The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Lysosomal pH Rise during Heat Shock Monitored by a Lysosome‐Targeting Near‐Infrared Ratiometric Fluorescent Probe
Abstract
Heat stroke is a life‐threatening condition, featuring a high body temperature and malfunction of many organ systems. The relationship between heat shock and lysosomes is poorly understood, mainly because of the lack of a suitable research approach. Herein, by incorporating morpholine into a stable hemicyanine skeleton, we develop a new lysosome‐targeting near‐infrared ratiometric pH probe. In combination with fluorescence imaging, we show for the first time that the lysosomal pH value increases but never decreases during heat shock, which might result from lysosomal membrane permeabilization. We also demonstrate that this lysosomal pH rise is irreversible in living cells. Moreover, the probe is easy to synthesize, and shows superior overall analytical performance as compared to the existing commercial ones. This enhanced performance may enable it to be widely used in more lysosomal models of living cells and in further revealing the mechanisms underlying heat‐related pathology.
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Impact of regional climate change on human health
Patz, J. A., Campbell-Lendrum, D., Holloway, T., & Foley, J. A. (2005) · Nature · doi:10.1038/nature04188 · Cited by 3,103
Fluorescent and colorimetric sensors for detection of lead, cadmium, and mercury ions
Kim, H. N., Ren, W. X., Kim, J. S., & Yoon, J. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15245a · Cited by 2,253
A lysosome‐to‐nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
Settembre, C., Zoncu, R., Medina, D. L., Vetrini, F., Erdin, S., Erdin, S., Huynh, T., Ferron, M., Karsenty, G., Vellard, M. C., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.32 · Cited by 1,920
Design Strategies for Water-Soluble Small Molecular Chromogenic and Fluorogenic Probes
Li, X., Gao, X., Shi, W., & Ma, H. (2014) · Chemical Reviews · doi:10.1021/cr300508p · Cited by 1,729
Self-citationFluorescent Indicators for Intracellular pH
Han, J., & Burgess, K. (2010) · Chemical Reviews · doi:10.1021/cr900249z · Cited by 1,620
Aitken, C. E., Marshall, R. A., & Puglisi, J. D. (2008) · Biophysical Journal · doi:10.1529/biophysj.107.117689 · Cited by 843
The Art of Fluorescence Imaging with Chemical Sensors
Schäferling, M. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201105459 · Cited by 721
A Unique Approach to Development of Near-Infrared Fluorescent Sensors for in Vivo Imaging
Yuan, L., Lin, W., Zhao, S., Gao, W., Chen, B., He, L., & Zhu, S. (2012) · Journal of the American Chemical Society · doi:10.1021/ja305802v · Cited by 679
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Activatable Molecular Probes With Clinical Promise for NIR‐II Fluorescent Imaging
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Metadata
- Authors
- Wan, Q., Chen, S., Shi, W., Li, L., & Ma, H.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2014-08-22
- Volume
- 53
- Issue
- 41
- Pages
- 10916-10920
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2095893897
- Cited by
- 420
- References
- 37
- FWCI
- 17.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wan, Q., Chen, S., Shi, W., Li, L., & Ma, H. (2014). Lysosomal pH Rise during Heat Shock Monitored by a Lysosome‐Targeting Near‐Infrared Ratiometric Fluorescent Probe. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201405742
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