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Ultrasound‐Activated Sensitizers and Applications
Abstract
Modalities for photo‐triggered anticancer therapy are usually limited by their low penetrative depth. Sonotheranostics especially sonodynamic therapy (SDT), which is different from photodynamic therapy (PDT) by the use of highly penetrating acoustic waves to activate a class of sound‐responsive materials called sonosensitizers, has gained significant interest in recent years. The effect of SDT is closely related to the structural and physicochemical properties of the sonosensitizers, which has led to the development of new sound‐activated materials as sonosensitizers for various biomedical applications. This Review provides a summary and discussion of the types of novel sonosensitizers developed in the last few years and outlines their specific designs and the potential challenges. The applications of sonosensitizers with various functions such as for imaging and drug delivery as well as in combination with other treatment modalities would provide new strategies for disease therapy.
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“SDT employs ultrasound (US) to activate sonosensitizers, which selectively accumulate in tumor tissues. Upon activation, these sonosensitizers generate reactive oxygen species (ROS), targeting and destroying tumor cells while minimizing damage to surrounding normal tissues from damage [10–13].”
From Nanosensitizer-assisted sonodynamic therapy for breast cancer (2025) · cites this paper as [10]
In the citing paper
“Sonodynamic therapy (SDT), a new strategy for tumor treatment, has non-invasive, highly controllable, deep tissue penetration, and targeted ability.”
From Nanosensitizer-assisted sonodynamic therapy for breast cancer (2025) · cites this paper as [10]
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Yu, W., Fu, J., Chen, Y., Mu, Y., Jin, Q., Wang, Y., & Ji, J. (2025) · Materials Horizons · doi:10.1039/d5mh00253b · Cited by 4
Pancatalytic Tumor Therapy by Ultrasound Activation of Inorganic Sonosensitizers
Cheng, F., Tian, Y., & Chen, Y. (2025) · ChemBioChem · doi:10.1002/cbic.202500440 · Cited by 4
Peng, Y., Li, Z., Zhou, L., Qian, J., Yin, B., Sun, B., Song, Y., Chen, H., Tan, X.-Z., Duan, X., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03674-7 · Cited by 4
Virus-inspired nanocages potentiate glioblastoma sonochemotherapy via structure-function mimicry
Liu, X., Ma, J., Zhang, Y., Li, L. L., Li, L., Chen, E., Tian, X., Wei, F., & Lin, X. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.10.025 · Cited by 5
Self-citationDefect‐Rich 2D Layered Double Hydroxides Enhance Sonodynamic Antibacterial Therapy
Liu, Q., Yang, Y., Zhao, R., Huang, L., Qi, X., Wu, M., & Shen, J. (2026) · Advanced Science · doi:10.1002/advs.202524216 · Cited by 4
Çalışkan, M., Sağkan, R. I., Bayrak, G., & Çalışkan, S. Ö. (2024) · Journal of Ultrasound in Medicine · doi:10.1002/jum.16575 · Cited by 4
Ravichandran, V., Hoang, Q. T., Cao, T. G. N., & Shim, M. S. (2022) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2022.07.007 · Cited by 4
Metadata
- Authors
- Lin, X., Song, J., Chen, X., & Yang, H.
- Affiliations
- Fuzhou University (CN)
- National Institutes of Health (US)
- Corresponding author
- Song, Jibin
- Chen, Xiaoyuan
- Yang, Huanghao
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2020-05-11
- Volume
- 59
- Issue
- 34
- Pages
- 14212-14233
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2953592429
- Cited by
- 501
- References
- 207
- Citations by year
- 2026: 54 · 2025: 93 · 2024: 95 · 2023: 110 · 2022: 61 · 2021: 63 · 2020: 22
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Biomedical Imaging and Bioengineering (ZIA EB000073)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Keywords
- sonosensitizer, sonodynamic therapy, imaging, drug delivery, combination therapy
- MeSH terms
- Antineoplastic Agents, Combined Modality Therapy, Humans, Neoplasms, Ultrasonic Therapy, Precision Medicine
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