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Rational Design of a Robust Fluorescent Probe for the Detection of Endogenous Carbon Monoxide in Living Zebrafish Embryos and Mouse Tissue
Abstract
Carbon monoxide (CO) is one of the most important gaseous signal molecules in biological systems. However, the investigation of the functions of CO in living organisms is restricted by the lack of functional molecular tools. To address this critical challenge, we present herein the rational design, synthesis, and in vivo imaging studies of a powerful two‐photon excited near‐infrared fluorescent probe (1‐Ac) for endogenous CO monitoring. The advantageous features of the new probe include high stability, low background fluorescence, large fluorescence enhancement, high sensitivity, and two‐photon excitation with emission in the near‐infrared region. Significantly, these merits of the probe enable the tracking of endogenous CO in zebrafish embryos and mouse tissues for the first time.
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Cited by
Recent advances in near-infrared II fluorophores for multifunctional biomedical imaging
Ding, F., Zhan, Y., Lu, X., & Sun, Y. (2018) · Chemical Science · doi:10.1039/c8sc01153b · Cited by 538
Hybrid Rhodamine Fluorophores in the Visible/NIR Region for Biological Imaging
Wang, L., Du, W., Hu, Z., Uvdal, K., Li, L., & Huang, W. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201901061 · Cited by 348
Wu, L., Liu, J., Li, P., Tang, B., & James, T. D. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00861c · Cited by 348
Li, H., Yao, Q., Xu, F., Xu, N., Duan, R., Long, S., Fan, J., Du, J., Wang, J., & Peng, X. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.06.028 · Cited by 109
Metadata
- Authors
- Liu, K., Kong, X., Ma, Y., & Lin, W.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2017-10-06
- Volume
- 56
- Issue
- 43
- Pages
- 13489-13492
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2751457053
- Cited by
- 173
- References
- 0
- FWCI
- 8.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Rational Design of a Robust Fluorescent Probe for the Detection of Endogenous Carbon Monoxide in Living Zebrafish Embryos and Mouse Tissue. https://app.cochat.ai/papers/10.1002/anie.201707518
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- Liu, K., Kong, X., Ma, Y., & Lin, W. (2017). Rational Design of a Robust Fluorescent Probe for the Detection of Endogenous Carbon Monoxide in Living Zebrafish Embryos and Mouse Tissue. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201707518
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