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Chemistry for Covalent Modification of Endogenous/Native Proteins: From Test Tubes to Complex Biological Systems

Tamura, T., & Hamachi, I. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.8b11747 · Cited by 339 · see citing works

<scp>d</scp> -Amino Acid Chemical Reporters Reveal Peptidoglycan Dynamics of an Intracellular Pathogen

Siegrist, M. S., Whiteside, S., Jewett, J. C., Aditham, A., Cava, F., & Bertozzi, C. R. (2013) · ACS Chemical Biology · doi:10.1021/cb3004995 · Cited by 246 · see citing works

Rapid labelling and covalent inhibition of intracellular native proteins using ligand-directed N-acyl-N-alkyl sulfonamide

Tamura, T., Ueda, T., Goto, T., Tsukidate, T., Shapira, Y., Nishikawa, Y., Fujisawa, A., & Hamachi, I. (2018) · Nature Communications · doi:10.1038/s41467-018-04343-0 · Cited by 242 · see citing works

Non-genetic engineering of cells for drug delivery and cell-based therapy

Wang, Q., Cheng, H., Peng, H., Zhou, H., Li, P. Y., & Langer, R. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.12.003 · Cited by 225 · see citing works

Probing the Mycobacterial Trehalome with Bioorthogonal Chemistry

Swarts, B. M., Holsclaw, C. M., Jewett, J. C., Alber, M., Fox, D. M., Siegrist, M. S., Leary, J. A., Kalscheuer, R., & Bertozzi, C. R. (2012) · Journal of the American Chemical Society · doi:10.1021/ja3062419 · Cited by 184 · see citing works

Bio‐Orthogonally Crosslinked, Engineered Protein Hydrogels with Tunable Mechanics and Biochemistry for Cell Encapsulation

Madl, C. M., Katz, L. M., & Heilshorn, S. C. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201505329 · Cited by 156 · see citing works

Investigating Protein–Ligand Interactions by Solution Nuclear Magnetic Resonance Spectroscopy

Becker, W., Bhattiprolu, K. C., Gubensäk, N., & Zangger, K. (2018) · ChemPhysChem · doi:10.1002/cphc.201701253 · Cited by 138 · see citing works

Deconstructing behavioral neuropharmacology with cellular specificity

Shields, B. C., Kahuno, E., Kim, C., Apostolides, P. F., Brown, J., Lindo, S., Mensh, B. D., Dudman, J. T., Lavis, L. D., & Tadross, M. R. (2017) · Science · doi:10.1126/science.aaj2161 · Cited by 135 · see citing works

Labeling and Single-Molecule Methods To Monitor G Protein-Coupled Receptor Dynamics

Tian, H., Fürstenberg, A., & Huber, T. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00084 · Cited by 114 · see citing works

A covalent and cleavable antibody-DNA conjugation strategy for sensitive protein detection via immuno-PCR

van Buggenum, J. A. G. L., Gerlach, J. P., Eising, S., Schoonen, L., van Eijl, R. A. P. M., Tanis, S. E. J., Hogeweg, M., Hubner, N. C., van Hest, J. C., Bonger, K. M., et al. (2016) · Scientific Reports · doi:10.1038/srep22675 · Cited by 93 · see citing works

Opportunities for merging chemical and biological synthesis

Wallace, S., & Balskus, E. P. (2014) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2014.03.006 · Cited by 86 · see citing works

Global profiling of arginine reactivity and ligandability in the human proteome

Wang, Y., Hu, T., Zhu, L., Xie, S., Yang, X., Xu, C., Zhai, Y., Li, Y., Huang, X., Yang, B., et al. (2026) · Nature Chemistry · doi:10.1038/s41557-025-02012-6 · Cited by 12 · see citing works

Improved ClickTags enable live-cell barcoding for highly multiplexed single cell sequencing

Zhao, X., Sun, S., Yu, W., Zhu, W., Zhao, Z., Zhou, Y., Ding, X., Fang, N., Yang, R., & Li, J. P. (2022) · RSC Chemical Biology · doi:10.1039/d2cb00046f · Cited by 8 · see citing works

Systematic Evaluation of Bioorthogonal Reactions in Live Cells with Clickable HaloTag Ligands: Implications for Intracellular Imaging

Murrey, H. E., Judkins, J. C., Ende, C. W. A., Ballard, T. E., Fang, Y., Riccardi, K. A., Di, L., Guilmette, E. R., Schwartz, J. W., Fox, J. M., et al. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b06847 · Cited by 191 · see citing works

Bioorthogonal chemistry: Optimization and application updates during 2013–2017

Qin, L., Hu, W., & Long, Y. (2018) · Tetrahedron Letters · doi:10.1016/j.tetlet.2018.04.058 · Cited by 37 · see citing works

Tetrazine bioorthogonal chemistry derived in vivo imaging

Zhao, G., Li, Z., Zhang, R., et al. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1055823 · Cited by 24 · see citing works

Bioorthogonal Ligations and Cleavages in Chemical Biology

Li, Y., & Fu, H. (2020) · ChemistryOpen · doi:10.1002/open.202000128 · Cited by 48 · see citing works

Cell-selective bioorthogonal labeling

Huang, W., & Laughlin, S. T. (2023) · Cell chemical biology · doi:10.1016/j.chembiol.2023.09.010 · Cited by 26 · see citing works