The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Mitochondria‐Targeted Photosensitizer Showing Improved Photodynamic Therapy Effects Under Hypoxia
Abstract
Organelle‐targeted photosensitizers have been reported to be effective photodynamic therapy (PDT) agents. In this work, we designed and synthesized two iridium(III) complexes that specifically stain the mitochondria and lysosomes of living cells, respectively. Both complexes exhibited long‐lived phosphorescence, which is sensitive to oxygen quenching. The photocytotoxicity of the complexes was evaluated under normoxic and hypoxic conditions. The results showed that HeLa cells treated with the mitochondria‐targeted complex maintained a slower respiration rate, leading to a higher intracellular oxygen level under hypoxia. As a result, this complex exhibited an improved PDT effect compared to the lysosome‐targeted complex, especially under hypoxia conditions, suggestive of a higher practicable potential of mitochondria‐targeted PDT agents in cancer therapy.
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Targeting hypoxia in cancer therapy
Wilson, W. R., & Hay, M. P. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3064 · Cited by 3,172
Cheng, Y., Cheng, H., Jiang, C., Qiu, X., Wang, K., Huan, W., Yuan, A., Wu, J., & Hu, Y. (2015) · Nature Communications · doi:10.1038/ncomms9785 · Cited by 941
Cited by
Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813
Zielonka, J., Joseph, J., Sikora, A., Hardy, M., Ouari, O., Vasquez-Vivar, J., Cheng, G., Lopez, M., & Kalyanaraman, B. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00042 · Cited by 1,683
Recent advances in nanomedicines for photodynamic therapy (PDT)-driven cancer immunotherapy
Ji, B., Wei, M., & Yang, B. (2022) · Theranostics · doi:10.7150/thno.67300 · Cited by 544
Microenvironment‐Responsive Prodrug‐Induced Pyroptosis Boosts Cancer Immunotherapy
Xiao, Y., Zhang, T., Ma, X., Yang, Q., Yang, L., Yang, S., Liang, M., Xu, Z., & Sun, Z. (2021) · Advanced Science · doi:10.1002/advs.202101840 · Cited by 325
Lee, L. C.-C., & Lo, K. K.-W. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c03437 · Cited by 279
Metadata
- Authors
- Lv, W., Zhang, Z., Zhang, K. Y., Yang, H., Liu, S., Xu, A., Guo, S., Zhao, Q., & Huang, W.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2016-07-06
- Volume
- 55
- Issue
- 34
- Pages
- 9947-9951
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2462685703
- Cited by
- 523
- References
- 2
- FWCI
- 49.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lv, W., Zhang, Z., Zhang, K. Y., Yang, H., Liu, S., Xu, A., Guo, S., Zhao, Q., & Huang, W. (2016). A Mitochondria‐Targeted Photosensitizer Showing Improved Photodynamic Therapy Effects Under Hypoxia. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201604130
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