The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Alkene–Tetrazine Ligation for Imaging Cellular DNA
Abstract
5‐Vinyl‐2′‐deoxyuridine (VdU) is the first reported metabolic probe for cellular DNA synthesis that can be visualized by using an inverse electron demand Diels–Alder reaction with a fluorescent tetrazine. VdU is incorporated by endogenous enzymes into the genomes of replicating cells, where it exhibits reduced genotoxicity compared to 5‐ethynyl‐2′‐deoxyuridine (EdU). The VdU–tetrazine ligation reaction is rapid (k≈0.02 M−1 s−1) and chemically orthogonal to the alkyne–azide “click” reaction of EdU‐modified DNA. Alkene–tetrazine ligation reactions provide the first alternative to azide–alkyne click reactions for the bioorthogonal chemical labeling of nucleic acids in cells and facilitate time‐resolved, multicolor labeling of DNA synthesis.
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Cites
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
Sletten, E. M., & Bertozzi, C. R. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200900942 · Cited by 3,165
Lukas, J., Lukas, C., & Bartek, J. (2011) · Nature Cell Biology · doi:10.1038/ncb2344 · Cited by 645
Cited by
Scinto, S. L., Bilodeau, D. A., Hincapie, R., Lee, W., Nguyen, S. S., Xu, M., am Ende, C. W., Finn, M. G., Lang, K., Lin, Q., et al. (2021) · Nature Reviews Methods Primers · doi:10.1038/s43586-021-00028-z · Cited by 592
Bioorthogonal Chemistry and Its Applications
Bird, R. E., Lemmel, S. A., Yu, X., & Zhou, Q. A. (2021) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.1c00461 · Cited by 409
Recent progress in non-native nucleic acid modifications
McKenzie, L. K., El-Khoury, R., Thorpe, J. D., Damha, M. J., & Hollenstein, M. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01430c · Cited by 300
Metadata
- Authors
- Rieder, U., & Luedtke, N. W.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2014-06-30
- Volume
- 53
- Issue
- 35
- Pages
- 9168-9172
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2141731346
- Cited by
- 171
- References
- 2
- FWCI
- 8.24
- Type
- journal article
- Language
- en
- Open access
- closed
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