The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
A microRNA-initiated DNAzyme motor operating in living cells
Open accessAbstract
Synthetic DNA motors have great potential to mimic natural protein motors in cells but the operation of synthetic DNA motors in living cells remains challenging and has not been demonstrated. Here we report a DNAzyme motor that operates in living cells in response to a specific intracellular target. The whole motor system is constructed on a 20 nm gold nanoparticle (AuNP) decorated with hundreds of substrate strands serving as DNA tracks and dozens of DNAzyme molecules each silenced by a locking strand. Intracellular interaction of a target molecule with the motor system initiates the autonomous walking of the motor on the AuNP. An example DNAzyme motor responsive to a specific microRNA enables amplified detection of the specific microRNA in individual cancer cells. Activated by specific intracellular targets, these self-powered DNAzyme motors will have diverse applications in the control and modulation of biological functions.
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Cites
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
Ma, L., Teruya-Feldstein, J., & Weinberg, R. A. (2007) · Nature · doi:10.1038/nature06174 · Cited by 2,605
The Molecular Motor Toolbox for Intracellular Transport
Vale, R. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00111-9 · Cited by 1,982
Kinesin superfamily motor proteins and intracellular transport
Hirokawa, N., Noda, Y., Tanaka, Y., & Niwa, S. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2774 · Cited by 1,859 · cited 1×
“ells use protein motors to transport molecules and organelles along cytoskeleton tracks, allowing a high degree of spatial and temporal organization of cellular molecules and organelles 1–3 .”
Yildiz, A., Tomishige, M., Vale, R. D., & Selvin, P. R. (2004) · Science · doi:10.1126/science.1093753 · Cited by 965
DNA nanotechnology from the test tube to the cell
Chen, Y.-J., Groves, B., Muscat, R. A., & Seelig, G. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.195 · Cited by 594 · cited 1×
“Although various synthetic DNA motors have been tested in vitro , the ultimate goal of introducing them into cells to perform specific biological functions has not yet been achieved 33–35 .”
Cited by
Rational Engineering of a Dynamic, Entropy‐Driven DNA Nanomachine for Intracellular MicroRNA Imaging
Liang, C., Ma, P., Liu, H., Guo, X., Yin, B., & Ye, B. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201704147 · Cited by 389
Upconversion Luminescence-Activated DNA Nanodevice for ATP Sensing in Living Cells
Zhao, J., Gao, J., Xue, W., Di, Z., Xing, H., Lu, Y., & Li, L. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.7b11161 · Cited by 361
Static DNA Nanostructures For Cancer Theranostics: Recent Progress In Design And Applications
Jahanban-Esfahlan, R., Seidi, K., Jahanban-Esfahlan, A., Jaymand, M., Alizadeh, E., Majdi, H., Najjar, R., Javaheri, T., & Zare, P. (2019) · Nanotechnology, Science and Applications · doi:10.2147/nsa.s227193 · Cited by 50
Metadata
- Authors
- Peng, H., Li, X.-F., Zhang, H., & Le, X. C.
- Venue
- Nature Communications
- Published
- 2017-03-06
- Volume
- 8
- Issue
- 1
- Pages
- 14378-14378
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2594377120
- Cited by
- 577
- References
- 5
- FWCI
- 21.35
- Type
- journal article
- Language
- en
- Open access
- gold
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