The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Semiconducting Polymer Nano‐prodrug for Hypoxia‐Activated Photodynamic Cancer Therapy
Abstract
Photodynamic therapy (PDT) holds great promise for cancer therapy; however, its efficacy is often compromised by tumor hypoxia. Herein, we report the synthesis of a semiconducting polymer nanoprodrug (SPNpd) that not only efficiently generates singlet oxygen (1 O 2) under NIR photoirradiation but also specifically activates its chemotherapeutic action in hypoxic tumor microenvironment. SPNpd is self‐assembled from a amphiphilic polymer brush, which comprises a light‐responsive photodynamic backbone grafted with poly(ethylene glycol) and conjugated with a chemodrug through hypoxia‐cleavable linkers. The well‐defined and compact nanostructure of SPNpd (30 nm) enables accumulation in the tumor of living mice. Owing to these features, SPNpd exerts synergistic photodynamic and chemo‐therapy, and effectively inhibits tumor growth in a xenograft tumor mouse model. This study represents the first hypoxia‐activatable phototherapeutic polymeric prodrug system with a high potential for cancer therapy.
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Cheng, Y., Cheng, H., Jiang, C., Qiu, X., Wang, K., Huan, W., Yuan, A., Wu, J., & Hu, Y. (2015) · Nature Communications · doi:10.1038/ncomms9785 · Cited by 941
Hong, G., Zou, Y., Antaris, A. L., Diao, S., Wu, D., Cheng, K., Zhang, X., Chen, C., Liu, B., He, Y., et al. (2014) · Nature Communications · doi:10.1038/ncomms5206 · Cited by 563
Cited by
Second near-infrared photothermal materials for combinational nanotheranostics
Xu, C., & Pu, K. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00664e · Cited by 941
Self-citationRecent advances in nanomedicines for photodynamic therapy (PDT)-driven cancer immunotherapy
Ji, B., Wei, M., & Yang, B. (2022) · Theranostics · doi:10.7150/thno.67300 · Cited by 544
Tian, H., Zhang, T., Qin, S., Huang, Z., Zhou, L., Shi, J., Nice, E. C., Xie, N., Huang, C., & Shen, Z. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01320-5 · Cited by 426
Semiconducting Polymer Nanomaterials as Near-Infrared Photoactivatable Protherapeutics for Cancer
Li, J., & Pu, K. (2020) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00569 · Cited by 412
Self-citationStimuli-Responsive Polymer-Based Nanosystems for Cancer Theranostics
Wei, D., Sun, Y., Zhu, H., & Fu, Q. (2023) · ACS Nano · doi:10.1021/acsnano.3c06019 · Cited by 303
Metadata
- Authors
- Cui, D., Huang, J., Zhen, X., Li, J., Jiang, Y., & Pu, K.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2019-03-26
- Volume
- 58
- Issue
- 18
- Pages
- 5920-5924
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2916429698
- Cited by
- 340
- References
- 2
- FWCI
- 21.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cui, D., Huang, J., Zhen, X., Li, J., Jiang, Y., & Pu, K. (2019). A Semiconducting Polymer Nano‐prodrug for Hypoxia‐Activated Photodynamic Cancer Therapy. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201814730
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