protein interactions: Structurally conserved residues distinguish between binding sites and exposed protein surfaces

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Hot Regions in Protein–Protein Interactions: The Organization and Contribution of Structurally Conserved Hot Spot Residues

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Tethering: Fragment-Based Drug Discovery

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Binding MOAD (Mother Of All Databases)

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Protein–protein interactions as targets for small-molecule therapeutics in cancer

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iSEE: Interface structure, evolution, and energy-based machine learning predictor of binding affinity changes upon mutations

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Prism: Protein-Protein Interaction Prediction by Structural Matching

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Targeting protein–protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?

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Comprehensive Experimental and Computational Analysis of Binding Energy Hot Spots at the NF-κB Essential Modulator/IKKβ Protein–Protein Interface

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Evidence of Conformational Selection Driving the Formation of Ligand Binding Sites in Protein-Protein Interfaces

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Total Mutagenesis and the Effects on the MDM2‐p53 Interaction

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High-Throughput Scanning Mutagenesis by Recombination Polymerase Chain Reaction

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Unravelling Hot Spots: a comprehensive computational mutagenesis study

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