The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
One-Step Integration of Tumor Microenvironment-Responsive Calcium and Copper Peroxides Nanocomposite for Enhanced Chemodynamic/Ion-Interference Therapy
Abstract
Recently, various metal peroxide nanomaterials have drawn increasing attention as an efficient hydrogen peroxide (H 2 O 2 ) self-supplying agent for enhanced tumor therapy. However, a single kind of metal peroxide is insufficient to achieve more effective antitumor performance. Here, a hyaluronic acid modified calcium and copper peroxides nanocomposite has been synthesized by a simple one-step strategy. After effective accumulation at the tumor site due to the enhanced permeability and retention (EPR) effect and specific recognition of hyaluronate acid with CD44 protein on the surface of tumor cells, plenty of Ca 2+, Cu 2+, and H 2 O 2 can be simultaneously released in acid and hyaluronidase overexpressed tumor microenvironment (TME), generating abundant hydroxyl radical through enhanced Fenton-type reaction between Cu 2+ and self-supplying H 2 O 2 with the assistance of glutathione depletion. Overloaded Ca 2+ can lead to mitochondria injury and thus enhance the oxidative stress in tumor cells. Moreover, an unbalanced calcium transport channel caused by oxidative stress can further promote tumor calcification and necrosis, which is generally defined as ion-interference therapy. As a result, the synergistic effect of Fenton-like reaction by Cu 2+ and mitochondria dysfunction by Ca 2+ in ROS generation is performed. Therefore, a TME-responsive calcium and copper peroxides nanocomposite based on one-step integration has been successfully established and exhibits a more satisfactory antitumor efficiency than any single kind of metal peroxide.
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Cites
Chemodynamic Therapy: Tumour Microenvironment‐Mediated Fenton and Fenton‐like Reactions
Tang, Z., Liu, Y., He, M., & Bu, W. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201805664 · Cited by 1,951
Tumor-selective catalytic nanomedicine by nanocatalyst delivery
Huo, M., Wang, L., Chen, Y., & Shi, J. (2017) · Nature Communications · doi:10.1038/s41467-017-00424-8 · Cited by 1,322
Synthesis of Copper Peroxide Nanodots for H2O2 Self-Supplying Chemodynamic Therapy
Lin, L.-S., Huang, T., Song, J., Ou, X.-Y., Wang, Z., Deng, H., Tian, R., Liu, Y., Wang, J.-F., Liu, Y., et al. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b03457 · Cited by 1,129
Biomedicine Meets Fenton Chemistry
Tang, Z., Zhao, P., Wang, H., Liu, Y., & Bu, W. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00977 · Cited by 745
Nanocatalytic Tumor Therapy by Biomimetic Dual Inorganic Nanozyme‐Catalyzed Cascade Reaction
Gao, S., Lin, H., Zhang, H., Yao, H., Chen, Y., & Shi, J. (2019) · Advanced Science · doi:10.1002/advs.201801733 · Cited by 645
Lu, K., He, C., Guo, N., Chan, C., Ni, K., Lan, G., Tang, H., Pelizzari, C., Fu, Y.-X., Spiotto, M. T., et al. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0203-4 · Cited by 596
Nanoenzyme-Augmented Cancer Sonodynamic Therapy by Catalytic Tumor Oxygenation
Zhu, P., Chen, Y., & Shi, J. (2018) · ACS Nano · doi:10.1021/acsnano.8b00999 · Cited by 572
Calcium-Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles
Zhang, M., Song, R., Liu, Y., Yi, Z., Meng, X., Zhang, J., Tang, Z., Yao, Z., Liu, Y., Liu, X., et al. (2019) · Chem · doi:10.1016/j.chempr.2019.06.003 · Cited by 527
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Cited by
Yang, Y., Wang, J., Huang, S., Li, M., Chen, J., Pei, D., Tang, Z., & Guo, B. (2024) · National Science Review · doi:10.1093/nsr/nwae044 · Cited by 266
Metadata
- Authors
- Liu, B., Bian, Y., Liang, S., Yuan, M., Dong, S., He, F., Gai, S., Yang, P., Cheng, Z., & Lin, J.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2021-12-27
- Volume
- 16
- Issue
- 1
- Pages
- 617-630
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W4200586202
- Cited by
- 257
- References
- 65
- FWCI
- 11.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liu, B., Bian, Y., Liang, S., Yuan, M., Dong, S., He, F., Gai, S., Yang, P., Cheng, Z., & Lin, J. (2022). One-Step Integration of Tumor Microenvironment-Responsive Calcium and Copper Peroxides Nanocomposite for Enhanced Chemodynamic/Ion-Interference Therapy. ACS Nano. https://doi.org/10.1021/acsnano.1c07893
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