The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
DNA‐Hybrid‐Gated Multifunctional Mesoporous Silica Nanocarriers for Dual‐Targeted and MicroRNA‐Responsive Controlled Drug Delivery
Abstract
The design of an ideal drug delivery system with targeted recognition and zero premature release, especially controlled and specific release that is triggered by an exclusive endogenous stimulus, is a great challenge. A traceable and aptamer‐targeted drug nanocarrier has now been developed; the nanocarrier was obtained by capping mesoporous silica‐coated quantum dots with a programmable DNA hybrid, and the drug release was controlled by microRNA. Once the nanocarriers had been delivered into HeLa cells by aptamer‐mediated recognition and endocytosis, the overexpressed endogenous miR‐21 served as an exclusive key to unlock the nanocarriers by competitive hybridization with the DNA hybrid, which led to a sustained lethality of the HeLa cells. If microRNA that is exclusively expressed in specific pathological cell was screened, a combination of chemotherapy and gene therapy should pave the way for a targeted and personalized treatment of human diseases.
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MicroRNA-21 Targets a Network of Key Tumor-Suppressive Pathways in Glioblastoma Cells
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Cited by
Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems
Karimi, M., Ghasemi, A., Sahandi Zangabad, P., Rahighi, R., Moosavi Basri, S. M., Mirshekari, H., Amiri, M., Shafaei Pishabad, Z., Aslani, A., Bozorgomid, M., et al. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00798d · Cited by 1,519
Diverse Applications of Nanomedicine
Pelaz, B., Alexiou, C., Alvarez-Puebla, R. A., Alves, F., Andrews, A. M., Ashraf, S., Balogh, L. P., Ballerini, L., Bestetti, A., Brendel, C., et al. (2017) · ACS Nano · doi:10.1021/acsnano.6b06040 · Cited by 1,350
Qiu, Z., Shu, J., & Tang, D. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b00989 · Cited by 567
DNA Functional Materials Assembled from Branched DNA: Design, Synthesis, and Applications
Dong, Y., Yao, C., Zhu, Y., Yang, L., Luo, D., & Yang, D. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00294 · Cited by 533
Sun, P., Leidner, A., Weigel, S., Weidler, P. G., Heissler, S., Scharnweber, T., & Niemeyer, C. M. (2019) · Small · doi:10.1002/smll.201900083 · Cited by 21
Metadata
- Authors
- Zhang, P., Cheng, F., Zhou, R., Cao, J., Li, J., Burda, C., Min, Q., & Zhu, J.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2014-01-27
- Volume
- 53
- Issue
- 9
- Pages
- 2371-2375
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2099651286
- Cited by
- 231
- References
- 3
- FWCI
- 13.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhang, P., Cheng, F., Zhou, R., Cao, J., Li, J., Burda, C., Min, Q., & Zhu, J. (2014). DNA‐Hybrid‐Gated Multifunctional Mesoporous Silica Nanocarriers for Dual‐Targeted and MicroRNA‐Responsive Controlled Drug Delivery. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201308920
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