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Enantioselective Intramolecular CH Amination Catalyzed by Engineered Cytochrome P450 Enzymes In Vitro and In Vivo
Open accessAbstract
Nitrogen activation: Though P450 enzymes are masters of oxygen activation and insertion into CH bonds, their ability to use nitrogen for the same purpose has so far not been explored. Engineered variants of cytochrome P450BM3 have now been found to catalyze intramolecular CH aminations in azide substrates. Mutations to two highly conserved residues significantly increased this activity.
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Cited by
Opportunities for merging chemical and biological synthesis
Wallace, S., & Balskus, E. P. (2014) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2014.03.006 · Cited by 86
“H bonds and to develop a C-H amination reaction using sulfonyl azide substrates [41•,42].”
A high-throughput biocatalytic platform for screening isomeric kainoid natural products
Shepherd, R. A., Ramachandra, M., Hopiavuori, A. R., Jones, M. C., Fihn, C. A., Tabag, A. J., Manjunath, A., Gad, L. Y., Whipple, C. R., McKinnie, S. M. K., et al. (2026) · Cell Reports Physical Science · doi:10.1016/j.xcrp.2025.103092 · Cited by 2
Metadata
- Authors
- McIntosh, J. A., Coelho, P. S., Farwell, C. C., Wang, Z. J., Lewis, J. C., Brown, T. R., & Arnold, F. H.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2013-07-24
- Volume
- 52
- Issue
- 35
- Pages
- 9309-9312
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2165365513
- Cited by
- 300
- References
- 0
- FWCI
- 11.03
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Enantioselective Intramolecular CH Amination Catalyzed by Engineered Cytochrome P450 Enzymes In Vitro and In Vivo. https://app.cochat.ai/papers/10.1002/anie.201304401
- The paper
- McIntosh, J. A., Coelho, P. S., Farwell, C. C., Wang, Z. J., Lewis, J. C., Brown, T. R., & Arnold, F. H. (2013). Enantioselective Intramolecular CH Amination Catalyzed by Engineered Cytochrome P450 Enzymes In Vitro and In Vivo. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201304401
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