The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Luminescent, Oxygen‐Supplying, Hemoglobin‐Linked Conjugated Polymer Nanoparticles for Photodynamic Therapy
Abstract
Photodynamic therapy (PDT) is a promising method for cancer treatment. Two parameters that influence the efficacy of PDT are the light source and oxygen supply. Herein, we prepared a system for PDT using hemoglobin (Hb)‐linked conjugated polymer nanoparticles (CPNs), which can luminesce and supply oxygen. Hb catalyzes the activation of luminol, the conjugated polymer poly[2‐methoxy‐5‐(2‐ethylhexyloxy)‐1,4‐phenylenevinylene] (MEH–PPV) nanoparticles can absorb the chemiluminescence of luminol through chemiluminescence resonance energy transfer (CRET) and then sensitize the oxygen supplied by Hb to produce reactive oxygen species that kill cancer cells. This system could be used for the controlled release of an anticancer prodrug. The system does not need an external light source and circumvents the insufficient level molecular oxygen under hypoxia. This work provides a proof‐of‐concept to explore smart and multifunctional nanoplatforms for phototherapy.
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Cites
Targeting hypoxia in cancer therapy
Wilson, W. R., & Hay, M. P. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3064 · Cited by 3,172
Cited by
Conquering the Hypoxia Limitation for Photodynamic Therapy
Wan, Y., Fu, L., Li, C., Lin, J., & Huang, P. (2021) · Advanced Materials · doi:10.1002/adma.202103978 · Cited by 705
Overcoming barriers in photodynamic therapy harnessing nano-formulation strategies
Xie, J., Wang, Y., Choi, W., Jangili, P., Ge, Y., Xu, Y., Kang, J., Liu, L., Zhang, B., Xie, Z., et al. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01370f · Cited by 522
Self-citationPhototherapy in cancer treatment: strategies and challenges
Cai, Y., Chai, T., Nguyen, W., Liu, J., Xiao, E., Ran, X., Ran, Y., Du, D., Chen, W., & Chen, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02140-y · Cited by 453
Reactive Oxygen Species‐Regulating Strategies Based on Nanomaterials for Disease Treatment
Zhang, C., Wang, X., Du, J., Gu, Z., & Zhao, Y. (2021) · Advanced Science · doi:10.1002/advs.202002797 · Cited by 401
Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments
Kolarikova, M., Hosikova, B., Dilenko, H., Barton‐Tomankova, K., Valkova, L., Bajgar, R., Malina, L., & Kolarova, H. (2023) · Medicinal Research Reviews · doi:10.1002/med.21935 · Cited by 282
Metadata
- Authors
- Jiang, L., Bai, H., Liu, L., Lv, F., Ren, X., & Wang, S.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2019-06-27
- Volume
- 58
- Issue
- 31
- Pages
- 10660-10665
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2955531389
- Cited by
- 288
- References
- 1
- FWCI
- 11.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jiang, L., Bai, H., Liu, L., Lv, F., Ren, X., & Wang, S. (2019). Luminescent, Oxygen‐Supplying, Hemoglobin‐Linked Conjugated Polymer Nanoparticles for Photodynamic Therapy. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201905884
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