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Noninvasive Staging of Kidney Dysfunction Enabled by Renal‐Clearable Luminescent Gold Nanoparticles
Open accessAbstract
As a “silent killer”, kidney disease is often hardly detected at an early stage but can cause lethal kidney failure later on. Thus, a preclinical imaging technique that can readily differentiate between the stages of kidney dysfunction is highly desired for improving our fundamental understanding of kidney disease progression. Herein, we report that in vivo fluorescence imaging, enabled by renal‐clearable near‐infrared‐emitting gold nanoparticles, can noninvasively detect kidney dysfunction, report on the dysfunctional stages, and even reveal adaptive function in a mouse model of unilateral obstructive nephropathy, which cannot be diagnosed with routine kidney function markers. These results demonstrate that low‐cost fluorescence kidney functional imaging is highly sensitive and useful for the longitudinal, noninvasive monitoring of kidney dysfunction progression in preclinical research.
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Citations
Cited by
Transport and interactions of nanoparticles in the kidneys
Du, B., Yu, M., & Zheng, J. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0038-3 · Cited by 649
Self-citationXu, M., Qi, Y., Liu, G., Song, Y., Jiang, X., & Du, B. (2023) · ACS Nano · doi:10.1021/acsnano.3c05853 · Cited by 632
Self-citationNear-infrared luminescence high-contrast in vivo biomedical imaging
Chen, Y., Wang, S., & Zhang, F. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-022-00002-8 · Cited by 566
Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice
Ni, D., Jiang, D., Kutyreff, C. J., Lai, J., Yan, Y., Barnhart, T. E., Yu, B., Im, H.-J., Kang, L., Cho, S. Y., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07890-8 · Cited by 313
Huang, J., Xie, C., Zhang, X., Jiang, Y., Li, J., Fan, Q., & Pu, K. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201909560 · Cited by 258
Metadata
- Authors
- Yu, M., Zhou, J., Du, B., Ning, X., Authement, C., Gandee, L., Kapur, P., Hsieh, J., & Zheng, J.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2016-01-22
- Volume
- 55
- Issue
- 8
- Pages
- 2787-2791
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2291540813
- Cited by
- 174
- References
- 0
- FWCI
- 15.24
- Type
- journal article
- Language
- en
- Open access
- green
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- Yu, M., Zhou, J., Du, B., Ning, X., Authement, C., Gandee, L., Kapur, P., Hsieh, J., & Zheng, J. (2016). Noninvasive Staging of Kidney Dysfunction Enabled by Renal‐Clearable Luminescent Gold Nanoparticles. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201511148
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