Cited by 148Metal-Catalyzed Oxygenation MechanismsHemoglobin structure and functionNitric Oxide and Endothelin Effects

Generation of HNO and HSNO from Nitrite by Heme‐Iron‐Catalyzed Metabolism with H2S

Miljkovic, Jan Lj., Kenkel, Isabell, Ivanović‐Burmazović, Ivana, Filipovic, Milos R.·2013·Angewandte Chemie International Edition

Abstract

Taking NO for an answer: A mechanistic study has shown that a heme-iron-catalyzed pathway (see scheme) could lead to the nitrite-/sulfide-induced formation of NO and HNO within mitochondria, and suggests that H2S may be the elusive thiol responsible for the reduction of nitrite. This study offers an answer to the decades-old question on the role of nitrite in the treatment of H2S poisoning.

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Crossref · 10.1002/anie.201305669

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38 of 38 references verified0 citation errors · 0 not checkable

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  • Sulfide may facilitate nitrite reduction to NO via interaction with Fe3+ protoporphyrin.

    “However, sulfide may facilitate nitrite reduction to NO via interaction with Fe 3+ protoporphyrin [30], while earlier studies showed that nitrite can be reduced to NO following direct reaction with sulfide [31,32].”

    From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [30]

  • In simple aqueous solutions, nitrite does not appear to react directly with sulfide at any significant rate.

    “These observations appear to be at odds with the notion that in simple aqueous solutions nitrite does not appear to react directly with sulfide, at least not at any significant rate [30].”

    From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [30]

  • Further products of the reaction might be nitroxyl and nitrous oxide (N2O).

    “As expected, by considering the chemistry of the reaction (Fig. 2), further products of this reaction might be nitroxyl as proposed previously [16,18,30], and nitrous oxide (N2O).”

    From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [30]

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Authors
Miljkovic, J. L., Kenkel, I., Ivanović‐Burmazović, I., & Filipovic, M. R.
Affiliations
Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
Corresponding author
Ivanović‐Burmazović, Ivana
Venue
Angewandte Chemie International Edition
Publisher
Wiley
Published
2013-09-25
Volume
52
Issue
46
Pages
12061-12064
ISSN
  • 1433-7851 (ISSN-L)
  • 1521-3773
OpenAlex
W2130366736
Cited by
148
References
38
Citations by year
2026: 8 · 2025: 14 · 2024: 3 · 2023: 4 · 2022: 8 · 2021: 7 · 2020: 10 · 2019: 8 · 2018: 7 · 2017: 19 · 2016: 20 · 2015: 24 · 2014: 13 · 2013: 3
FWCI
9.41
Type
journal article
Language
en
Open access
closed
Locations
  • Angewandte Chemie International Edition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords
nitrite, hydrogen sulfide, nitric oxide, nitroxyl, nitrite reduction, mitochondria, H2S poisoning, nitrite therapy, reaction mechanism
MeSH terms
Electron Spin Resonance Spectroscopy, Heme, Humans, Hydrogen Sulfide, Iron, Mitochondria, Nitric Oxide, Nitrites, Nitrogen Oxides, Nitrous Acid, Porphyrins, Sulfur Compounds, Human Umbilical Vein Endothelial Cells

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