Cited by 501Nanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesUltrasound and Hyperthermia Applications

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Ultrasound‐Activated Sensitizers and Applications

Lin, Xiahui, Song, Jibin, Chen, Xiaoyuan, Yang, Huanghao·2020·Angewandte Chemie International Edition

DOI 10.1002/anie.201906823

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Abstract

Modalities for photo‐triggered anticancer therapy are usually limited by their low penetrative depth. Sonotheranostics especially sonodynamic therapy (SDT), which is different from photodynamic therapy (PDT) by the use of highly penetrating acoustic waves to activate a class of sound‐responsive materials called sonosensitizers, has gained significant interest in recent years. The effect of SDT is closely related to the structural and physicochemical properties of the sonosensitizers, which has led to the development of new sound‐activated materials as sonosensitizers for various biomedical applications. This Review provides a summary and discussion of the types of novel sonosensitizers developed in the last few years and outlines their specific designs and the potential challenges. The applications of sonosensitizers with various functions such as for imaging and drug delivery as well as in combination with other treatment modalities would provide new strategies for disease therapy.

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Authors: Lin, X., Song, J., Chen, X., & Yang, H.
Affiliations: Fuzhou University (CN)
National Institutes of Health (US)
Corresponding author: Song, Jibin
Chen, Xiaoyuan
Yang, Huanghao
ORCID: Lin, Xiahui
Song, Jibin
Chen, Xiaoyuan
Yang, Huanghao
Venue: Angewandte Chemie International Edition
Publisher: Wiley
Published: 2020-05-11
Volume: 59
Issue: 34
Pages: 14212-14233
ISSN: 1433-7851 (ISSN-L)
1521-3773
DOI: 10.1002/anie.201906823
OpenAlex: W2953592429
Cited by: 501
References: 207
Citations by year: 2026: 54 · 2025: 93 · 2024: 95 · 2023: 110 · 2022: 61 · 2021: 63 · 2020: 22
FWCI: 3.00
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Angewandte Chemie International Edition (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Biomedical Imaging and Bioengineering (ZIA EB000073)
Topics: Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
Keywords: sonosensitizer, sonodynamic therapy, imaging, drug delivery, combination therapy
MeSH terms: Antineoplastic Agents, Combined Modality Therapy, Humans, Neoplasms, Ultrasonic Therapy, Precision Medicine

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Ultrasound‐Activated Sensitizers and Applications

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