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A Multi‐action and Multi‐target RuII–PtIV Conjugate Combining Cancer‐Activated Chemotherapy and Photodynamic Therapy to Overcome Drug Resistant Cancers
Open accessAbstract
Pt II complexes are commonly used to treat cancer. To reduce their side effects and improve their pharmacological properties, Pt IV complexes are being developed as prodrug candidates that are activated by reduction in cancer cells. Concomitantly, Ru II polypyridine complexes have gained much attention as photosensitizers for use in photodynamic therapy due to their attractive characteristics. In this article, a novel Pt IV–Ru II conjugate, which combines cancer activated chemotherapy with PDT, is presented. Upon entering the cancer cell, the Pt IV centre is reduced to Pt II and the axial ligands including the Ru II complex and phenylbutyrate are released. As each component has its individual targets, the conjugate exerts a multi‐target and multi‐action effect with (photo‐)cytotoxicity values upon irradiation up to 595 nm in the low nanomolar range in various (drug resistant) 2D monolayer cancer cells and 3D multicellular tumour spheroids.
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Florea, A.-M., & Büsselberg, D. (2011) · Cancers · doi:10.3390/cancers3011351 · Cited by 1,759
Spheroid-based drug screen: Considerations and practical approach
Friedrich, J., Seidel, C., Ebner, R., & Kunz-Schughart, L. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.226 · Cited by 1,742
Cited by
Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813
Lee, L. C.-C., & Lo, K. K.-W. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c03437 · Cited by 279
Metallodrugs in cancer nanomedicine
Peña, Q., Wang, A., Zaremba, O., Shi, Y., Scheeren, H. W., Metselaar, J. M., Kiessling, F., Pallares, R. M., Wuttke, S., & Lammers, T. (2022) · Chemical Society Reviews · doi:10.1039/d1cs00468a · Cited by 259
Shen, J., Karges, J., Xiong, K., Chen, Y., Ji, L., & Chao, H. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120979 · Cited by 130
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Metadata
- Authors
- Karges, J., Yempala, T., Tharaud, M., Gibson, D., & Gasser, G.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2020-03-11
- Volume
- 59
- Issue
- 18
- Pages
- 7069-7075
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W3004888761
- Cited by
- 232
- References
- 2
- FWCI
- 13.23
- Type
- journal article
- Language
- en
- Open access
- green
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- Karges, J., Yempala, T., Tharaud, M., Gibson, D., & Gasser, G. (2020). A Multi‐action and Multi‐target RuII–PtIV Conjugate Combining Cancer‐Activated Chemotherapy and Photodynamic Therapy to Overcome Drug Resistant Cancers. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201916400
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