Nitric oxide synthase in innate and adaptive immunity: an update

Bogdan, Christian

doi:10.1016/j.it.2015.01.003

Cited by 862Nitric Oxide and Endothelin EffectsImmune Response and InflammationNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Nitric oxide synthase in innate and adaptive immunity: an update

Bogdan, Christian·2015·Trends in Immunology

DOI 10.1016/j.it.2015.01.003

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Abstract

Thirty years after the discovery of its production by activated macrophages, our appreciation of the diverse roles of nitric oxide (NO) continues to grow. Recent findings have not only expanded our understanding of the mechanisms controlling the expression of NO synthases (NOS) in innate and adaptive immune cells, but have also revealed new functions and modes of action of NO in the control and escape of infectious pathogens, in T and B cell differentiation, and in tumor defense. I discuss these findings, in the context of a comprehensive overview of the various sources and multiple reaction partners of NO, and of the regulation of NOS2 by micromilieu factors, antisense RNAs, and 'unexpected' cytokines.

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Macrophages express a cytokine-inducible NOS, resulting in high-output formation of NO needed for host responses against intracellular microbes including mycobacteria or tumor cells.
“Macrophages express a cytokine inducible NOS (iNOS) which results in high output formation of NO needed for host responses against intracellular microbes including mycobacteria or tumor cells”
From Iron in immune cell function and host defense (2021) · cites this paper as [56]

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Authors: Bogdan, C.
Affiliations: Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
Corresponding author: Bogdan, Christian
ORCID: Bogdan, Christian
Venue: Trends in Immunology
Publisher: Elsevier BV
Published: 2015-03
Volume: 36
Issue: 3
Pages: 161-178
ISSN: 1471-4906 (ISSN-L)
DOI: 10.1016/j.it.2015.01.003
OpenAlex: W2066847273
Semantic Scholar: 4c12d575cb8a803e41349babe130cfc1df89e974
Cited by: 862
References: 261
Citations by year: 2026: 54 · 2025: 52 · 2024: 61 · 2023: 88 · 2022: 82 · 2021: 92 · 2020: 96 · 2019: 87 · 2018: 89 · 2017: 73 · 2016: 61 · 2015: 25 · 2013: 1 · 2012: 1
FWCI: 10.10
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft
Doktor Robert Pfleger-Stiftung
Topics: Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords: nitric oxide synthase, nitric oxide, innate immunity, adaptive immunity, macrophages, T cell differentiation, B cell differentiation, antisense RNA, cytokines, microenvironment
MeSH terms: Bacteria, Gene Expression Regulation, Humans, Immunity, Innate, Isoenzymes, Lymphocytes, Macrophage Activation, Macrophages, Neoplasms, Nitric Oxide, Signal Transduction, STAT Transcription Factors, Interferon-Stimulated Gene Factor 3, gamma Subunit, Nitric Oxide Synthase Type II, Adaptive Immunity

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Nitric oxide synthase in innate and adaptive immunity: an update

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