Opportunities for merging chemical and biological synthesis

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

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Engineering the third wave of biocatalysis

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High-level semi-synthetic production of the potent antimalarial artemisinin

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Functional Molecular Flasks: New Properties and Reactions within Discrete, Self‐Assembled Hosts

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Enzyme promiscuity: A mechanistic and evolutionary perspective

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Discovery of an α-Amino C–H Arylation Reaction Using the Strategy of Accelerated Serendipity

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Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes

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Manufacturing Molecules Through Metabolic Engineering

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Biotinylated Rh(III) Complexes in Engineered Streptavidin for Accelerated Asymmetric C–H Activation

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Enzyme Mimics Based Upon Supramolecular Coordination Chemistry

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Finding the Right (Bioorthogonal) Chemistry

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Enzyme promiscuity: evolutionary and mechanistic aspects

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Greene's protective groups in organic synthesis

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Bioorthogonal Reactions for Labeling Proteins

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Conversion of a protein to a homogeneous asymmetric hydrogenation catalyst by site-specific modification with a diphosphinerhodium(I) moiety

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Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host

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A supramolecular approach to combining enzymatic and transition metal catalysis

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Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host. 1984.

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A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo

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"Artificial enzyme" combining a metal catalytic group and a hydrophobic binding cavity

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Synthetic cascades are enabled by combining biocatalysts with artificial metalloenzymes

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Artificial Metalloenzymes Based on the Biotin−Avidin Technology: Enantioselective Catalysis and Beyond

Ward, T. R. (2010) · Accounts of Chemical Research · doi:10.1021/ar100099u · Cited by 324 · see citing works

Enantioselective Intramolecular CH Amination Catalyzed by Engineered Cytochrome P450 Enzymes In Vitro and In Vivo

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Dynamic kinetic resolution catalyzed by enzymes and metals

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A Decade of Bioorthogonal Chemistry

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The primary signal in the biological perception of temperature: Pd-catalyzed hydrogenation of membrane lipids stimulated the expression of the desA gene in Synechocystis PCC6803.

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A Simple, Multidimensional Approach to High-Throughput Discovery of Catalytic Reactions

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Artificial Metalloenzymes and Metallopeptide Catalysts for Organic Synthesis

Lewis, J. C. (2013) · ACS Catalysis · doi:10.1021/cs400806a · Cited by 270 · see citing works

Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance

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Dynamic kinetic resolution with enzyme and palladium combinations

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Cytochrome P450-catalyzed insertion of carbenoids into N–H bonds

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Dynamic kinetic resolutions and asymmetric transformations by enzymes coupled with metal catalysis

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Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase

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Synthetic Biology and Metabolic Engineering Approaches To Produce Biofuels

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De novo biosynthetic pathways: rational design of microbial chemical factories

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Cooperative Tandem Catalysis by an Organometallic Complex and a Metalloenzyme

Denard, C. A., Huang, H., Bartlett, M. J., Lu, L., Tan, Y., Zhao, H., & Hartwig, J. F. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201305778 · Cited by 145 · see citing works

Organic synthesis toward small-molecule probes and drugs

Schreiber, S. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103205108 · Cited by 138 · see citing works

Biocatalyst development by directed evolution

Wang, M., Si, T., & Zhao, H. (2012) · Bioresource Technology · doi:10.1016/j.biortech.2012.01.054 · Cited by 136 · see citing works

Advances in metabolic pathway and strain engineering paving the way for sustainable production of chemical building blocks

Chen, Y., & Nielsen, J. (2013) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2013.03.008 · Cited by 125 · see citing works

Bioinorganic and medicinal chemistry: aspects of gold(i)-protein complexes

Bhabak, K. P., Bhuyan, B. J., & Mugesh, G. (2011) · Dalton Transactions · doi:10.1039/c0dt01057j · Cited by 124 · see citing works

On the nature of mutual inactivation between [Cp*Rh(bpy)(H2O)]2+ and enzymes – analysis and potential remedies

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Chemical synthesis using synthetic biology

Carothers, J. M., Goler, J. A., & Keasling, J. D. (2009) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2009.08.001 · Cited by 104 · see citing works

A Dual Anchoring Strategy for the Localization and Activation of Artificial Metalloenzymes Based on the Biotin–Streptavidin Technology

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A constructive debate

Keasling, J. D., Mendoza, A., & Baran, P. S. (2012) · Nature · doi:10.1038/492188a · Cited by 92 · see citing works

Human carbonic anhydrase II as host protein for the creation of artificial metalloenzymes: the asymmetric transfer hydrogenation of imines

Monnard, F. W., Nogueira, E. S., Heinisch, T., Schirmer, T., & Ward, T. R. (2013) · Chemical Science · doi:10.1039/c3sc51065d · Cited by 81 · see citing works

Demonstration of Imino Acids as Products of the Reactions Catalyzed by D- and L-Amino Acid Oxidases

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Genetic Optimization of the Catalytic Efficiency of Artificial Imine Reductases Based on Biotin–Streptavidin Technology

Schwizer, F., Köhler, V., Dürrenberger, M., Knörr, L., & Ward, T. R. (2013) · ACS Catalysis · doi:10.1021/cs400428r · Cited by 57 · see citing works

Flexibility and Reactivity in Promiscuous Enzymes

Gatti‐Lafranconi, P., & Hollfelder, F. (2013) · ChemBioChem · doi:10.1002/cbic.201200628 · Cited by 48 · see citing works

The Emergence of the Structure of the Molecule and the Art of Its Synthesis

Nicolaou, K. C. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201207081 · Cited by 43 · see citing works

Rescuing Auxotrophic Microorganisms with Nonenzymatic Chemistry

Lee, Y., Umeano, A. C., & Balskus, E. P. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201307033 · Cited by 36 · see citing works

Systems Metabolic Engineering

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Simultaneous butyrate oxidation by Syntrophomonas wolfei and catalytic olefin reduction in absence of interspecies hydrogen transfer

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Systems Metabolic Engineering of Escherichia coli for Chemicals, Materials, Biofuels, and Pharmaceuticals

Na, D., Park, J. H., Jang, Y., Lee, J. W., & Lee, S. Y. (2012) · Springer eBooks · doi:10.1007/978-94-007-4534-6_5 · Cited by 8 · see citing works

Role of Biocatalysis in Sustainable Chemistry

Sheldon, R. A., & Woodley, J. M. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00203 · Cited by 1,783 · see citing works

Artificial Metalloenzymes: Reaction Scope and Optimization Strategies

Schwizer, F., Okamoto, Y., Heinisch, T., Gu, Y., Pellizzoni, M. M., Lebrun, V., Reuter, R., Köhler, V., Lewis, J. C., & Ward, T. R. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00014 · Cited by 836 · see citing works

Artificial Biocatalytic Linear Cascades for Preparation of Organic Molecules

Schrittwieser, J. H., Velikogne, S., Hall, M., & Kroutil, W. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00033 · Cited by 637 · see citing works

Multienzyme Cascade Reactions—Status and Recent Advances

Sperl, J., & Sieber, V. (2018) · ACS Catalysis · doi:10.1021/acscatal.7b03440 · Cited by 367 · see citing works

Systems protobiology: origin of life in lipid catalytic networks

Lancet, D., Zidovetzki, R., & Markovitch, O. (2018) · Journal of The Royal Society Interface · doi:10.1098/rsif.2018.0159 · Cited by 182 · see citing works

Biological and related applications of pillar[n]arenes

Sathiyajith, C., Shaikh, R. R., Han, Q., Zhang, Y., Meguellati, K., & Yang, Y. (2016) · Chemical Communications · doi:10.1039/c6cc08967d · Cited by 177 · see citing works

Where Chemocatalysis Meets Biocatalysis: In Water

Gröger, H., Gallou, F., & Lipshutz, B. H. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00416 · Cited by 177 · see citing works

Improving formaldehyde consumption drives methanol assimilation in engineered E. coli

Woolston, B. M., King, J. R., Reiter, M., Hove, B. V., & Stephanopoulos, G. N. (2018) · Nature Communications · doi:10.1038/s41467-018-04795-4 · Cited by 129 · see citing works

Microbial Production of Short Chain Fatty Acids from Lignocellulosic Biomass: Current Processes and Market

Baumann, I., & Westermann, P. (2016) · BioMed Research International · doi:10.1155/2016/8469357 · Cited by 122 · see citing works

Artificial concurrent catalytic processes involving enzymes

Köhler, V., & Turner, N. J. (2014) · Chemical Communications · doi:10.1039/c4cc07277d · Cited by 114 · see citing works

“Close-to-Release”: Spontaneous Bioorthogonal Uncaging Resulting from Ring-Closing Metathesis

Sabatino, V., Rebelein, J. G., & Ward, T. R. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b07193 · Cited by 95 · see citing works

Valorization of Biodiesel Byproduct Crude Glycerol for the Production of Bioenergy and Biochemicals

Kosamia, N. M., Samavi, M., Uprety, B. K., & Rakshit, S. K. (2020) · Catalysts · doi:10.3390/catal10060609 · Cited by 86 · see citing works

Interfacing Microbial Styrene Production with a Biocompatible Cyclopropanation Reaction

Wallace, S., & Balskus, E. P. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201502185 · Cited by 85 · see citing works

Enzyme engineering in the context of novel pathways and products

Otte, K. B., & Hauer, B. (2015) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2014.12.011 · Cited by 77 · see citing works

Metallopeptide catalysts and artificial metalloenzymes containing unnatural amino acids

Lewis, J. C. (2014) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2014.12.016 · Cited by 73 · see citing works

Alkaloids in Contemporary Drug Discovery to Meet Global Disease Needs

Daley, S.-K., & Cordell, G. A. (2021) · Molecules · doi:10.3390/molecules26133800 · Cited by 76 · see citing works

Development of a One-Pot Tandem Reaction Combining Ruthenium-Catalyzed Alkene Metathesis and Enantioselective Enzymatic Oxidation To Produce Aryl Epoxides

Denard, C. A., Bartlett, M. J., Wang, Y., Lu, L., Hartwig, J. F., & Zhao, H. (2015) · ACS Catalysis · doi:10.1021/acscatal.5b00533 · Cited by 71 · see citing works

Receptor-Based Artificial Metalloenzymes on Living Human Cells

Ghattas, W., Dubosclard, V., Wick, A., Bendelac, A., Guillot, R., Ricoux, R., & Mahy, J. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b04326 · Cited by 70 · see citing works

Designer Micelles Accelerate Flux Through Engineered Metabolism in E. coli and Support Biocompatible Chemistry

Wallace, S., & Balskus, E. P. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201600966 · Cited by 69 · see citing works

Design and Engineering of Metal Catalysts for Bio-orthogonal Catalysis in Living Systems

Liu, Y., & Bai, Y. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c00581 · Cited by 66 · see citing works

Highly thermostable carboxylic acid reductases generated by ancestral sequence reconstruction

Thomas, A., Cutlan, R., Finnigan, W., van der Giezen, M., & Harmer, N. J. (2019) · Communications Biology · doi:10.1038/s42003-019-0677-y · Cited by 58 · see citing works

Chemoenzymatic conversion of amides to enantioenriched alcohols in aqueous medium

Dander, J. E., Giroud, M., Racine, S., Darzi, E. R., Alvizo, O., Entwistle, D. A., & Garg, N. K. (2019) · Communications Chemistry · doi:10.1038/s42004-019-0182-8 · Cited by 56 · see citing works

Organic reactions in aqueous media catalyzed by nickel

Satpute, D. P., Vaidya, G. N., Lokhande, S. K., Shinde, S. D., Bhujbal, S. M., Chatterjee, D. R., Rana, P., Venkatesh, A., Nagpure, M., & Kumar, D. (2021) · Green Chemistry · doi:10.1039/d1gc01983j · Cited by 51 · see citing works

Accessing Nature’s diversity through metabolic engineering and synthetic biology

King, J. R., Edgar, S., Qiao, K., & Stephanopoulos, G. N. (2016) · F1000Research · doi:10.12688/f1000research.7311.1 · Cited by 49 · see citing works

Fixing the Unfixable: The Art of Optimizing Natural Products for Human Medicine

Yñigez‐Gutierrez, A. E., & Bachmann, B. O. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b00246 · Cited by 48 · see citing works

Chemo-enzymatic synthesis of 11-hydroxyundecanoic acid and 1,11-undecanedioic acid from ricinoleic acid

Jang, H., Singha, K., Kim, H.-H., Kwon, Y.-U., & Park, J. (2015) · Green Chemistry · doi:10.1039/c5gc01017a · Cited by 46 · see citing works

Chemo-enzymatic Total Syntheses of Jorunnamycin A, Saframycin A, and N-Fmoc Saframycin Y3

Tanifuji, R., Koketsu, K., Takakura, M., Asano, R., Minami, A., Oikawa, H., & Oguri, H. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b07161 · Cited by 45 · see citing works

Enceladus: First Observed Primordial Soup Could Arbitrate Origin-of-Life Debate

Kahana, A., Schmitt-Kopplin, P., & Lancet, D. (2019) · Astrobiology · doi:10.1089/ast.2019.2029 · Cited by 40 · see citing works

Orthogonal Assays Clarify the Oxidative Biochemistry of Taxol P450 CYP725A4

Biggs, B. W., Rouck, J. E., Kambalyal, A., Arnold, W. R., Lim, C. G., Mey, M. D., O’Neil-Johnson, M., Starks, C. M., Das, A., & Ajikumar, P. K. (2016) · ACS Chemical Biology · doi:10.1021/acschembio.5b00968 · Cited by 39 · see citing works

Selective Light-Driven Chemoenzymatic Trifluoromethylation/Hydroxylation of Substituted Arenes

Alfaro, V. S., Melkie, M. A., Sulca, C., Li, J., Tang, L., Li, J., Faris, J., Foley, B., Banh, T., Kato, M., et al. (2018) · ACS Catalysis · doi:10.1021/acscatal.7b04160 · Cited by 39 · see citing works

A biocompatible Lossen rearrangement in Escherichia coli

Johnson, N. W., Ortega, M. V., Thorpe, T. W., Era, Y., Kjeldsen, A., Mulholland, K. R., & Wallace, S. (2025) · Nature Chemistry · doi:10.1038/s41557-025-01845-5 · Cited by 38 · see citing works

Metal-Catalyzed Intra- and Intermolecular Addition of Carboxylic Acids to Alkynes in Aqueous Media: A Review

Francos, J., & Cadierno, V. (2017) · Catalysts · doi:10.3390/catal7110328 · Cited by 37 · see citing works

Status check: biocatalysis; its use with and without chemocatalysis. How does the fine chemicals industry view this area?

Gallou, F., Gröger, H., & Lipshutz, B. H. (2023) · Green Chemistry · doi:10.1039/d3gc01931d · Cited by 36 · see citing works

Using non-enzymatic chemistry to influence microbial metabolism

Wallace, S., Schultz, E. E., & Balskus, E. P. (2015) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2014.12.024 · Cited by 31 · see citing works

Twenty Years of “Lipid World”: A Fertile Partnership with David Deamer

Lancet, D., Segrè, D., & Kahana, A. (2019) · Life · doi:10.3390/life9040077 · Cited by 30 · see citing works

Interfacing Microbial Styrene Production with a Biocompatible Cyclopropanation Reaction

Wallace, S., & Balskus, E. P. (2015) · Angewandte Chemie · doi:10.1002/ange.201502185 · Cited by 28 · see citing works

Interfacing non-enzymatic catalysis with living microorganisms

Sadler, J. C., Dennis, J. A., Johnson, N. W., & Wallace, S. (2021) · RSC Chemical Biology · doi:10.1039/d1cb00072a · Cited by 27 · see citing works

Integrating biocompatible chemistry and manipulating cofactor partitioning in metabolically engineered Lactococcus lactis for fermentative production of (3S)‐acetoin

Liu, J., Solem, C., & Jensen, P. R. (2016) · Biotechnology and Bioengineering · doi:10.1002/bit.26038 · Cited by 27 · see citing works

Recent Approaches in the Production of Novel Enzymes From Environmental Samples by Enrichment Culture and Metagenomic Approach

Madhuri, R. J., Saraswathi, M., Gowthami, K., Bhargavi, M., Divya, Y., & Deepika, V. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-816328-3.00019-2 · Cited by 27 · see citing works

Designer Micelles Accelerate Flux Through Engineered Metabolism in E. coli and Support Biocompatible Chemistry

Wallace, S., & Balskus, E. P. (2016) · Angewandte Chemie · doi:10.1002/ange.201600966 · Cited by 23 · see citing works

Merger of Whole Cell Biocatalysis with Organocatalysis Upgrades Alcohol Feedstocks in a Mild, Aqueous, One-Pot Process

Stewart, K. N., Hicks, E. G., & Domaille, D. W. (2020) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.9b06663 · Cited by 22 · see citing works

Palladium in biological media: Can the synthetic chemist's most versatile transition metal become a powerful biological tool?

Brewster, R. C., Klemencic, E., & Jarvis, A. G. (2020) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2020.111317 · Cited by 22 · see citing works

Concatenating Microbial, Enzymatic, and Organometallic Catalysis for Integrated Conversion of Renewable Carbon Sources

Klos, N., Osterthun, O., Mengers, H. G., Lanzerath, P., von Westarp, W. G., Lim, G., Gausmann, M., Spöring, J., Wiesenthal, J., Guntermann, N., et al. (2024) · JACS Au · doi:10.1021/jacsau.4c00511 · Cited by 21 · see citing works

Algal metabolites: Paving the way towards new generation antidiabetic therapeutics

Kaushik, A., Sangtani, R., Parmar, H. S., & Bala, K. (2022) · Algal Research · doi:10.1016/j.algal.2022.102904 · Cited by 20 · see citing works

Transition Metal‐Free Reduction of Activated Alkenes Using a Living Microorganism

Brewster, R. C., Suitor, J. T., Bennett, A. W., & Wallace, S. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201903973 · Cited by 18 · see citing works

Integrative electrochemical and biological catalysis for the mild and efficient utilization of renewable electricity and carbon resources

Liu, L., & Pant, D. (2023) · Sustainable Energy & Fuels · doi:10.1039/d3se00876b · Cited by 18 · see citing works

Attractor dynamics drives self-reproduction in protobiological catalytic networks

Kahana, A., Segev, L., & Lancet, D. (2023) · Cell Reports Physical Science · doi:10.1016/j.xcrp.2023.101384 · Cited by 18 · see citing works

Artificial Biocatalytic Linear Cascades to Access Hydroxy Acids, Lactones, and α- and β-Amino Acids

Schrittwieser, J. H., Velikogne, S., & Kroutil, W. (2018) · Catalysts · doi:10.3390/catal8050205 · Cited by 16 · see citing works

Rewriting the Metabolic Blueprint: Advances in Pathway Diversification in Microorganisms

Hossain, G. S., Nadarajan, S. P., Zhang, L., Ng, T.-K., Foo, J. L., Ling, H., Choi, W. J., & Chang, M. W. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00155 · Cited by 15 · see citing works

Robust and Versatile Host Protein for the Design and Evaluation of Artificial Metal Centers

Fischer, J., Renn, D., Quitterer, F., Radhakrishnan, A., Liu, M., Makki, A. A., Ghorpade, S. A., Rueping, M., Arold, S. T., Groll, M., et al. (2019) · ACS Catalysis · doi:10.1021/acscatal.9b02896 · Cited by 14 · see citing works

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Introduction of Nanotechnology and Sustainability

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Merging of a chemical reaction with microbial metabolism via inverse phase transfer catalysis for efficient production of red Monascus pigments

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The Bipartisan Future of Synthetic Chemistry and Synthetic Biology

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Chemical bio-manufacture from diverse C-rich waste polymeric feedstocks using engineered microorganisms

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Three Sides of the Same Coin: Combining Microbial, Enzymatic, and Organometallic Catalysis for Integrated Conversion of Renewable Carbon Sources

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Tyramine Derivatives Catalyze the Aldol Dimerization of Butyraldehyde in the Presence of Escherichia coli

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Transition Metal‐Free Reduction of Activated Alkenes Using a Living Microorganism

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Biocompatible α‐Methylenation of Metabolic Butyraldehyde in Living Bacteria

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New-to-nature biocompatible chemistry for plastic waste upcycling

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Interfacing Whole Cell Biocatalysis with a Biocompatible Pictet‐Spengler Reaction for One‐Pot Syntheses of Tetrahydroisoquinolines and Tryptolines**

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Homogeneous Catalysis and Mechanisms in Water and Biphasic Media

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Role of Enzymes in Synthesis of Biologically Important Organic Scaffolds

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mTFP* closed conformation: I197E-Y200H-Y204H mutant for enhanced metal binding

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Regioselective Palmitoylation of 9-(2,3-Dihydroxy- propyl)adenine Catalyzed by a Glycopolymer-enzyme Conjugate

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TridentSynth: a webtool for the retrosynthesis of molecules using chimeric type I polyketide synthases and chemoenzymatic pathways

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Biocompatible α‐Methylenation of Metabolic Butyraldehyde in Living Bacteria

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Synthetic Biology Strategies for Polyhydroxyalkanoate Synthesis

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Nucleic Acid Based Nanoconstructs for Environmental Analysis in Atypical Contexts

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Protobiotic Network Reproducers Are Compositional Attractors: Enhanced Probability for Life's OriginPreprint

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Interfacing Biocompatible Reactions with Engineered Escherichia coli

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Tandem Biocatalysis Unlocks the Challenging de Novo Production of Plant Natural Products

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Processing Catalytic Information in Bacteria

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In Silico Exploration of Metabolite-Derived Soft Materials Using a Chemical Reaction Network

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Metabolic fingerprinting of photosynthetic carbon-fixing algae: Revealing efficient solvent-based approach for biopharmaceutical discovery

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Synthesis, In Silico Evaluation of ADME/T Properties, as well as Antioxidant, Antibacterial, Anti‐Inflammatory, and Anticancer Activities of Methyl(2‐(Phenylethynyl)Phenyl)Sulfane

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Routes to Production of Plant Natural Products for Use as Active Ingredients in Bioinsecticides

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Opportunities When Chemistry Meets Biology in Catalysis and Synthesis

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Interfacing non-enzymatic catalysis with living microorganisms

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