The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Hypoxia Induced by Upconversion‐Based Photodynamic Therapy: Towards Highly Effective Synergistic Bioreductive Therapy in Tumors
Abstract
Local hypoxia in tumors is an undesirable consequence of photodynamic therapy (PDT), which will lead to greatly reduced effectiveness of this therapy. Bioreductive pro‐drugs that can be activated at low‐oxygen conditions will be highly cytotoxic under hypoxia in tumors. Based on this principle, double silica‐shelled upconversion nanoparticles (UCNPs) nanostructure capable of co‐delivering photosensitizer (PS) molecules and a bioreductive pro‐drug (tirapazamine, TPZ) were designed (TPZ‐UC/PS), with which a synergetic tumor therapeutic effect has been achieved first by UC‐based (UC‐) PDT under normal oxygen environment, immediately followed by the induced cytotoxicity of activated TPZ when oxygen is depleted by UC‐PDT. Treatment with TPZ‐UC/PS plus NIR laser resulted in a remarkably suppressed tumor growth as compared to UC‐PDT alone, implying that the delivered TPZ has a profound effect on treatment outcomes for the much‐enhanced cytotoxicity of TPZ under PDT‐induced hypoxia.
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Phthalocyanines as medicinal photosensitizers: Developments in the last five years
Li, X., Zheng, B.-D., Peng, X.-H., Li, S.-Z., Ying, J.-W., Zhao, Y., Huang, J.-D., & Yoon, J. (2019) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2017.08.003 · Cited by 523
The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors
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Metadata
- Authors
- Liu, Y., Liu, Y., Bu, W., Cheng, C., Zuo, C., Xiao, Q., Sun, Y., Ni, D., Zhang, C., Liu, J., & Shi, J.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2015-05-26
- Volume
- 54
- Issue
- 28
- Pages
- 8105-8109
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2102907645
- Cited by
- 425
- References
- 23
- FWCI
- 24.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Liu, Y., Liu, Y., Bu, W., Cheng, C., Zuo, C., Xiao, Q., Sun, Y., Ni, D., Zhang, C., Liu, J., & Shi, J. (2015). Hypoxia Induced by Upconversion‐Based Photodynamic Therapy: Towards Highly Effective Synergistic Bioreductive Therapy in Tumors. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201500478
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