The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Photocaged DNAzymes as a General Method for Sensing Metal Ions in Living Cells
Open accessAbstract
DNAzymes, which are sequences of DNA with catalytic activity, have been demonstrated as a potential platform for sensing a wide range of metal ions. Despite their significant promise, cellular sensing using DNAzymes has however been difficult, mainly because of the “always‐on” mode of first‐generation DNAzyme sensors. To overcome this limitation, a photoactivatable (or photocaged) DNAzyme was designed and synthesized, and its application in sensing Zn II in living cells was demonstrated. In this design, the adenosine ribonucleotide at the scissile position of the 8–17 DNAzyme was replaced by 2′‐O‐nitrobenzyl adenosine, rendering the DNAzyme inactive and thus allowing its delivery into cells intact, protected from nonspecific degradation within cells. Irradiation at 365 nm restored DNAzyme activity, thus allowing the temporal control over the sensing activity of the DNAzyme for metal ions. The same strategy was also applied to the GR‐5 DNAzyme for the detection of Pb II, thus demonstrating the possible scope of the method.
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Clapham, D. E. (2007) · Cell · doi:10.1016/j.cell.2007.11.028 · Cited by 4,175
Femtomolar Sensitivity of Metalloregulatory Proteins Controlling Zinc Homeostasis
Outten, C. E., & O'Halloran, A. T. V. (2001) · Science · doi:10.1126/science.1060331 · Cited by 1,489
Imaging mobile zinc in biology
Tomat, E., & Lippard, S. J. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2009.12.010 · Cited by 217
Cited by
Zhou, W., Saran, R., & Liu, J. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00063 · Cited by 931
A microRNA-initiated DNAzyme motor operating in living cells
Peng, H., Li, X.-F., Zhang, H., & Le, X. C. (2017) · Nature Communications · doi:10.1038/ncomms14378 · Cited by 577
McConnell, E. M., Cozma, I., Mou, Q., Brennan, J. D., Lu, Y., & Li, Y. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00240f · Cited by 477
Self-citationOptochemical Control of Biological Processes in Cells and Animals
Ankenbruck, N., Courtney, T., Naro, Y., & Deiters, A. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201700171 · Cited by 419
Upconversion Luminescence-Activated DNA Nanodevice for ATP Sensing in Living Cells
Zhao, J., Gao, J., Xue, W., Di, Z., Xing, H., Lu, Y., & Li, L. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.7b11161 · Cited by 361
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Metadata
- Authors
- Hwang, K., Wu, P., Kim, T., Lei, L., Tian, S., Wang, Y., & Lu, Y.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2014-10-14
- Volume
- 53
- Issue
- 50
- Pages
- 13798-13802
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2105915844
- Cited by
- 213
- References
- 3
- FWCI
- 6.08
- Type
- journal article
- Language
- en
- Open access
- green
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- Hwang, K., Wu, P., Kim, T., Lei, L., Tian, S., Wang, Y., & Lu, Y. (2014). Photocaged DNAzymes as a General Method for Sensing Metal Ions in Living Cells. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201408333
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