The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Enhanced Antitumor Efficacy by a Cascade of Reactive Oxygen Species Generation and Drug Release
Abstract
Reactive oxygen species (ROS) can be used not only as a therapeutic agent for chemodynamic therapy (CDT), but also as a stimulus to activate release of antitumor drugs, achieving enhanced efficacy through the combination of CDT and chemotherapy. Here we report a pH/ROS dual‐responsive nanomedicine consisting of β‐lapachone (Lap), a pH‐responsive polymer, and a ROS‐responsive polyprodrug. In the intracellular acidic environment, the nanomedicine can realize pH‐triggered disassembly. The released Lap can efficiently generate hydrogen peroxide, which will be further converted into highly toxic hydroxyl radicals via the Fenton reaction. Subsequently, through ROS‐induced cleavage of thioketal linker, doxorubicin is released from the polyprodrug. In vivo results indicate that the cascade of ROS generation and antitumor‐drug release can effectively inhibit tumor growth. This design of nanomedicine with cascade reactions offers a promising strategy to enhance antitumor efficacy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
Trachootham, D., Alexandre, J., & Huang, P. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2803 · Cited by 5,452
Chemistry and biology of reactive oxygen species in signaling or stress responses
Dickinson, B. C., & Chang, C. J. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.607 · Cited by 1,821
Cited by
Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances
Jia, C., Guo, Y., & Wu, F. (2022) · Small · doi:10.1002/smll.202103868 · Cited by 685
pH-Responsive Polymer Nanomaterials for Tumor Therapy
Chu, S., Shi, X., Tian, Y., & Gao, F. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.855019 · Cited by 300
Liu, B., Bian, Y., Liang, S., Yuan, M., Dong, S., He, F., Gai, S., Yang, P., Cheng, Z., & Lin, J. (2022) · ACS Nano · doi:10.1021/acsnano.1c07893 · Cited by 257
Endogenous Hydrogen Sulfide-Triggered MOF-Based Nanoenzyme for Synergic Cancer Therapy
Li, Y., Zhou, J., Wang, L., & Xie, Z. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c08659 · Cited by 125
Metadata
- Authors
- Wang, S., Yu, G., Wang, Z., Jacobson, O., Lin, L., Yang, W., Deng, H., He, Z., Liu, Y., Chen, Z., & Chen, X.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2019-09-03
- Volume
- 58
- Issue
- 41
- Pages
- 14758-14763
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2969630904
- Cited by
- 270
- References
- 2
- FWCI
- 13.93
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Enhanced Antitumor Efficacy by a Cascade of Reactive Oxygen Species Generation and Drug Release. https://app.cochat.ai/papers/10.1002/anie.201908997
- The paper
- Wang, S., Yu, G., Wang, Z., Jacobson, O., Lin, L., Yang, W., Deng, H., He, Z., Liu, Y., Chen, Z., & Chen, X. (2019). Enhanced Antitumor Efficacy by a Cascade of Reactive Oxygen Species Generation and Drug Release. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201908997
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
