Endogenous Hydrogen Sulfide-Triggered MOF-Based Nanoenzyme for Synergic Cancer Therapy
Abstract
The developing nanoparticle therapeutic agents triggered by tumor microenvironment are a feasible strategy for the substantial elevation of accuracy of diagnosis and the reduction of side effects in cancer treatments. Dysregulated H 2 S production from the enzyme system of overexpressed cystathionine β-synthase has long been considered to act as an autocrine and paracrine factor for the tumor growth and proliferation of colon cancer. Herein, for the first time, an endogenous H 2 S-activated copper metal–organic framework (Cu-MOF; HKUST-1) nanoenzyme has been demonstrated to synergistically mediate H 2 S-activated near-infrared photothermal therapy and chemodynamic therapy in the effective treatment of colon cancer. This endogenous biomarker-triggered “turn-on” strategy to generate therapeutic agents in situ could largely simplify the constitution of nanomedicine by avoiding the cargo introduction and thus supply great promise for the precise treatments of colon cancer.
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An endogenous copper metal-organic framework nanoenzyme has been demonstrated to mediate the synergistic interaction between H2S-activated NIR PTT and chemodynamic therapy in the successful treatment of colon cancer.
“An endogenous copper metal-organic framework nanoenzyme has been demonstrated to mediate the synergistic interaction between H2S-activated NIR PTT and chemodynamic therapy in the successful treatment of colon cancer, according to a recent study.”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [126]
The endogenous biomarker-triggered turn-on technique to produce therapeutic molecules in situ could greatly simplify the construction of nanomedicine and hold significant promise for the targeted treatment of colon cancer.
“By avoiding the introduction of cargo, this endogenous biomarker-triggered “turn-on” technique to produce therapeutic molecules in situ could greatly simplify the construction of nanomedicine and hold significant promise for the targeted treatment of colon cancer.126”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [126]
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- Authors
- Li, Y., Zhou, J., Wang, L., & Xie, Z.
- Affiliations
- University of Science and Technology of China (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Wang, Lei
- Xie, Zhigang
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-06-09
- Volume
- 12
- Issue
- 27
- Pages
- 30213-30220
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W3033193196
- Cited by
- 125
- References
- 71
- Citations by year
- 2026: 8 · 2025: 17 · 2024: 18 · 2023: 30 · 2022: 22 · 2021: 24 · 2020: 5
- FWCI
- 6.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Applied Materials & Interfaces (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (21771174 and 51522307)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Materials Chemistry › Advanced Nanomaterials in Catalysis
- Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Organic Frameworks: Synthesis and Applications
- Keywords
- hydrogen sulfide, copper metal-organic framework, HKUST-1, nanozymes, cystathionine beta-synthase, colon cancer, near-infrared photothermal therapy, chemodynamic therapy, tumor microenvironment
- MeSH terms
- Metal-Organic Frameworks, Photothermal Therapy, Humans, Hydrogen Sulfide, Cell Line, Tumor, Nanomedicine, Nanoparticles
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