The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice
Open accessAbstract
Acute kidney injury (AKI) is a common reactive oxygen species (ROS)-related renal disease that causes numerous deaths annually, yet only supportive treatment is currently available in the clinics. Development of antioxidants with high accumulation rates in kidneys is highly desired to help prevent AKI. Here we report molybdenum-based polyoxometalate (POM) nanoclusters with preferential renal uptake as novel nano-antioxidants for kidney protection. These POM nanoclusters, with a readily variable valence state of molybdenum ions, possess the capability to scavenge detrimental ROS. Our results demonstrate that POM nanoclusters can efficiently alleviate clinical symptoms in mice subjected to AKI, as verified by dynamic PET imaging with 68 Ga-EDTA, serum tests, kidney tissue staining, and biomarkers detection in the kidneys. The protective effect of POM nanoclusters against AKI in living animals suggests exploring their use for the treatment of AKI patients, as well as patients with other ROS-related diseases.
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Self-citation
Metadata
- Authors
- Ni, D., Jiang, D., Kutyreff, C. J., Lai, J., Yan, Y., Barnhart, T. E., Yu, B., Im, H.-J., Kang, L., Cho, S. Y., Liu, Z., Huang, P., Engle, J. W., & Cai, W.
- Venue
- Nature Communications
- Published
- 2018-12-21
- Volume
- 9
- Issue
- 1
- Pages
- 5421-5421
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2905491630
- Cited by
- 313
- References
- 53
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- gold
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- Ni, D., Jiang, D., Kutyreff, C. J., Lai, J., Yan, Y., Barnhart, T. E., Yu, B., Im, H.-J., Kang, L., Cho, S. Y., Liu, Z., Huang, P., Engle, J. W., & Cai, W. (2018). Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice. Nature Communications. https://doi.org/10.1038/s41467-018-07890-8
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