Cited by 125Nanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisMetal-Organic Frameworks: Synthesis and Applications

Endogenous Hydrogen Sulfide-Triggered MOF-Based Nanoenzyme for Synergic Cancer Therapy

Li, Yite, Zhou, Junli, Wang, Lei, Xie, Zhigang·2020·ACS Applied Materials & Interfaces

Abstract

The developing nanoparticle therapeutic agents triggered by tumor microenvironment are a feasible strategy for the substantial elevation of accuracy of diagnosis and the reduction of side effects in cancer treatments. Dysregulated H 2 S production from the enzyme system of overexpressed cystathionine β-synthase has long been considered to act as an autocrine and paracrine factor for the tumor growth and proliferation of colon cancer. Herein, for the first time, an endogenous H 2 S-activated copper metal–organic framework (Cu-MOF; HKUST-1) nanoenzyme has been demonstrated to synergistically mediate H 2 S-activated near-infrared photothermal therapy and chemodynamic therapy in the effective treatment of colon cancer. This endogenous biomarker-triggered “turn-on” strategy to generate therapeutic agents in situ could largely simplify the constitution of nanomedicine by avoiding the cargo introduction and thus supply great promise for the precise treatments of colon cancer.

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Crossref · 10.1021/acsami.0c08659

Cites

71 of 71 references verified0 citation errors · 0 not checkable

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  • An endogenous copper metal-organic framework nanoenzyme has been demonstrated to mediate the synergistic interaction between H2S-activated NIR PTT and chemodynamic therapy in the successful treatment of colon cancer.

    “An endogenous copper metal-organic framework nanoenzyme has been demonstrated to mediate the synergistic interaction between H2S-activated NIR PTT and chemodynamic therapy in the successful treatment of colon cancer, according to a recent study.”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [126]

  • The endogenous biomarker-triggered turn-on technique to produce therapeutic molecules in situ could greatly simplify the construction of nanomedicine and hold significant promise for the targeted treatment of colon cancer.

    “By avoiding the introduction of cargo, this endogenous biomarker-triggered “turn-on” technique to produce therapeutic molecules in situ could greatly simplify the construction of nanomedicine and hold significant promise for the targeted treatment of colon cancer.126”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [126]

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Authors
Li, Y., Zhou, J., Wang, L., & Xie, Z.
Affiliations
  • University of Science and Technology of China (CN)
  • Chinese Academy of Sciences (CN)
Corresponding author
  • Wang, Lei
  • Xie, Zhigang
Venue
ACS Applied Materials & Interfaces
Published
2020-06-09
Volume
12
Issue
27
Pages
30213-30220
ISSN
  • 1944-8244 (ISSN-L)
  • 1944-8252
OpenAlex
W3033193196
Cited by
125
References
71
Citations by year
2026: 8 · 2025: 17 · 2024: 18 · 2023: 30 · 2022: 22 · 2021: 24 · 2020: 5
FWCI
6.36
Type
journal article
Language
en
Open access
closed
Locations
  • ACS Applied Materials & Interfaces (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (21771174 and 51522307)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Materials Science › Materials Chemistry › Advanced Nanomaterials in Catalysis
  • Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Organic Frameworks: Synthesis and Applications
Keywords
hydrogen sulfide, copper metal-organic framework, HKUST-1, nanozymes, cystathionine beta-synthase, colon cancer, near-infrared photothermal therapy, chemodynamic therapy, tumor microenvironment
MeSH terms
Metal-Organic Frameworks, Photothermal Therapy, Humans, Hydrogen Sulfide, Cell Line, Tumor, Nanomedicine, Nanoparticles

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