The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A DNAzyme Feedback Amplification Strategy for Biosensing
Abstract
We report a signal amplification strategy termed DNAzyme feedback amplification (DFA) that takes advantage of rolling‐circle amplification (RCA) and an RNA‐cleaving DNAzyme (RCD). DFA employs two specially programmed DNA complexes, one composed of a primer and a circular template containing the antisense sequence of an RCD, and the other composed of the same circular template and an RNA‐containing substrate for the RCD. RCA is initiated at the first complex to produce RCD elements that go on to cleave the substrate in the second complex. This cleavage event triggers the production of more input complexes for RCA. This reaction circuit continues autonomously, resulting in exponential DNA amplification. We demonstrate the versatility of this approach for biosensing through the design of DFA systems capable of detecting a microRNA sequence and a bacterium, with sensitivity improvements of 3–6 orders of magnitude over conventional methods.
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Saiki, R. K., Scharf, S., Faloona, F., Mullis, K. B., Horn, G. T., Erlich, H. A., & Arnheim, N. (1985) · Science · doi:10.1126/science.2999980 · Cited by 8,956
Diversifying microRNA sequence and function
Ameres, S. L., & Zamore, P. D. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3611 · Cited by 1,175
miR‐21: a small multi‐faceted RNA
Krichevsky, A. M., & Gabriely, G. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00556.x · Cited by 987
Cited by
McConnell, E. M., Cozma, I., Mou, Q., Brennan, J. D., Lu, Y., & Li, Y. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00240f · Cited by 477
Self-citationA CRISPR-Cas autocatalysis-driven feedback amplification network for supersensitive DNA diagnostics
Shi, K., Xie, S., Tian, R., Wang, S., Lu, Q., Gao, D., Lei, C., Zhu, H., & Nie, Z. (2021) · Science Advances · doi:10.1126/sciadv.abc7802 · Cited by 334
Metadata
- Authors
- Liu, M., Zhang, Q., Chang, D., Gu, J., Brennan, J. D., & Li, Y.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2017-03-28
- Volume
- 56
- Issue
- 22
- Pages
- 6142-6146
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2601600255
- Cited by
- 161
- References
- 3
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liu, M., Zhang, Q., Chang, D., Gu, J., Brennan, J. D., & Li, Y. (2017). A DNAzyme Feedback Amplification Strategy for Biosensing. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201700054
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