The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
A General Strategy to Control Viscosity Sensitivity of Molecular Rotor‐Based Fluorophores
Open accessAbstract
Molecular rotor‐based fluorophores (RBFs) have been widely used in many fields. However, the lack of control of their viscosity sensitivity limits their application. Herein, this problem is resolved by chemically installing extended π‐rich alternating carbon‐carbon linkages between the rotational electron donors and acceptors of RBFs. The data reveal that the length of the linkage strongly influences the viscosity sensitivity, likely resulting from varying height of the energy barriers between the fluorescent planar and the dark twisted configurations. Three RBF derivatives that span a wide range of viscosity sensitivities were designed. These RBFs demonstrated, through a dual‐color imaging strategy, that they can differentiate misfolded protein oligomers and insoluble aggregates, both in test tubes and live cells. Beyond RBFs, it is envisioned that this chemical mechanism might be generally applicable to a wide range of photoisomerizable and aggregation‐induced emission fluorophores.
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Aggregation-Induced Emission: Together We Shine, United We Soar!
Mei, J., Leung, N. L. C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00263 · Cited by 8,270
Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062
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Aggresomes: A Cellular Response to Misfolded Proteins
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Specific light-up bioprobes based on AIEgen conjugates
Liang, J., Tang, B. Z., & Liu, B. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00444b · Cited by 762
Firefly luciferase mutants as sensors of proteome stress
Gupta, R., Kasturi, P., Bracher, A., Loew, C., Zheng, M., Villella, A., Garza, D., Hartl, F. U., & Raychaudhuri, S. (2011) · Nature Methods · doi:10.1038/nmeth.1697 · Cited by 219
Cited by
Wang, C., Chi, W., Qiao, Q., Tan, D., Xu, Z., & Liu, X. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00239b · Cited by 710
Metadata
- Authors
- Ye, S., Zhang, H., Fei, J., Wolstenholme, C. H., & Zhang, X.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2020-11-16
- Volume
- 60
- Issue
- 3
- Pages
- 1339-1346
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W3091138450
- Cited by
- 207
- References
- 9
- FWCI
- 10.72
- Type
- journal article
- Language
- en
- Open access
- green
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